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Virology Journal
Published in: Virology Journal 1/2009

Open Access 01-12-2009 | Case Report

Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin's disease: a case report

Authors: Martin Bommer, Sandra Pauls, Jochen Greiner

Published in: Virology Journal | Issue 1/2009

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Abstract

Background

Reactivation of human herpesvirus 6 (HHV-6) occurs frequently in patients after allogeneic stem cell transplantation and is associated with bone-marrow suppression, enteritis, pneumonitis, pericarditis and also encephalitis. After autologous stem cell transplantation or intensive polychemotherapy HHV-6 reactivation is rarely reported.

Case report

This case demonstrates a severe symptomatic HHV-6 infection with encephalitis and pneumonitis after autologous stem cell transplantation of a patient with relapsed Hodgkin's disease.

Conclusion

Careful diagnostic work up in patients with severe complications after autologous stem cell transplantation is mandatory to identify uncommon infections.
Appendix
Available only for authorised users
Literature
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Volin L, Lautenschlager I, Juvonen E, Nihtinen A, Anttila VJ, Ruutu T: Human herpesvirus 6 antigenaemia in allogeneic stem cell transplant recipients: impact on clinical course and association with other beta-herpesviruses. Br J Haematol 2004, 126: 690-696. 10.1111/j.1365-2141.2004.05101.xCrossRefPubMed
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Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M: Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 2005, 40: 932-940. 10.1086/428060CrossRefPubMed
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Metadata
Title
Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin's disease: a case report
Authors
Martin Bommer
Sandra Pauls
Jochen Greiner
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2009
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-6-111

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