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Open Access 01-12-2014 | Oral presentation

Combined genetic polymorphisms and environmental factors in the etiology of a chronic TMJD murine model

Authors: Karin N Westlund, Sabrina L McIlwrath, Helieh S Oz

Published in: Molecular Pain | Special Issue 1/2014

Excerpt

TNFR1 and TNFR2 are receptors for the pro-inflammatory chemokine TNFα. Inflammation of the temporomandibular joint (TMJ) and hypersensitivity were induced in mice lacking both TNFα receptors (TNFR1/R2 -/-). After recovery from this initial priming TMJ insult lasting less than a week, a gastrointestinal (GI) chemical irritation is administered 3 weeks later. This “double-hit” initiates a recrudescence of inflammation and hypersensitivity persisting at least 18 weeks. …

Title: Combined genetic polymorphisms and environmental factors in the etiology of a chronic TMJD murine model
Authors: Karin N Westlund
Sabrina L McIlwrath
Helieh S Oz
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Molecular Pain / Issue Special Issue 1/2014
Electronic ISSN: 1744-8069
DOI: https://doi.org/10.1186/1744-8069-10-S1-O18

At a glance: The STEP trials

Springer Medicine

Combined genetic polymorphisms and environmental factors in the etiology of a chronic TMJD murine model

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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