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Open Access 01-12-2013 | Research

Septic shock in older people: a prospective cohort study

Authors: Fabiano Pinheiro da Silva, Fernando Godinho Zampieri, Denise Frediani Barbeiro, Hermes Vieira Barbeiro, Alessandra Carvalho Goulart, Francisco Torggler Filho, Irineu Tadeu Velasco, Luiz Monteiro da Cruz Neto, Heraldo Possolo de Souza, Marcel Cerqueira César Machado

Published in: Immunity & Ageing | Issue 1/2013

Abstract

Background

Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals.

Results

Here, we describe a prospective cohort study designed to analyze the immune profile of this population.

Conclusion

Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection.

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Title: Septic shock in older people: a prospective cohort study
Authors: Fabiano Pinheiro da Silva
Fernando Godinho Zampieri
Denise Frediani Barbeiro
Hermes Vieira Barbeiro
Alessandra Carvalho Goulart
Francisco Torggler Filho
Irineu Tadeu Velasco
Luiz Monteiro da Cruz Neto
Heraldo Possolo de Souza
Marcel Cerqueira César Machado
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Immunity & Ageing / Issue 1/2013
Electronic ISSN: 1742-4933
DOI: https://doi.org/10.1186/1742-4933-10-21

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