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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2014

Open Access 01-03-2014 | Meeting abstract

Thymic stromal lymphopoietin promotes human eosinophil-basophil lineage commitment: a key role for tumor necrosis factor-alpha

Authors: Claudia CK Hui, Sina Rusta-Sallehy, Delia Heroux, Judah A Denburg

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 1/2014

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Excerpt

Allergic diseases are characterized by tissue eosinophilic and basophilic inflammation. Both epithelial-derived thymic stromal lymphopoietin (TSLP) and eosinophil/basophil (Eo/B) lineage-committed progenitor cells are upregulated and found at sites of allergic inflammation [1‐3]. We have previously shown that TSLP mediates the differentiation of peripheral blood (PB) CD34+ progenitor cells into eosinophils and basophils. However, the specific mechanisms through which TSLP promotes this lineage commitment are unclear. The aim of this study is to characterize the intracellular mechanisms by which TSLP mediates Eo/B differentiation. …
Literature
1.
Ying S, O'Connor B, Ratoff J, Meng Q, Mallett K, Cousins D: Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol. 2005, 174: 8183-90.CrossRefPubMed
2.
Robinson DS, Damia R, Zeibecoglou K, Molet S, North J, Yamada T: CD34(+)/interleukin-5Ralpha messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors. Am J Respir Cell Mol Biol. 1999, 20: 9-13.CrossRefPubMed
3.
Kim YK, Uno M, Hamilos DL, Beck L, Bochner B, Schleimer R: Immunolocalization of CD34 in nasal polyposis. Effect of topical corticosteroids. Am J Respir Cell Mol Biol. 1999, 20: 388-97.CrossRefPubMed
Metadata
Title
Thymic stromal lymphopoietin promotes human eosinophil-basophil lineage commitment: a key role for tumor necrosis factor-alpha
Authors
Claudia CK Hui
Sina Rusta-Sallehy
Delia Heroux
Judah A Denburg
Publication date
01-03-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1710-1492-10-S1-A51

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