Skip to main content
Top
Published in: Trials 1/2013

Open Access 01-12-2013 | Commentary

Trial-based clinical and economic analyses: the unhelpful quest for conformity

Authors: David GT Whitehurst, Stirling Bryan

Published in: Trials | Issue 1/2013

Login to get access

Abstract

Where there is conformity across the findings, interpretation and implications of 'clinical’ and 'economic’ research, there is limited cause for concern. However, there is often unease when apparent contradictory conclusions are drawn from the same study. Given the ever increasing role for economic evaluation in healthcare decision making, this commentary challenges the necessity of compatibility between clinical and economic evaluation.
Literature
1.
go back to reference Pharmaceutical Benefits Scheme (PBS): Guidelines for Preparing Submissions to the Pharmaceutical Benefits Advisory Committee (PBAC) (Version 4.3). 2008, Canberra, Australia: Pharmaceutical Benefits Scheme Pharmaceutical Benefits Scheme (PBS): Guidelines for Preparing Submissions to the Pharmaceutical Benefits Advisory Committee (PBAC) (Version 4.3). 2008, Canberra, Australia: Pharmaceutical Benefits Scheme
2.
go back to reference National Institute for Health and Care Excellence: Guide to the Methods of Technology Appraisal 2013. 2013, London, UK: National Institute for Health and Care Excellence National Institute for Health and Care Excellence: Guide to the Methods of Technology Appraisal 2013. 2013, London, UK: National Institute for Health and Care Excellence
4.
go back to reference MacPherson H, Tilbrook H, Bland JM, Bloor K, Brabyn S, Cox H, Kang’ombe AR, Man MS, Stuardi T, Torgerson D, Watt I, Whorwell P: Acupuncture for irritable bowel syndrome: primary care based pragmatic randomised controlled trial. BMC Gastroenterol. 2012, 12: 150-10.1186/1471-230X-12-150.CrossRefPubMedPubMedCentral MacPherson H, Tilbrook H, Bland JM, Bloor K, Brabyn S, Cox H, Kang’ombe AR, Man MS, Stuardi T, Torgerson D, Watt I, Whorwell P: Acupuncture for irritable bowel syndrome: primary care based pragmatic randomised controlled trial. BMC Gastroenterol. 2012, 12: 150-10.1186/1471-230X-12-150.CrossRefPubMedPubMedCentral
5.
go back to reference Stamuli E, Bloor K, MacPherson H, Tilbrook H, Stuardi T, Brabyn S, Torgerson D: Cost-effectiveness of acupuncture for irritable bowel syndrome: findings from an economic evaluation conducted alongside a pragmatic randomised controlled trial in primary care. BMC Gastroenterol. 2012, 12: 149-10.1186/1471-230X-12-149.CrossRefPubMedPubMedCentral Stamuli E, Bloor K, MacPherson H, Tilbrook H, Stuardi T, Brabyn S, Torgerson D: Cost-effectiveness of acupuncture for irritable bowel syndrome: findings from an economic evaluation conducted alongside a pragmatic randomised controlled trial in primary care. BMC Gastroenterol. 2012, 12: 149-10.1186/1471-230X-12-149.CrossRefPubMedPubMedCentral
6.
go back to reference Whitehurst DG, Lewis M, Yao GL, Bryan S, Raftery JP, Mullis R, Hay EM: A brief pain management program compared with physical therapy for low back pain: results from an economic analysis alongside a randomized clinical trial. Arthritis Rheum. 2007, 57: 466-473. 10.1002/art.22606.CrossRefPubMed Whitehurst DG, Lewis M, Yao GL, Bryan S, Raftery JP, Mullis R, Hay EM: A brief pain management program compared with physical therapy for low back pain: results from an economic analysis alongside a randomized clinical trial. Arthritis Rheum. 2007, 57: 466-473. 10.1002/art.22606.CrossRefPubMed
7.
go back to reference van Wier MF, Lakerveld J, Bot SD, Chinapaw MJ, Nijpels G, van Tulder MW: Economic evaluation of a lifestyle intervention in primary care to prevent type 2 diabetes mellitus and cardiovascular diseases: a randomized controlled trial. BMC Fam Pract. 2013, 14: 45-10.1186/1471-2296-14-45.CrossRefPubMedPubMedCentral van Wier MF, Lakerveld J, Bot SD, Chinapaw MJ, Nijpels G, van Tulder MW: Economic evaluation of a lifestyle intervention in primary care to prevent type 2 diabetes mellitus and cardiovascular diseases: a randomized controlled trial. BMC Fam Pract. 2013, 14: 45-10.1186/1471-2296-14-45.CrossRefPubMedPubMedCentral
