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Nutrition & Metabolism
Published in: Nutrition & Metabolism 1/2005

Open Access 01-12-2005 | Review

Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function

Authors: Zahra Fatehi-Hassanabad, Catherine B Chan

Published in: Nutrition & Metabolism | Issue 1/2005

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Abstract

Background

Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a hypercaloric high-fat diet.

Results

Free fatty acids represent an important factor linking excess fat mass to type 2 diabetes. Several studies have shown that chronically elevated free fatty acids have a negative effect on β-cell function leading to elevated insulin secretion basally but with an impaired response to glucose. The transcription factors PPARα, PPARγ and SREBP-1c respond to changing fat concentrations in tissues, thereby coordinating the genomic response to altered metabolic conditions to promote either fat storage or catabolism. These transcription factors have been identified in β-cells and it appears that each may exert influence on β-cell function in health and disease.

Conclusion

The role of the PPARs and SREBP-1c as potential mediators of lipotoxicity is an emerging area of interest.
Appendix
Available only for authorised users
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Metadata
Title
Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function
Authors
Zahra Fatehi-Hassanabad
Catherine B Chan
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Nutrition & Metabolism / Issue 1/2005
Electronic ISSN: 1743-7075
DOI
https://doi.org/10.1186/1743-7075-2-1

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