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Published in: Allergy, Asthma & Clinical Immunology 1/2010

Open Access 01-12-2010 | Review

Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions

Author: Karen E Binkley

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2010

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Abstract

The clinical, biochemical and genetic features of the conditions known as estrogen-dependent inherited angioedema, estrogen-associated angioedema, hereditary angioedema with normal C-1 inhibitor, type III angioedema, or factor XII angioedema are reviewed. Discussion emphasizes pathogenesis, diagnosis, and management.
Literature
1.
go back to reference Binkley KE, Davis A: Clinical, biochemical, and genetic characterization of a novel estrogen-dependent inherited form of angioedema. J Allergy Clin Immunol. 2000, 106: 546-50. 10.1067/mai.2000.108106.CrossRefPubMed Binkley KE, Davis A: Clinical, biochemical, and genetic characterization of a novel estrogen-dependent inherited form of angioedema. J Allergy Clin Immunol. 2000, 106: 546-50. 10.1067/mai.2000.108106.CrossRefPubMed
2.
go back to reference Bork K, Barnstedt SE, Koch P, Traupe H: Hereditary angioedema with normal C1-inhibitor activity in women. Lancet. 2000, 356: 213-7. 10.1016/S0140-6736(00)02483-1.CrossRefPubMed Bork K, Barnstedt SE, Koch P, Traupe H: Hereditary angioedema with normal C1-inhibitor activity in women. Lancet. 2000, 356: 213-7. 10.1016/S0140-6736(00)02483-1.CrossRefPubMed
3.
go back to reference Martin L, Degenene D, Toutain A, Ponard D, Watier H: Hereditary angioedema type III: an additional French pedigree with autosomal dominant transmission. J Allergy Clin Immunol. 2001, 107: 747-8. 10.1067/mai.2001.114242.CrossRefPubMed Martin L, Degenene D, Toutain A, Ponard D, Watier H: Hereditary angioedema type III: an additional French pedigree with autosomal dominant transmission. J Allergy Clin Immunol. 2001, 107: 747-8. 10.1067/mai.2001.114242.CrossRefPubMed
4.
go back to reference Herrmann G, Schneider L, Krieg T, Hunzelmann N, Scharfetter-Kochanek K: Efficacy of danazol treatment in a patient with a new variant of hereditary angiooedema (HAE III). Br J Dermatol. 2004, 150: 157-8. 10.1111/j.1365-2133.2004.05669.x.CrossRefPubMed Herrmann G, Schneider L, Krieg T, Hunzelmann N, Scharfetter-Kochanek K: Efficacy of danazol treatment in a patient with a new variant of hereditary angiooedema (HAE III). Br J Dermatol. 2004, 150: 157-8. 10.1111/j.1365-2133.2004.05669.x.CrossRefPubMed
5.
go back to reference Bouillet L, Ponard D, Rousset H, Cichon S, Drouet C: A case of hereditary angioedema type III presenting with C1-inhibitor cleavage and a missense mutation in the F12 gene. Br J Dermatol. 2007, 156: 1063-5. 10.1111/j.1365-2133.2007.07778.x.CrossRefPubMed Bouillet L, Ponard D, Rousset H, Cichon S, Drouet C: A case of hereditary angioedema type III presenting with C1-inhibitor cleavage and a missense mutation in the F12 gene. Br J Dermatol. 2007, 156: 1063-5. 10.1111/j.1365-2133.2007.07778.x.CrossRefPubMed
6.
go back to reference Fiz Matias J, Ferrer Ceron SM, Garcia Perez C, Marcos Vidal JM: Analgesia obstetrica en un caso de edema angioneurotico hereditario tipo III. Rev Esp Anestesiol Reanim. 2007, 54: 253-4.PubMed Fiz Matias J, Ferrer Ceron SM, Garcia Perez C, Marcos Vidal JM: Analgesia obstetrica en un caso de edema angioneurotico hereditario tipo III. Rev Esp Anestesiol Reanim. 2007, 54: 253-4.PubMed
7.
