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Cough
Published in: Cough 1/2013

Open Access 01-12-2013 | Review

Molecular signaling and targets from itch: lessons for cough

Authors: Pamela Colleen LaVinka, Xingzhong Dong

Published in: Cough | Issue 1/2013

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Abstract

Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.
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Metadata
Title
Molecular signaling and targets from itch: lessons for cough
Authors
Pamela Colleen LaVinka
Xingzhong Dong
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Cough / Issue 1/2013
Electronic ISSN: 1745-9974
DOI
https://doi.org/10.1186/1745-9974-9-8

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