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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Research

Accumulation of Fascin+ cells during experimental autoimmune neuritis

Authors: Zichen Yang, Jian Sun, Xiaofeng Yang, Zhiyuan Zhang, Bangwei Lou, Jian Xiong, Hermann J Schluesener, Zhiren Zhang

Published in: Diagnostic Pathology | Issue 1/2013

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Abstract

Background

Experimental autoimmune neuritis (EAN) is a well-known animal model of human demyelinating polyneuropathies and is characterized by inflammation and demyelination in the peripheral nervous system. Fascin is an evolutionarily highly conserved cytoskeletal protein of 55 kDa containing two actin binding domains that cross-link filamentous actin to hexagonal bundles.

Methods

Here we have studied by immunohistochemistry the spatiotemporal accumulation of Fascin + cells in sciatic nerves of EAN rats.

Results

A robust accumulation of Fascin + cell was observed in the peripheral nervous system of EAN which was correlated with the severity of neurological signs in EAN.

Conclusion

Our results suggest a pathological role of Fascin in EAN.

Virtual slides

The virtual slides for this article can be found here: http://​www.​diagnosticphatol​ogy.​diagnomx.​eu/​vs/​6734593451114811​
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Metadata
Title
Accumulation of Fascin+ cells during experimental autoimmune neuritis
Authors
Zichen Yang
Jian Sun
Xiaofeng Yang
Zhiyuan Zhang
Bangwei Lou
Jian Xiong
Hermann J Schluesener
Zhiren Zhang
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-213

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