go back to reference Serrano C, Guilarte M, Tella R, Dalmau G, Bartra J, Gaig P, Cerda M, Cardona V, Valero A: Oestrogen-dependent hereditary angiooedema with normal C1 inhibitor: description of six new cases and review of pathogenic mechanisms and treatment. Allergy. 2008, 63: 735-41. 10.1111/j.1398-9995.2007.01579.x.CrossRefPubMed Serrano C, Guilarte M, Tella R, Dalmau G, Bartra J, Gaig P, Cerda M, Cardona V, Valero A: Oestrogen-dependent hereditary angiooedema with normal C1 inhibitor: description of six new cases and review of pathogenic mechanisms and treatment. Allergy. 2008, 63: 735-41. 10.1111/j.1398-9995.2007.01579.x.CrossRefPubMed
8.
go back to reference Cyr M, Eastlund T, Blais C, Rouleau JL, Adam A: Bradykinin metabolism and hypotensive transfusion reactions. Transfusion. 2001, 41: 136-50. 10.1046/j.1537-2995.2001.41010136.x.CrossRefPubMed Cyr M, Eastlund T, Blais C, Rouleau JL, Adam A: Bradykinin metabolism and hypotensive transfusion reactions. Transfusion. 2001, 41: 136-50. 10.1046/j.1537-2995.2001.41010136.x.CrossRefPubMed
9.
go back to reference Davis AE: The pathogenesis of hereditary angioedema. Transfus Apheresis Sci. 2003, 29: 195-203. 10.1016/j.transci.2003.08.012.CrossRef Davis AE: The pathogenesis of hereditary angioedema. Transfus Apheresis Sci. 2003, 29: 195-203. 10.1016/j.transci.2003.08.012.CrossRef
10.
go back to reference Davis AE: C1 inhibitor and hereditary angioneurotic edema. Ann Rev Immunol. 1988, 6: 595-628. 10.1146/annurev.iy.06.040188.003115.CrossRef Davis AE: C1 inhibitor and hereditary angioneurotic edema. Ann Rev Immunol. 1988, 6: 595-628. 10.1146/annurev.iy.06.040188.003115.CrossRef
11.
go back to reference Dewald G, Bork K: Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor. Biochem Biophys Res Commun. 2006, 343: 1286-9. 10.1016/j.bbrc.2006.03.092.CrossRefPubMed Dewald G, Bork K: Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor. Biochem Biophys Res Commun. 2006, 343: 1286-9. 10.1016/j.bbrc.2006.03.092.CrossRefPubMed
12.
go back to reference Cichon S, Martin L, Hennies HC, Muller F, Van Driessche K, Karpushova A, Stevens W, Colombo R, Renne T, Drouet C, Bork K, Nothen MM: Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III. Am J Hum Genet. 2006, 79: 1098-104. 10.1086/509899.PubMedCentralCrossRefPubMed Cichon S, Martin L, Hennies HC, Muller F, Van Driessche K, Karpushova A, Stevens W, Colombo R, Renne T, Drouet C, Bork K, Nothen MM: Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III. Am J Hum Genet. 2006, 79: 1098-104. 10.1086/509899.PubMedCentralCrossRefPubMed
13.
go back to reference Bork K, Gul D, Dewald G: Hereditary angioedema with normal C1 inhibitor in a family with affected women and men. Br J Dermatol. 2006, 154: 542-5. 10.1111/j.1365-2133.2005.07048.x.CrossRefPubMed Bork K, Gul D, Dewald G: Hereditary angioedema with normal C1 inhibitor in a family with affected women and men. Br J Dermatol. 2006, 154: 542-5. 10.1111/j.1365-2133.2005.07048.x.CrossRefPubMed
14.
go back to reference Bork K, Gul D, Hardt J, Dewald G: Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course. Am J Med. 2007, 120: 987-92. 10.1016/j.amjmed.2007.08.021.CrossRefPubMed Bork K, Gul D, Hardt J, Dewald G: Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course. Am J Med. 2007, 120: 987-92. 10.1016/j.amjmed.2007.08.021.CrossRefPubMed
15.
go back to reference Martin L, Raison-Peyron N, Nothen MM, Cichon S, Drouet C: Hereditary Angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 gene. J Allergy Clin Immunol. 2007, 120: 975-7. 10.1016/j.jaci.2007.07.002.CrossRefPubMed Martin L, Raison-Peyron N, Nothen MM, Cichon S, Drouet C: Hereditary Angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 gene. J Allergy Clin Immunol. 2007, 120: 975-7. 10.1016/j.jaci.2007.07.002.CrossRefPubMed
16.
