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Open Access 01-12-2013 | Commentary

Commentary: Why we should report results from clinical trial pilot studies

Author: Lawrence Friedman

Published in: Trials | Issue 1/2013

Excerpt

Should clinical trial pilot studies be reported? Thebane, Ma, Chu, et al. argue in their discussion of the conduct of pilot studies, that they should be published [1]. Others, such as the editorialist for The Diabetes Educator, take a more cautious approach to publishing pilot studies [2]. I agree with those who advocate publication. I might also note that a September 27, 2012 search of “randomized clinical trial pilot studies” in PubMed contained over 10,400 citations. Although some of these may not reflect individual pilot studies, there may, though, be many more (without “randomized” in the search term, the number is over 22,000). …

Thabane L, Ma J, Chu R: Commentary. A tutorial on pilot studies: the what, why and how. BMC Medial Research Methodology. 2010, 10: 1-10.1186/1471-2288-10-1.http://www.biomedcentral.com/1471-2288/10/1,CrossRef

Fain JA: Editorial. Should we publish pilot/feasibility studies?. Diabetes Educ. 2010, 36: 521-10.1177/0145721710379355.http://tde.sagepub.com/content/36/4/521,CrossRefPubMed

The Antiarrythmics Versus Implantable Defibrillators (AVID) Investigators: A comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from near fatal ventricular arrhythmias. N Engl J Med. 1997, 337: 1576-1583.CrossRef

The AVID Investigators: Antiarrhythmics Versus Implantable Defibrillators (AVID)—rationale, design, and methods. Am J Cardiol. 1995, 75: 470-475. 10.1016/S0002-9149(99)80583-9.CrossRef

Echt DS, Liebson PR, Mitchell LB: Mortality and morbidity in patients receiving encainide, flecainide, or placebo. N Engl J Med. 1991, 324: 781-788. 10.1056/NEJM199103213241201.CrossRefPubMed

The Cardiac Arrhythmia Pilot Study (CAPS) Investigators: Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS. Am J Cardiol. 1988, 61: 501-509. 10.1016/0002-9149(88)90754-0.CrossRef

Title: Commentary: Why we should report results from clinical trial pilot studies
Author: Lawrence Friedman
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Trials / Issue 1/2013
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/1745-6215-14-14

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Commentary: Why we should report results from clinical trial pilot studies

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