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BMC Medicine
Published in: BMC Medicine 1/2013

Open Access 01-12-2013 | Research article

Alcohol intake, wine consumption and the development of depression: the PREDIMED study

Authors: Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, for the PREDIMED GROUP

Published in: BMC Medicine | Issue 1/2013

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Abstract

Background

Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.

Methods

We followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial for up to seven years. Participants were initially free of depression or a history of depression, and did not have any history of alcohol-related problems. A 137-item validated food frequency questionnaire administered by a dietician was repeated annually to assess alcohol intake. Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression, and/or initiated the use of antidepressant drugs. Cox regression analyses were fitted over 23,655 person-years.

Results

Moderate alcohol intake within the range of 5 to 15 g/day was significantly associated with lower risk of incident depression (hazard ratio (HR) and 95% confidence interval (95% CI) = 0.72 (0.53 to 0.98) versus abstainers). Specifically, wine consumption in the range of two to seven drinks/week was significantly associated with lower rates of depression (HR (95% CI) = 0.68 (0.47 to 0.98)).

Conclusions

Moderate consumption of wine may reduce the incidence of depression, while heavy drinkers seem to be at higher risk.
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Metadata
Title
Alcohol intake, wine consumption and the development of depression: the PREDIMED study
Authors
Alfredo Gea
Juan J Beunza
Ramón Estruch
Almudena Sánchez-Villegas
Jordi Salas-Salvadó
Pilar Buil-Cosiales
Enrique Gómez-Gracia
María-Isabel Covas
Dolores Corella
Miquel Fiol
Fernando Arós
José Lapetra
Rosa-María Lamuela-Raventós
Julia Wärnberg
Xavier Pintó
Lluis Serra-Majem
Miguel A Martínez-González
for the PREDIMED GROUP
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-11-192

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