go back to reference Bork K, Wulff K, Hardt J, Witzke G, Staubach P: Hereditary angioedema caused by missense mutations in the factor XII gene: clinical features, trigger factors, and therapy. J Allergy Clin Immunol. 2009, 124: 129-34. 10.1016/j.jaci.2009.03.038.CrossRefPubMed Bork K, Wulff K, Hardt J, Witzke G, Staubach P: Hereditary angioedema caused by missense mutations in the factor XII gene: clinical features, trigger factors, and therapy. J Allergy Clin Immunol. 2009, 124: 129-34. 10.1016/j.jaci.2009.03.038.CrossRefPubMed
17.
go back to reference Duan QL, Binkley K, Rouleau GA: Genetic analysis of factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema. J Allergy Clin Immunol. 2009, 123: 906-10. 10.1016/j.jaci.2008.12.010.CrossRefPubMed Duan QL, Binkley K, Rouleau GA: Genetic analysis of factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema. J Allergy Clin Immunol. 2009, 123: 906-10. 10.1016/j.jaci.2008.12.010.CrossRefPubMed
18.
go back to reference Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990, 86: 1343-6. 10.1172/JCI114844.PubMedCentralCrossRefPubMed Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990, 86: 1343-6. 10.1172/JCI114844.PubMedCentralCrossRefPubMed
19.
go back to reference Murphey LJ, Hachey DL, Oates JA, Morrow JD, Brown NJ: Metabolism of bradykininin vivo in humans: identification of BK1-5 as a stable plasma peptide metabolite. J Pharmacol Exp Ther. 2000, 294: 263-9.PubMed Murphey LJ, Hachey DL, Oates JA, Morrow JD, Brown NJ: Metabolism of bradykininin vivo in humans: identification of BK1-5 as a stable plasma peptide metabolite. J Pharmacol Exp Ther. 2000, 294: 263-9.PubMed
20.
go back to reference Duan QL, Nikpoor B, Dube MP, Molinaro G, Meijer IA, Dion P, Rochfort D, Saint- Onge J, Flury L, Brown NJ, Gainer JV, Rouleau JL, Agostini A, Cugno M, Simon P, Clavel P, Potier J, Webhe B, Bernarbis S, Marc-Aurele J, Chanard J, Foroud T, Adam A, Rouleau GA: A variant inXPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 2005, 77: 617-26. 10.1086/496899.PubMedCentralCrossRefPubMed Duan QL, Nikpoor B, Dube MP, Molinaro G, Meijer IA, Dion P, Rochfort D, Saint- Onge J, Flury L, Brown NJ, Gainer JV, Rouleau JL, Agostini A, Cugno M, Simon P, Clavel P, Potier J, Webhe B, Bernarbis S, Marc-Aurele J, Chanard J, Foroud T, Adam A, Rouleau GA: A variant inXPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 2005, 77: 617-26. 10.1086/496899.PubMedCentralCrossRefPubMed
21.
go back to reference Molinaro G, Duan QL, Chagnon M, Moreau ME, Simon P, Clavel P, Lavaud S, Boileau G, Rouleau GA, Lepage Y, Adam A, Chanard J: Kinin dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors. Kidney Int. 2006, 70: 1823-31. 10.1038/sj.ki.5001873.CrossRefPubMed Molinaro G, Duan QL, Chagnon M, Moreau ME, Simon P, Clavel P, Lavaud S, Boileau G, Rouleau GA, Lepage Y, Adam A, Chanard J: Kinin dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors. Kidney Int. 2006, 70: 1823-31. 10.1038/sj.ki.5001873.CrossRefPubMed
22.
go back to reference Bell CG, Kwan E, Nolan RC, Baumgart KW: First molecular confirmation of an Australian case of type III hereditary angioedema. Pathology. 2008, 40: 82-3. 10.1080/00313020701716433.CrossRefPubMed Bell CG, Kwan E, Nolan RC, Baumgart KW: First molecular confirmation of an Australian case of type III hereditary angioedema. Pathology. 2008, 40: 82-3. 10.1080/00313020701716433.CrossRefPubMed
23.
