Published in:
Open Access
01-12-2010 | Short report
Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development
Authors:
Jee Eun Rhee, Mi Yeong Shin, Choong Mo Kim, Hye Young Kee, Jae Keun Chung, Sang-Kee Min, Seong-Joon Kim, Dai-Ho Jang, Sung Soon Kim, Byeong-Sun Choi
Published in:
Virology Journal
|
Issue 1/2010
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Abstract
We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women.