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Open Access 01-12-2010 | Short report

Human herpesvirus 6 infection impairs Toll-like receptor signaling

Authors: Yuichi Murakami, Kazushi Tanimoto, Hiroshi Fujiwara, Jun An, Koichiro Suemori, Toshiki Ochi, Hitoshi Hasegawa, Masaki Yasukawa

Published in: Virology Journal | Issue 1/2010

Abstract

Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against various pathogens. In the present study, we investigated the effect of HHV-6 infection on the expression and intracellular signaling of TLRs in DCs. Although expression levels of TLRs were not decreased or slightly elevated following HHV-6 infection, the amounts of cytokines produced following stimulation with ligands for TLRs appeared to be dramatically decreased in HHV-6-infected DCs as compared to mock-infected DCs. Similarly, phosphorylation levels of TAK-1, IκB kinase, and IκB-α following stimulation of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4, appeared to be decreased. These data show that HHV-6 impairs intracellular signaling through TLRs indicating the novel mechanism of HHV-6-mediated immunomodulation.

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Title: Human herpesvirus 6 infection impairs Toll-like receptor signaling
Authors: Yuichi Murakami
Kazushi Tanimoto
Hiroshi Fujiwara
Jun An
Koichiro Suemori
Toshiki Ochi
Hitoshi Hasegawa
Masaki Yasukawa
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2010
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/1743-422X-7-91

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