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Open Access 01-12-2014 | Oral presentation

Modeling TMJD pain in the laboratory mouse: role of TRP ion channels

Authors: Yong Chen, Fan Wang, Wolfgang Liedtke

Published in: Molecular Pain | Special Issue 1/2014

Excerpt

Trigeminal pain syndromes such as temporomandibular joint (TMJ) pain appear to have a particular potential to affect patients in a devastating manner. Prevalence of trigeminal pain disorders in the US is estimated at 20-30x10⁶, at >50-75x10⁶ including headaches/migraine. Neural circuit malfunction and maladaptive plasticity arise from altered primary sensory afferents. We have focused on a nerve cell that is the eminent gatekeeper of sensory afferent cues in the trigeminal system, trigeminal ganglion (TG) sensory neurons. These neurons, when damaged by physical, inflammatory or chemical injury, set up the ensuing maladaptive reprogramming and circuit malfunction, including pathological pain, in the CNS. …

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Title: Modeling TMJD pain in the laboratory mouse: role of TRP ion channels
Authors: Yong Chen
Fan Wang
Wolfgang Liedtke
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Molecular Pain / Issue Special Issue 1/2014
Electronic ISSN: 1744-8069
DOI: https://doi.org/10.1186/1744-8069-10-S1-O8

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Modeling TMJD pain in the laboratory mouse: role of TRP ion channels

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