go back to reference Hentges F, Hilger C, Kohnen M, Gilson G: Angioedema and estrogen-dependent angioedema with activation of the contact system. J Allergy Immunol Clin. 2009, 123: 262-4. 10.1016/j.jaci.2008.10.056.CrossRef Hentges F, Hilger C, Kohnen M, Gilson G: Angioedema and estrogen-dependent angioedema with activation of the contact system. J Allergy Immunol Clin. 2009, 123: 262-4. 10.1016/j.jaci.2008.10.056.CrossRef
24.
go back to reference Blais C, Rouleau JL, Brown NJ, Lepage Y, Spence D, Munoz C, Friborg J, Geadah D, Gervais N, Adam A: Serum metabolism of bradykinin and des-Arg9-bradykinin in patients with angiotensin-converting enzyme inhibitor-associated angioedema. Immunopharmacology. 1999, 43 (2-3): 293-302. 10.1016/S0162-3109(99)00133-2.CrossRefPubMed Blais C, Rouleau JL, Brown NJ, Lepage Y, Spence D, Munoz C, Friborg J, Geadah D, Gervais N, Adam A: Serum metabolism of bradykinin and des-Arg9-bradykinin in patients with angiotensin-converting enzyme inhibitor-associated angioedema. Immunopharmacology. 1999, 43 (2-3): 293-302. 10.1016/S0162-3109(99)00133-2.CrossRefPubMed
25.
go back to reference Molinaro G, Cugno M, Perez M, Lepage Y, Gervais N, Agostoni A, Adam A: Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin. J Pharmacol Exp Ther. 2002, 303 (1): 232-7. 10.1124/jpet.102.038067.CrossRefPubMed Molinaro G, Cugno M, Perez M, Lepage Y, Gervais N, Agostoni A, Adam A: Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin. J Pharmacol Exp Ther. 2002, 303 (1): 232-7. 10.1124/jpet.102.038067.CrossRefPubMed
26.
go back to reference Strauss JF, Barbieri R, editors: Yen and Yaffe's Reproductive Endocrinology. 2009, Saunders Elselvier, Chapter 4: 79-104. Sixth Strauss JF, Barbieri R, editors: Yen and Yaffe's Reproductive Endocrinology. 2009, Saunders Elselvier, Chapter 4: 79-104. Sixth
27.
go back to reference Schwarz S, Tappeiner G, Hintner H: Hormone binding globulin levels in patients with hereditary angiooedema during treatment with Danazol. Clin Endocrinol (Oxf). 1981, 14 (6): 563-70. 10.1111/j.1365-2265.1981.tb02966.x.CrossRef Schwarz S, Tappeiner G, Hintner H: Hormone binding globulin levels in patients with hereditary angiooedema during treatment with Danazol. Clin Endocrinol (Oxf). 1981, 14 (6): 563-70. 10.1111/j.1365-2265.1981.tb02966.x.CrossRef
28.
go back to reference Visy B, Fust G, Varga L, Szendei G, Takacs E, Karadi I, Fekete B, Harmat G, Farkas H: Sex hormones in hereditary angioneurotic oedema. Clin Endocrinol. 2004, 60 (4): 508-15. 10.1111/j.1365-2265.2004.02009.x.CrossRef Visy B, Fust G, Varga L, Szendei G, Takacs E, Karadi I, Fekete B, Harmat G, Farkas H: Sex hormones in hereditary angioneurotic oedema. Clin Endocrinol. 2004, 60 (4): 508-15. 10.1111/j.1365-2265.2004.02009.x.CrossRef
29.
go back to reference Gordon EM, Ratnoff OD, Saito H, Donaldson VH, Pensky J, Jones PK: Rapid fibrinolysis, augmented Hageman factor (factor XII) titres and decreased C1 esterase inhibitor titres in women taking oral contraceptives. J Lab Clin Med. 1980, 96: 762-9.PubMed Gordon EM, Ratnoff OD, Saito H, Donaldson VH, Pensky J, Jones PK: Rapid fibrinolysis, augmented Hageman factor (factor XII) titres and decreased C1 esterase inhibitor titres in women taking oral contraceptives. J Lab Clin Med. 1980, 96: 762-9.PubMed
30.
