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Open Access 01-12-2011 | Research

Identification of a natural human serotype 3 parainfluenza virus

Authors: Hui-Ting Yang, Qing Jiang, Xu Zhou, Mu-Qun Bai, Hong-Li Si, Xiao-Jing Wang, Yan Lu, Heng Zhao, Hong-Bin He, Cheng-Qiang He

Published in: Virology Journal | Issue 1/2011

Abstract

Parainfluenza virus is an important pathogen threatening the health of animals and human, which brings human many kinds of disease, especially lower respiratory tract infection involving infants and young children. In order to control the virus, it is necessary to fully understand the molecular basis resulting in the genetic diversity of the virus. Homologous recombination is one of mechanisms for the rapid change of genetic diversity. However, as a negative-strand virus, it is unknown whether the recombination can naturally take place in human PIV. In this study, we isolated and identified a mosaic serotype 3 human PIV (HPIV3) from in China, and also provided several putative PIV mosaics from previous reports to reveal that the recombination can naturally occur in the virus. In addition, two swine PIV3 isolates transferred from cattle to pigs were found to have mosaic genomes. These results suggest that homologous recombination can promote the genetic diversity and potentially bring some novel biologic characteristics of HPIV.

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Title: Identification of a natural human serotype 3 parainfluenza virus
Authors: Hui-Ting Yang
Qing Jiang
Xu Zhou
Mu-Qun Bai
Hong-Li Si
Xiao-Jing Wang
Yan Lu
Heng Zhao
Hong-Bin He
Cheng-Qiang He
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2011
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/1743-422X-8-58

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