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Molecular Pain
Published in: Molecular Pain 1/2009

Open Access 01-12-2009 | Research

Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

Authors: Xiao-Yan Cao, Hui Xu, Long-Jun Wu, Xiang-Yao Li, Tao Chen, Min Zhuo

Published in: Molecular Pain | Issue 1/2009

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Abstract

The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we characterized cingulate pyramidal cells in the layer II/III of the ACC in adult mice. We then examined possible long-term changes in intrinsic properties of the ACC pyramidal cells after peripheral nerve injury. In the control mice, we found that there are three major types of pyramidal cells according to their action potential firing pattern: (i) regular spiking (RS) cells (24.7%), intrinsic bursting (IB) cells (30.9%), and intermediate (IM) cells (44.4%). In a state of neuropathic pain, the population distribution (RS: 21.3%; IB: 31.2%; IM: 47.5%) and the single action potential properties of these three groups were indistinguishable from those in control mice. However, for repetitive action potentials, IM cells from neuropathic pain animals showed higher initial firing frequency with no change for the properties of RS and IB neurons from neuropathic pain mice. The present results provide the first evidence that, in addition to synaptic potentiation reported previously, peripheral nerve injury produces long-term plastic changes in the action potentials of cingulate pyramidal neurons in a cell type-specific manner.
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Metadata
Title
Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
Authors
Xiao-Yan Cao
Hui Xu
Long-Jun Wu
Xiang-Yao Li
Tao Chen
Min Zhuo
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2009
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/1744-8069-5-73

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