go back to reference Gordon EM, Williams SR, Frencheck B, Mazur CA, Speroff I: Dose dependent effects of postmenopausal estrogen and progestin on antithrombin III and factor XII. J Lab Clin Med. 1988, 111: 52-6.PubMed Gordon EM, Williams SR, Frencheck B, Mazur CA, Speroff I: Dose dependent effects of postmenopausal estrogen and progestin on antithrombin III and factor XII. J Lab Clin Med. 1988, 111: 52-6.PubMed
31.
go back to reference Klein-Hitpass L, Tsai SY, Greene GL, Clark JH, Tsai MJ, O'Malley BW: Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol. 1989, 9: 43-9.PubMedCentralCrossRefPubMed Klein-Hitpass L, Tsai SY, Greene GL, Clark JH, Tsai MJ, O'Malley BW: Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol. 1989, 9: 43-9.PubMedCentralCrossRefPubMed
32.
go back to reference Farsetti A, Misiti S, Citarella F, Felici A, Andreoli M, Fantoni A, Sacchi A, Pontecorvi A: Molecular basis of estrogen regulation of Hageman factor XII gene expression. Endocrinology. 1995, 136: 5076-83. 10.1210/en.136.11.5076.PubMed Farsetti A, Misiti S, Citarella F, Felici A, Andreoli M, Fantoni A, Sacchi A, Pontecorvi A: Molecular basis of estrogen regulation of Hageman factor XII gene expression. Endocrinology. 1995, 136: 5076-83. 10.1210/en.136.11.5076.PubMed
33.
go back to reference Ogston D, Walker J, Campbell DM: C1 inactivator level in pregnancy. Thromb Res. 1981, 23: 454-5. 10.1016/0049-3848(81)90206-1. Ogston D, Walker J, Campbell DM: C1 inactivator level in pregnancy. Thromb Res. 1981, 23: 454-5. 10.1016/0049-3848(81)90206-1.
34.
go back to reference Halbmayer WM, Hopmeier P, Mannhalter C, Heuss F, Leodolter S, Rubi K, Fischer M: C1 esterase inhibitor in uncomplicated pregnancy and mild and moderate preeclampsia. Thromb Haemost. 1991, 2: 134-8. Halbmayer WM, Hopmeier P, Mannhalter C, Heuss F, Leodolter S, Rubi K, Fischer M: C1 esterase inhibitor in uncomplicated pregnancy and mild and moderate preeclampsia. Thromb Haemost. 1991, 2: 134-8.
35.
go back to reference Cohen AJ, Laskin C, Tarlo S: C1 esterase inhibitor in pregnancy. J AllergyClin Immunol. 1992, 90: 412-3. 10.1016/S0091-6749(05)80025-9.CrossRef Cohen AJ, Laskin C, Tarlo S: C1 esterase inhibitor in pregnancy. J AllergyClin Immunol. 1992, 90: 412-3. 10.1016/S0091-6749(05)80025-9.CrossRef
36.
go back to reference Jespersen J, Kluft C: Increased englobulin fibrinolytic potential in women on oral contraceptives low in oestrogen levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII and C1 inactivator. Thromb Haemost. 1985, 54: 454-9.PubMed Jespersen J, Kluft C: Increased englobulin fibrinolytic potential in women on oral contraceptives low in oestrogen levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII and C1 inactivator. Thromb Haemost. 1985, 54: 454-9.PubMed
37.
go back to reference Stevenson JC, Olatdipo A, Manassiev N, Whitehead MI, Guilford S, Proudler AJ: Randomized trial of effect of transdermal cutaneous combined hormone replacement therapy on cardiovascular risk markers. B J Haematol. 2004, 124: 802-8. 10.1111/j.1365-2141.2004.04846.x.CrossRef Stevenson JC, Olatdipo A, Manassiev N, Whitehead MI, Guilford S, Proudler AJ: Randomized trial of effect of transdermal cutaneous combined hormone replacement therapy on cardiovascular risk markers. B J Haematol. 2004, 124: 802-8. 10.1111/j.1365-2141.2004.04846.x.CrossRef
38.
