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BMC Medicine
Published in: BMC Medicine 1/2010

Open Access 01-12-2010 | Commentary

Can metabolomics in addition to genomics add to prognostic and predictive information in breast cancer?

Author: Anthony Howell

Published in: BMC Medicine | Issue 1/2010

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Abstract

Genomic data from breast cancers provide additional prognostic and predictive information that is beginning to be used for patient management. The question arises whether additional information derived from other 'omic' approaches such as metabolomics can provide additional information. In an article published this month in BMC Cancer, Borgan et al. add metabolomic information to genomic measures in breast tumours and demonstrate, for the first time, that it may be possible to further define subgroups of patients which could be of value clinically.
See research article: http://​www.​biomedcentral.​com/​1471-2407/​10/​628
Literature
1.
Borgan E, Sitter B, Lingjaerde OL, Johnsen H, Lundgren S, Bathen TF, Sorlie T, Borresen-Dale AL, Gribbestad IS: Merging transcriptomics and metabolomics - advances in breast cancer profiling. BMC Cancer. 2010, 10: 628.CrossRefPubMedPubMedCentral
2.
Welji AM, Jirik FR: Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect. Int J Biochem and Cell Biol. 2010.
3.
Sitter B, Lundgren S, Bathen TF, Halgunset J, Fjosne HE, Gribbestad IS: Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters. NMR Biomed. 2006, 19: 30-40. 10.1002/nbm.992.CrossRefPubMed
4.
Chan ECY, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Keum HC: Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). Journal of Proteome Research. 2009, 8: 352-361. 10.1021/pr8006232.CrossRefPubMed
5.
Oakman C, Tenori L, Biganzoli L, Santarpia L, Cappadona S, Luchinat C, Di Leo A: Uncovering the metabolomic fingerprint of breast cancer. Int J Biochem Cell Biol. 2010.
6.
Wang H, Tso VK, Slupsky CM, Fedorak RN: Metabolomics and detection of colorectal cancer in humans: a systemactic review. Future Oncology. 2010, 6: 1395-1406. 10.2217/fon.10.107.CrossRefPubMed
7.
Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, Pavlides S, Whitaker-Menezes D, Tsirigos A, Witkiewwicz A, Lin Z, Balliet R, Howell A, Sotgia F: Understanding the 'lethal' drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biol Ther. 2010.
Metadata
Title
Can metabolomics in addition to genomics add to prognostic and predictive information in breast cancer?
Author
Anthony Howell
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2010
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-8-73

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