Skip to main content
Top
Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Case Report

Retroperitoneal composite pheochromocytoma-ganglioneuroma: a case report and review of literature

Authors: Jinchen Hu, Jitao Wu, Li Cai, Lei Jiang, Zhiqiang Lang, Guimei Qu, Houcai Liu, Weidong Yao, Guohua Yu

Published in: Diagnostic Pathology | Issue 1/2013

Login to get access

Abstract

Composite pheochromocytoma/paraganglioma is a rare tumor with elements of pheochromocytoma/paraganglioma and neurogenic tumor. Most were located in the adrenal glands, and extra-adrenal composite pheochromocytoma is extremely rare. Only 4 cases in the retroperitoneum have been described in the online database PUBMED. Here, we report a case of retroperitoneal extra-adrenal composite pheochromocytoma and review the related literature.

Virtual slides

Appendix
Available only for authorised users
Literature
1.
go back to reference Disick GI, Palese MA: Extra-adrenal pheochromocytoma: diagnosis and management. Curr Urol Rep. 2007, 8: 83-88. 10.1007/s11934-007-0025-5.CrossRefPubMed Disick GI, Palese MA: Extra-adrenal pheochromocytoma: diagnosis and management. Curr Urol Rep. 2007, 8: 83-88. 10.1007/s11934-007-0025-5.CrossRefPubMed
2.
go back to reference Chen CH, Boag AH, Beiko DT, Siemens DR, Froese A, Isotalo PA: Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection. Can Urol Assoc J. 2009, 3: E45-E48.PubMedCentralPubMed Chen CH, Boag AH, Beiko DT, Siemens DR, Froese A, Isotalo PA: Composite paraganglioma-ganglioneuroma of the urinary bladder: a rare neoplasm causing hemodynamic crisis at tumour resection. Can Urol Assoc J. 2009, 3: E45-E48.PubMedCentralPubMed
3.
go back to reference Gong J, Wang X, Chen X, Chen N, Huang R, Lu C, Chen D, Zeng H, Zhou Q: Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases. Urol Int. 2010, 85: 368-372. 10.1159/000317312.CrossRefPubMed Gong J, Wang X, Chen X, Chen N, Huang R, Lu C, Chen D, Zeng H, Zhou Q: Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases. Urol Int. 2010, 85: 368-372. 10.1159/000317312.CrossRefPubMed
4.
go back to reference Hirasaki S, Kanzaki H, Okuda M, Suzuki S, Fukuhara T, Hanaoka T: Composite paraganglioma-ganglioneuroma in the retroperitoneum. World J Surg Oncol. 2009, 7: 81-10.1186/1477-7819-7-81.PubMedCentralCrossRefPubMed Hirasaki S, Kanzaki H, Okuda M, Suzuki S, Fukuhara T, Hanaoka T: Composite paraganglioma-ganglioneuroma in the retroperitoneum. World J Surg Oncol. 2009, 7: 81-10.1186/1477-7819-7-81.PubMedCentralCrossRefPubMed
5.
go back to reference Pytel P, Krausz T, Wollmann R, Utset MF: Ganglioneuromatous paraganglioma of the cauda equina–a pathological case study. Hum Pathol. 2005, 36: 444-446. 10.1016/j.humpath.2005.01.024.CrossRefPubMed Pytel P, Krausz T, Wollmann R, Utset MF: Ganglioneuromatous paraganglioma of the cauda equina–a pathological case study. Hum Pathol. 2005, 36: 444-446. 10.1016/j.humpath.2005.01.024.CrossRefPubMed
6.
go back to reference Tohme CA, Mattar WE, Ghorra CS: Extra-adrenal composite pheochromocytoma-ganglioneuroma. Saudi Med J. 2006, 27: 1594-1597.PubMed Tohme CA, Mattar WE, Ghorra CS: Extra-adrenal composite pheochromocytoma-ganglioneuroma. Saudi Med J. 2006, 27: 1594-1597.PubMed
7.
go back to reference Yoshimi N, Tanaka T, Hara A, Bunai Y, Kato K, Mori H: Extra-adrenal pheochromocytoma-ganglioneuroma. A case report. Pathol Res Pract. 1992, 188: 1098-1100. 10.1016/S0344-0338(11)81261-6. discussion 1101–1103CrossRefPubMed Yoshimi N, Tanaka T, Hara A, Bunai Y, Kato K, Mori H: Extra-adrenal pheochromocytoma-ganglioneuroma. A case report. Pathol Res Pract. 1992, 188: 1098-1100. 10.1016/S0344-0338(11)81261-6. discussion 1101–1103CrossRefPubMed
8.
go back to reference Linnoila RI, Keiser HR, Steinberg SM, Lack EE: Histopathology of benign versus malignant sympathoadrenal paragangliomas: clinicopathologic study of 120 cases including unusual histologic features. Hum Pathol. 1990, 21: 1168-1180. 10.1016/0046-8177(90)90155-X.CrossRefPubMed Linnoila RI, Keiser HR, Steinberg SM, Lack EE: Histopathology of benign versus malignant sympathoadrenal paragangliomas: clinicopathologic study of 120 cases including unusual histologic features. Hum Pathol. 1990, 21: 1168-1180. 10.1016/0046-8177(90)90155-X.CrossRefPubMed