go back to reference Drouet C, Desormeaux A, Robillard J, Ponard D, Bouillet L, Martin L, Kanny G, Moneret-Vautrin DA, Bosson JL, Quesada JL, López-Trascasa M: Metallopeptidase activities in hereditary angioedema: effect androgen prophylaxis on plasma aminopeptidase P. J Allergy Clin Immunol. 2008, 121: 429-33. 10.1016/j.jaci.2007.10.048.PubMedCentralCrossRefPubMed Drouet C, Desormeaux A, Robillard J, Ponard D, Bouillet L, Martin L, Kanny G, Moneret-Vautrin DA, Bosson JL, Quesada JL, López-Trascasa M: Metallopeptidase activities in hereditary angioedema: effect androgen prophylaxis on plasma aminopeptidase P. J Allergy Clin Immunol. 2008, 121: 429-33. 10.1016/j.jaci.2007.10.048.PubMedCentralCrossRefPubMed
39.
go back to reference Gelfand JA, Sherins RJ, Alling DW, Frank MM: Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med. 1976, 295: 1444-8. 10.1056/NEJM197612232952602.CrossRefPubMed Gelfand JA, Sherins RJ, Alling DW, Frank MM: Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med. 1976, 295: 1444-8. 10.1056/NEJM197612232952602.CrossRefPubMed
40.
go back to reference Cicardi M, Zingale L: Clinical manifestations of hereditary angioedema. J Allergy Clin Immunol. 2004, 114 (Suppl): S55-8. Cicardi M, Zingale L: Clinical manifestations of hereditary angioedema. J Allergy Clin Immunol. 2004, 114 (Suppl): S55-8.
41.
go back to reference Nobukata H, Katsuki Y, Ishikawa T, Inokuma M, Shibutani Y: Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Toxicol Lett. 1999, 104 (1-2): 93-101. 10.1016/S0378-4274(98)00354-3.CrossRefPubMed Nobukata H, Katsuki Y, Ishikawa T, Inokuma M, Shibutani Y: Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Toxicol Lett. 1999, 104 (1-2): 93-101. 10.1016/S0378-4274(98)00354-3.CrossRefPubMed
42.
go back to reference Freshour JR, Chase SE, Vikstrom KL: Gender differences in cardiac ACE expression are normalized in androgen-deprived male mice. Am J Physiol Heart Circ Physiol. 2002, 283 (5): H1997-2003.CrossRefPubMed Freshour JR, Chase SE, Vikstrom KL: Gender differences in cardiac ACE expression are normalized in androgen-deprived male mice. Am J Physiol Heart Circ Physiol. 2002, 283 (5): H1997-2003.CrossRefPubMed
43.
go back to reference Lim YK, Retnam L, Bhaqavath B, Sethi SK, bin Ali A, Lim SK: Gonadal effects on plasma ACE activity in mice. Atherosclerosis. 2002, 160 (2): 311-6. 10.1016/S0021-9150(01)00576-7.CrossRefPubMed Lim YK, Retnam L, Bhaqavath B, Sethi SK, bin Ali A, Lim SK: Gonadal effects on plasma ACE activity in mice. Atherosclerosis. 2002, 160 (2): 311-6. 10.1016/S0021-9150(01)00576-7.CrossRefPubMed
44.
go back to reference Bowen T, Cicardi M, Bork K, Zuraw B, Frank M, Ritchie B, Farkas H, Varga L, Zingale LC, Binkley K, Wagner E, Adomaitis P, Brosz K, Burnham J, Warrington R, Kalicinsky C, Mace S, McCusker C, Schellenberg R, Celeste L, Hebert J, Valentine K, Poon MC, Serushago B, Neurath D, Yang W, Lacuesta G, Issekutz A, Hamed A, Kamra P, Dean J, Kanani A, Stark D, Rivard GE, Leith E, Tsai E, Waserman S, Keith PK, Page D, Marchesin S, Longhurst HJ, Kreuz W, Rusicke E, Martinez-Saguer I, Aygören-Pürsün E, Harmat G, Füst G, Li H, Bouillet L, Caballero T, Moldovan D, Späth PJ, Smith-Foltz S, Nagy I, Nielsen EW, Bucher C, Nordenfelt P, Xiang ZY: Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Ann Allergy Asthma Immunol. 2008, 100 (1 Suppl 2): S30-40. 10.1016/S1081-1206(10)60584-4.CrossRefPubMed Bowen T, Cicardi M, Bork K, Zuraw B, Frank M, Ritchie B, Farkas H, Varga L, Zingale LC, Binkley K, Wagner E, Adomaitis P, Brosz K, Burnham J, Warrington R, Kalicinsky C, Mace S, McCusker C, Schellenberg R, Celeste L, Hebert J, Valentine K, Poon MC, Serushago B, Neurath D, Yang W, Lacuesta G, Issekutz A, Hamed A, Kamra P, Dean J, Kanani A, Stark D, Rivard GE, Leith E, Tsai E, Waserman S, Keith PK, Page D, Marchesin S, Longhurst HJ, Kreuz W, Rusicke E, Martinez-Saguer I, Aygören-Pürsün E, Harmat G, Füst G, Li H, Bouillet L, Caballero T, Moldovan D, Späth PJ, Smith-Foltz S, Nagy I, Nielsen EW, Bucher C, Nordenfelt P, Xiang ZY: Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Ann Allergy Asthma Immunol. 2008, 100 (1 Suppl 2): S30-40. 10.1016/S1081-1206(10)60584-4.CrossRefPubMed
45.
