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Open Access 01-12-2005 | Review

Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?

Authors: Lena Koh, Andrei Zakharov, Miles Johnston

Published in: Fluids and Barriers of the CNS | Issue 1/2005

Abstract

In most tissues and organs, the lymphatic circulation is responsible for the removal of interstitial protein and fluid but the parenchyma of the brain and spinal cord is devoid of lymphatic vessels. On the other hand, the literature is filled with qualitative and quantitative evidence supporting a lymphatic function in cerebrospinal fluid (CSF) absorption. The experimental data seems to warrant a re-examination of CSF dynamics and consideration of a new conceptual foundation on which to base our understanding of disorders of the CSF system. The objective of this paper is to review the key studies pertaining to the role of the lymphatic system in CSF absorption.

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Title: Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
Authors: Lena Koh
Andrei Zakharov
Miles Johnston
Publication date: 01-12-2005
Publisher: BioMed Central
Published in: Fluids and Barriers of the CNS / Issue 1/2005
Electronic ISSN: 2045-8118
DOI: https://doi.org/10.1186/1743-8454-2-6

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Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?

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