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Molecular Pain
Published in: Molecular Pain 1/2009

Open Access 01-12-2009 | Research

Excitatory neurotransmitters in brain regions in interictal migraine patients

Authors: Andrew Prescot, Lino Becerra, Gautam Pendse, Shannon Tully, Eric Jensen, Richard Hargreaves, Perry Renshaw, Rami Burstein, David Borsook

Published in: Molecular Pain | Issue 1/2009

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Abstract

Objective

To examine biochemical differences in the anterior cingulate cortex (ACC) and insula during the interictal phase of migraine patients. We hypothesized that there may be differences in levels of excitatory amino acid neurotransmitters and/or their derivatives in migraine group based on their increased sensitivity to pain.

Methods

2D J-resolved proton magnetic resonance spectroscopy (1H-MRS) data were acquired at 4.0 Tesla (T) from the ACC and insula in 10 migraine patients (7 women, 3 men, age 43 ± 11 years) and 8 age gender matched controls (7 women, 3 men, age 41 ± 9 years).

Results

Standard statistical analyses including analysis of variance (ANOVA) showed no significant metabolite differences between the two subject cohorts in the ACC nor the insula. However, linear discriminant analysis (LDA) introduced a clear separation between subject cohorts based on N-acetyl aspartylglutamate (NAAG) and glutamine (Gln) in the ACC and insula.

Conclusion

These results are consistent with glutamatergic abnormalities in the ACC and insula in migraine patients during their interictal period compared to healthy controls. An alteration in excitatory amino acid neurotransmitters and their derivatives may be a contributing factor for migraineurs for a decrease in sensitivity for migraine or a consequence of the chronic migraine state. Such findings, if extrapolated to other regions of the brain would offer new opportunities to modulate central system as interictal or preemptive medications in these patients.
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Metadata
Title
Excitatory neurotransmitters in brain regions in interictal migraine patients
Authors
Andrew Prescot
Lino Becerra
Gautam Pendse
Shannon Tully
Eric Jensen
Richard Hargreaves
Perry Renshaw
Rami Burstein
David Borsook
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2009
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/1744-8069-5-34

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