go back to reference Pickering RJ, Good RA, Kelly JR, Gewurz H: Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma. Lancet. 1969, 1: 326-30. 10.1016/S0140-6736(69)91295-1.CrossRefPubMed Pickering RJ, Good RA, Kelly JR, Gewurz H: Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma. Lancet. 1969, 1: 326-30. 10.1016/S0140-6736(69)91295-1.CrossRefPubMed
46.
go back to reference Ladner R, Kent R, Ley A, Nixon A, Sexton D: Discovery of Ecallantide: A Potent and Selective Inhibitor of Plasma Kallikrein. J Allergy Clin Immunol. 2007, 119 (S1): S312-10.1016/j.jaci.2006.12.591.CrossRef Ladner R, Kent R, Ley A, Nixon A, Sexton D: Discovery of Ecallantide: A Potent and Selective Inhibitor of Plasma Kallikrein. J Allergy Clin Immunol. 2007, 119 (S1): S312-10.1016/j.jaci.2006.12.591.CrossRef
47.
go back to reference MacGinnitie AJ, Pullman WE, Horn PT: Interim Results from Continuation-the Ongoing, Open-Label, Extension Study of Ecallantide for the Treatment of Acute Attacks of Hereditary Angioedema. J Allergy Clin Immunol. 2010, 2 (S1): AB165- MacGinnitie AJ, Pullman WE, Horn PT: Interim Results from Continuation-the Ongoing, Open-Label, Extension Study of Ecallantide for the Treatment of Acute Attacks of Hereditary Angioedema. J Allergy Clin Immunol. 2010, 2 (S1): AB165-
48.
go back to reference Bork K, Frank J, Grundt B, Schlattmann P, Nussberger J, Kreuz W: Treatment of acute edema at this is hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). J Allergy Clin Immunol. 2007, 119: 1497-1503. 10.1016/j.jaci.2007.02.012.CrossRefPubMed Bork K, Frank J, Grundt B, Schlattmann P, Nussberger J, Kreuz W: Treatment of acute edema at this is hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). J Allergy Clin Immunol. 2007, 119: 1497-1503. 10.1016/j.jaci.2007.02.012.CrossRefPubMed
49.
go back to reference Bouillet L, Boccon-Gibod I, Ponard D, Drouet C, Cesbron JY, Dumestre-Perard C, Monnier N, Lunardi J, Massot C, Gompel A: Bradykinin receptor 2 antagonist (icatibant) for hereditary angioedema type III attacks. Ann Allergy Asthma Immunol. 2009, 103: 448-10.1016/S1081-1206(10)60369-9.CrossRefPubMed Bouillet L, Boccon-Gibod I, Ponard D, Drouet C, Cesbron JY, Dumestre-Perard C, Monnier N, Lunardi J, Massot C, Gompel A: Bradykinin receptor 2 antagonist (icatibant) for hereditary angioedema type III attacks. Ann Allergy Asthma Immunol. 2009, 103: 448-10.1016/S1081-1206(10)60369-9.CrossRefPubMed
Metadata
Title
Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions
Author
Karen E Binkley
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Allergy, Asthma & Clinical Immunology / Issue 1/2010
Electronic ISSN: 1710-1492
DOI
https://doi.org/10.1186/1710-1492-6-16

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