Published in:
Open Access
01-03-2014 | Meeting abstract
Human rhinovirus infection of human bronchial epithelial cells results in migration of human airway smooth muscle cells
Authors:
Sami Shariff, Sergei Nikitenko, Abid Qureshi, Jason Arnason, Chris Shelfoon, Suzanne Traves, David Proud, Richard Leigh
Published in:
Allergy, Asthma & Clinical Immunology
|
Special Issue 1/2014
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Excerpt
Young children who experience human rhinovirus (HRV)-associated wheezing illnesses are more likely to develop subsequent asthma [
1]. This has led to the hypothesis that HRV infection may be involved in the pathogenesis of airway remodeling in asthma [
2]. Increased airway smooth muscle (ASM) mass, in which ASM cells are in close proximity to the subepithelial region, is a characteristic feature of airway remodeling [
3]. We have shown that HRV infection of human bronchial epithelial (HBE) cells, both
in vitro and
in vivo, results in the upregulation of airway remodeling mediators [
4]. We now sought to determine whether HRV infection of HBE cells is associated with airway smooth muscle (ASM) chemotaxis. …