9.
go back to reference Khan AN, Solomon SS, Childress RD: Composite pheochromocytoma-ganglioneuroma: a rare experiment of nature. Endocr Pract. 2010, 16: 291-299. 10.4158/EP09205.RA.CrossRefPubMed Khan AN, Solomon SS, Childress RD: Composite pheochromocytoma-ganglioneuroma: a rare experiment of nature. Endocr Pract. 2010, 16: 291-299. 10.4158/EP09205.RA.CrossRefPubMed
10.
go back to reference Shahani S, Nudelman RJ, Nalini R, Kim HS, Samson SL: Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature. Diagn Pathol. 2010, 5: 56-10.1186/1746-1596-5-56.PubMedCentralCrossRefPubMed Shahani S, Nudelman RJ, Nalini R, Kim HS, Samson SL: Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature. Diagn Pathol. 2010, 5: 56-10.1186/1746-1596-5-56.PubMedCentralCrossRefPubMed
11.
go back to reference Mahajan H, Lee D, Sharma R, Chin P, Watt WH, McBride G, Bilous M: Composite phaeochromocytoma-ganglioneuroma, an uncommon entity: report of two cases. Pathology. 2010, 42: 295-298. 10.3109/00313021003636451.CrossRefPubMed Mahajan H, Lee D, Sharma R, Chin P, Watt WH, McBride G, Bilous M: Composite phaeochromocytoma-ganglioneuroma, an uncommon entity: report of two cases. Pathology. 2010, 42: 295-298. 10.3109/00313021003636451.CrossRefPubMed
12.
go back to reference Kimura N, Watanabe T, Fukase M, Wakita A, Noshiro T, Kimura I: Neurofibromin and NF1 gene analysis in composite pheochromocytoma and tumors associated with von Recklinghausen’s disease. Mod Pathol. 2002, 15: 183-188. 10.1038/modpathol.3880513.CrossRefPubMed Kimura N, Watanabe T, Fukase M, Wakita A, Noshiro T, Kimura I: Neurofibromin and NF1 gene analysis in composite pheochromocytoma and tumors associated with von Recklinghausen’s disease. Mod Pathol. 2002, 15: 183-188. 10.1038/modpathol.3880513.CrossRefPubMed
13.
go back to reference Gullu S, Gursoy A, Erdogan MF, Dizbaysak S, Erdogan G, Kamel N: Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuroma. J Endocrinol Invest. 2005, 28: 734-737.CrossRefPubMed Gullu S, Gursoy A, Erdogan MF, Dizbaysak S, Erdogan G, Kamel N: Multiple endocrine neoplasia type 2A/localized cutaneous lichen amyloidosis associated with malignant pheochromocytoma and ganglioneuroma. J Endocrinol Invest. 2005, 28: 734-737.CrossRefPubMed
14.
go back to reference Tischler AS: Divergent differentiation in neuroendocrine tumors of the adrenal gland. Semin Diagn Pathol. 2000, 17: 120-126.PubMed Tischler AS: Divergent differentiation in neuroendocrine tumors of the adrenal gland. Semin Diagn Pathol. 2000, 17: 120-126.PubMed
15.
go back to reference Sun YH, Wen W, Wu JH, Song JM, Guan H, Wang KX, Xu MQ: Endolymphatic sac tumor: case report and review of the literature. Diagn Pathol. 2012, 7: 36-10.1186/1746-1596-7-36.PubMedCentralCrossRefPubMed Sun YH, Wen W, Wu JH, Song JM, Guan H, Wang KX, Xu MQ: Endolymphatic sac tumor: case report and review of the literature. Diagn Pathol. 2012, 7: 36-10.1186/1746-1596-7-36.PubMedCentralCrossRefPubMed
16.
go back to reference Lam KY, Lo CY: Composite pheochromocytoma-ganglioneuroma of the adrenal gland: an uncommon entity with distinctive clinicopathologic features. Endocr Pathol. 1999, 10: 343-352. 10.1007/BF02739777.CrossRefPubMed Lam KY, Lo CY: Composite pheochromocytoma-ganglioneuroma of the adrenal gland: an uncommon entity with distinctive clinicopathologic features. Endocr Pathol. 1999, 10: 343-352. 10.1007/BF02739777.CrossRefPubMed
17.
go back to reference Comstock JM, Willmore-Payne C, Holden JA, Coffin CM: Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Am J Clin Pathol. 2009, 132: 69-73. 10.1309/AJCPN76VTIGWPOAG.CrossRefPubMed Comstock JM, Willmore-Payne C, Holden JA, Coffin CM: Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Am J Clin Pathol. 2009, 132: 69-73. 10.1309/AJCPN76VTIGWPOAG.CrossRefPubMed
Metadata
Title
Retroperitoneal composite pheochromocytoma-ganglioneuroma: a case report and review of literature
Authors
Jinchen Hu
Jitao Wu
Li Cai
Lei Jiang
Zhiqiang Lang
Guimei Qu
Houcai Liu
Weidong Yao
Guohua Yu
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-63

Other articles of this Issue 1/2013

Diagnostic Pathology 1/2013 Go to the issue