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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Case Report

Case report: Papillary mesothelioma of the peritoneum with foamy cell lining

Authors: Simona Stolnicu, Enoe Quiñonez, Monica Boros, Claudiu Molnar, Isabel Dulcey, Francisco F Nogales

Published in: Diagnostic Pathology | Issue 1/2013

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Abstract

A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membrane staining for thrombomodulin, podoplanin D2-40 and HBME-1. In contrast, lining cells were CD68 negative. Foamy cell change has been reported in isolated cases as solid cords but not as a diffuse change in the mesothelial papillary lining. This phenomenon prompts differential diagnoses with abdominal and renal papillary clear cell tumours, which were discarded after a characteristic mesothelial immunophenotype was demonstrated.

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Literature
1.
Baker PM, Clement PB, Young RH: Malignant peritoneal mesothelioma in women: a study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. Am J Clin Pathol. 2005, 123: 724-737. 10.1309/2H0NVRERPP2LJDUA.CrossRefPubMed
2.
Kannerstein M, Churg J: Peritoneal mesothelioma. Hum Pathol. 1977, 8: 83-94. 10.1016/S0046-8177(77)80067-1.CrossRefPubMed
3.
Kerrigan SA, Turnnir RT, Clement PB, Young RH, Churg A: Diffuse malignant epithelial mesotheliomas of the peritoneum in women: a clinicopathologic study of 25 patients. Cancer. 2002, 94: 378-385. 10.1002/cncr.10209.CrossRefPubMed
4.
Goldblum J, Hart WR: Localized and diffuse mesotheliomas of the genital tract and peritoneum in women. A clinicopathologic study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas, and localized fibrous tumors. Am J Surg Pathol. 1995, 19: 1124-1137. 10.1097/00000478-199510000-00003.CrossRefPubMed
5.
Kitazawa M, Kaneko H, Toshima M, Ishikawa H, Kobayashi H, Sekiya M: Malignant peritoneal mesothelioma with massive foamy cells. Codfish roe-like mesothelioma. Acta Pathol Jpn. 1984, 34: 687-692.PubMed
6.
Mikuz G, Hopfel-Kreiner I: Papillary mesothelioma of the tunica vaginalis propria testis. Case report and Ultrastructural study virchows arch. A Pathol Anat Histol. 1982, 396: 231-238. 10.1007/BF00431244.CrossRef
7.
Cavazza A, Pasquinelli G, Agostini L, Leslie KO, Colby TV: Foamy cell mesothelioma. Histopathology. 2002, 41: 369-371. 10.1046/j.1365-2559.2002.14044.x.CrossRefPubMed
8.
Ordonez NG: The use of immunohistochemistry in the diagnosis of composite and collision tumors: exemplified by pleural mesothelioma and carcinoid tumor of the lung. Appl Immunohistochem Mol Morphol. 2012, 20: 421-426. 10.1097/PAI.0b013e318238bb8f.CrossRefPubMed
9.
Komorowski RA, Bobert DH: Peritoneal mesothelioma presenting as an adnexal mass. South Med J. 1975, 68: 83-85. 10.1097/00007611-197501000-00022.CrossRefPubMed
10.
Davis DL: Secret history of the War on cancer. 2007, New York: Basic Books, 258-260.
11.
Bitchatchi E, Kayser K, Perelman M, Richter ED: Mesothelioma and asbestosis in a young woman following occupational asbestos exposure: Short latency and long survival: Case Report. Diagn Pathol. 2010, 5: 81-10.1186/1746-1596-5-81.PubMedCentralCrossRefPubMed
12.
Jaugitz H: Comparing electron microscopical investigation of cells from mesotheliomas (author’s transl). Arch Geschwulstforsch. 1977, 47: 204-209.PubMed
13.
Adsay V, Logani S, Sarkar F, Crissman J, Vaitkevicius V: Foamy gland pattern of pancreatic ductal adenocarcinoma: a deceptively benign-appearing variant. Am J Surg Pathol. 2000, 24: 493-504. 10.1097/00000478-200004000-00003.CrossRefPubMed
14.
Kayser K, Bohm G, Blum S, Beyer M, Zink S, Andre S, Gabius HJ: Glyco- and immunohistochemical refinement of the differential diagnosis between mesothelioma and metastatic carcinoma and survival analysis of patients. J Pathol. 2001, 193: 175-180. 10.1002/1096-9896(2000)9999:9999<::AID-PATH772>3.0.CO;2-T.CrossRefPubMed
15.
Rohan SM, Xiao Y, Liang Y, Dudas ME, Al-Ahmadie HA, Fine SW, Gopalan A, Reuter VE, Rosenblum MK, Russo P, Tickoo SK: Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von hippel-lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol. 2011, 24: 1207-1220. 10.1038/modpathol.2011.80.CrossRefPubMed
16.
Nelson RS, Epstein JI: Prostatic carcinoma with abundant xanthomatous cytoplasm. Foamy gland carcinoma. Am J Surg Pathol. 1996, 20: 419-426. 10.1097/00000478-199604000-00004.CrossRefPubMed
17.
Tran TT, Sengupta E, Yang XJ: Prostatic foamy gland carcinoma with aggressive behavior: clinicopathologic, immunohistochemical, and ultrastructural analysis. Am J Surg Pathol. 2001, 25: 618-623. 10.1097/00000478-200105000-00008.CrossRefPubMed
18.
Sandeck HP, Roe OD, Kjaerheim K, Willen H, Larsson E: Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry. Diagn Pathol. 2010, 5: 47-10.1186/1746-1596-5-47.PubMedCentralCrossRefPubMed
Metadata
Title
Case report: Papillary mesothelioma of the peritoneum with foamy cell lining
Authors
Simona Stolnicu
Enoe Quiñonez
Monica Boros
Claudiu Molnar
Isabel Dulcey
Francisco F Nogales
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-162

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