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Open Access 01-12-2010 | Review

Notch signaling in glioblastoma: a developmental drug target?

Authors: Maria Maddalena Lino, Adrian Merlo, Jean-Louis Boulay

Published in: BMC Medicine | Issue 1/2010

Abstract

Malignant gliomas are among the most devastating tumors for which conventional therapies have not significantly improved patient outcome. Despite advances in imaging, surgery, chemotherapy and radiotherapy, survival is still less than 2 years from diagnosis and more targeted therapies are urgently needed. Notch signaling is central to the normal and neoplastic development of the central nervous system, playing important roles in proliferation, differentiation, apoptosis and cancer stem cell regulation. Notch is also involved in the regulation response to hypoxia and angiogenesis, which are typical tumor and more specifically glioblastoma multiforme (GBM) features. Targeting Notch signaling is therefore a promising strategy for developing future therapies for the treatment of GBM. In this review we give an overview of the mechanisms of Notch signaling, its networking pathways in gliomas, and discuss its potential for designing novel therapeutic approaches.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/8/72/prepub

Title: Notch signaling in glioblastoma: a developmental drug target?
Authors: Maria Maddalena Lino
Adrian Merlo
Jean-Louis Boulay
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2010
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-8-72

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Notch signaling in glioblastoma: a developmental drug target?

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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