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Open Access 01-12-2013 | Commentary

Six pairs of things to celebrate on International Clinical Trials Day

Author: David L Sackett

Published in: Trials | Issue 1/2013

Abstract

The Editor has invited me to mark the occasion with a few words “on the development and/or impact of randomised trials over the last decade, or perhaps some thoughts about the future.” I do so here by citing some recent developments that give me cause for both pride about the present state of randomised controlled trials (RCTs) and optimism about their future. Respecting the sample size of James Lind’s trial and the space allotted me by the Editor, they appear in six pairs.

Biostatistics in Clinical Trials. Edited by: Redmond CK, Colton T. 2001, Hoboken, NJ: Wiley, 241-

Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA. 1967, 202: 116-122. 10.1001/jama.1967.03130150084015.CrossRef

Lind J: A treatise of the scurvy. In Three Parts. Containing an Inquiry into the Nature, Causes and Cure, of that Disease. Together with a Critical and Chronological View of What has been Published on the Subject. 1753, Edinburgh: A Kincaid and A Donaldson, Obtained from the James Lind Library [http://www.jameslindlibrary.org]. Accessed 9 May 2013

The James Lind Alliance: Tackling treatment uncertainties together. [http://www.lindalliance.org/] Accessed 9 May 2013

Vist GE, Bryant D, Somerville L, Birminghem T, Oxman AD: Outcomes of patients who participate in randomized controlled trials compared to similar patients receiving similar interventions who do not participate. Cochrane Database Syst Rev. 2008, 3: MR000009

Tripathy P, Nair N, Barnett S, Mahapatra R, Borghi J, Rath S, Rath S, Gope R, Mahto D, Sinha R, Lakshminarayana R, Patel V, Pagel C, Prost A, Costello A: Effect of a participatory intervention with women’s groups on birth outcomes and maternal depression in Jharkhand and Orissa, India: a cluster-randomised controlled trial. Lancet. 2010, 375: 1182-1192. 10.1016/S0140-6736(09)62042-0.CrossRefPubMed

Roberts I, Prieto-Merino D, Shakur H, Chalmers I, Nicholl J: Effect of consent rituals on mortality in emergency care research. Lancet. 2011, 377: 1071-1072. 10.1016/S0140-6736(11)60317-6.CrossRefPubMed

Christie DR, Gabriel GS, Dear K: Adverse effects of a multicentre system for ethics approval on the progress of a prospective multicentre trial of cancer treatment: how many patients die waiting?. Intern Med J. 2007, 37: 680-686.PubMed

Ontario Cancer Research Ethics Board: [http://oicr.on.ca/oicr-programs-and-platforms/ontario-cancer-research-ethics-board] Accessed 9 May 2013

10.

Sydes MR, Parmar MK, Mason MD, Clarke MW, Amos C, Anderson J, de Bono J, Dearnaley DP, Dwyer J, Green G, Jovic G, Ritchie AW, Russell J, Sanders K, Thalmann G, James ND: Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial. Trials. 2012, 13: 168-10.1186/1745-6215-13-168.CrossRefPubMedPubMedCentral

11.

Jaki T: Uptake of novel statistical methods for early-phase clinical studies in the UK public sector. Clin Trials. 2013, 10: 344-346. 10.1177/1740774512474375.CrossRefPubMed

12.

CONSORT: Transparent Reporting of Trials. [http://www.consort-statement.org/]. Accessed 9 May 2013

13.

PRISMA: Transparent Reporting of Systematic Reviews and Meta-Analyses. [http://www.prisma-statement.org/]. Accessed 9 May 2013

Title: Six pairs of things to celebrate on International Clinical Trials Day
Author: David L Sackett
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Trials / Issue 1/2013
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/1745-6215-14-128

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Six pairs of things to celebrate on International Clinical Trials Day

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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