8.
go back to reference Kuhn TS: The Structure of Scientific Revolutions. 1970, Chicago: University of Chicago Press, 2 Kuhn TS: The Structure of Scientific Revolutions. 1970, Chicago: University of Chicago Press, 2
9.
go back to reference Petrou S, Gray A: Economic evaluation alongside randomised controlled trials: design, conduct, analysis, and reporting. BMJ. 2011, 342: d1548-10.1136/bmj.d1548.CrossRefPubMedPubMedCentral Petrou S, Gray A: Economic evaluation alongside randomised controlled trials: design, conduct, analysis, and reporting. BMJ. 2011, 342: d1548-10.1136/bmj.d1548.CrossRefPubMedPubMedCentral
10.
go back to reference Claxton K: The irrelevance of inference: a decision-making approach to the stochastic evaluation of health care technologies. J Health Econ. 1999, 18: 341-364. 10.1016/S0167-6296(98)00039-3.CrossRefPubMed Claxton K: The irrelevance of inference: a decision-making approach to the stochastic evaluation of health care technologies. J Health Econ. 1999, 18: 341-364. 10.1016/S0167-6296(98)00039-3.CrossRefPubMed
11.
go back to reference Briggs AH, O’Brien BJ: The death of cost-minimization analysis?. Health Econ. 2001, 10: 179-184. 10.1002/hec.584.CrossRefPubMed Briggs AH, O’Brien BJ: The death of cost-minimization analysis?. Health Econ. 2001, 10: 179-184. 10.1002/hec.584.CrossRefPubMed
13.
go back to reference Gebski V, Marschner I, Keech AC: Specifying objectives and outcomes for clinical trials. Med J Aust. 2002, 176: 491-492.PubMed Gebski V, Marschner I, Keech AC: Specifying objectives and outcomes for clinical trials. Med J Aust. 2002, 176: 491-492.PubMed
14.
go back to reference Bosmans JE, de Bruijne MC, van Hout HP, Hermens ML, Adèr HJ, van Tulder MW: Practical guidelines for economic evaluations alongside equivalence trials. Value Health. 2008, 11: 251-258. 10.1111/j.1524-4733.2007.00245.x.CrossRefPubMed Bosmans JE, de Bruijne MC, van Hout HP, Hermens ML, Adèr HJ, van Tulder MW: Practical guidelines for economic evaluations alongside equivalence trials. Value Health. 2008, 11: 251-258. 10.1111/j.1524-4733.2007.00245.x.CrossRefPubMed
15.
go back to reference Lee BB, King MT, Simpson JM, Haran MJ, Stockler MR, Marial O, Salkeld G: Validity, responsiveness, and minimal important difference for the SF-6D health utility scale in a spinal cord injured population. Value Health. 2008, 11: 680-688. 10.1111/j.1524-4733.2007.00311.x.CrossRefPubMed Lee BB, King MT, Simpson JM, Haran MJ, Stockler MR, Marial O, Salkeld G: Validity, responsiveness, and minimal important difference for the SF-6D health utility scale in a spinal cord injured population. Value Health. 2008, 11: 680-688. 10.1111/j.1524-4733.2007.00311.x.CrossRefPubMed
16.
go back to reference Luo N, Johnson J, Coons SJ: Using instrument-defined health state transitions to estimate minimally important differences for four preference-based health-related quality of life instruments. Med Care. 2010, 48: 365-371. 10.1097/MLR.0b013e3181c162a2.CrossRefPubMed Luo N, Johnson J, Coons SJ: Using instrument-defined health state transitions to estimate minimally important differences for four preference-based health-related quality of life instruments. Med Care. 2010, 48: 365-371. 10.1097/MLR.0b013e3181c162a2.CrossRefPubMed
17.
go back to reference Jaeschke R, Singer J, Guyatt GH: Measurement of health status. Ascertaining the minimal clinically important difference. Control Clin Trials. 1989, 10: 407-415. 10.1016/0197-2456(89)90005-6.CrossRefPubMed Jaeschke R, Singer J, Guyatt GH: Measurement of health status. Ascertaining the minimal clinically important difference. Control Clin Trials. 1989, 10: 407-415. 10.1016/0197-2456(89)90005-6.CrossRefPubMed
Metadata
Title
Trial-based clinical and economic analyses: the unhelpful quest for conformity
Authors
David GT Whitehurst
Stirling Bryan
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Trials / Issue 1/2013
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-14-421

Other articles of this Issue 1/2013

Trials 1/2013 Go to the issue