Skip to main content
Top
Published in: Journal of the International Society of Sports Nutrition 1/2010

Open Access 01-12-2010 | Research article

Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial

Authors: Kerry S Kuehl, Erica T Perrier, Diane L Elliot, James C Chesnutt

Published in: Journal of the International Society of Sports Nutrition | Issue 1/2010

Login to get access

Abstract

Background

Long distance running causes acute muscle damage resulting in inflammation and decreased force production. Endurance athletes use NSAIDs during competition to prevent or reduce pain, which carries the risk of adverse effects. Tart cherries, rich in antioxidant and anti-inflammatory properties, may have a protective effect to reduce muscle damage and pain during strenuous exercise. This study aimed to assess the effects of tart cherry juice as compared to a placebo cherry drink on pain among runners in a long distance relay race.

Methods

The design was a randomized, double blind, placebo controlled trial. Fifty-four healthy runners (36 male, 18 female; 35.8 ± 9.6 yrs) ran an average of 26.3 ± 2.5 km over a 24 hour period. Participants ingested 355 mL bottles of tart cherry juice or placebo cherry drink twice daily for 7 days prior to the event and on the day of the race. Participants assessed level of pain on a standard 100 mm Visual Analog Scale (VAS) at baseline, before the race, and after the race.

Results

While both groups reported increased pain after the race, the cherry juice group reported a significantly smaller increase in pain (12 ± 18 mm) compared to the placebo group (37 ± 20 mm) (p < .001). Participants in the cherry juice group were more willing to use the drink in the future (p < 0.001) and reported higher satisfaction with the pain reduction they attributed to the drink (p < 0.001).

Conclusions

Ingesting tart cherry juice for 7 days prior to and during a strenuous running event can minimize post-run muscle pain.
Appendix
Available only for authorised users
Literature
1.
go back to reference Papassotiriou I, Alexiou VG, Tsironi M, Skenderi K, Spanos A, Falagas ME: Severe aseptic inflammation caused by long distance running (246 km) does not increase procalcitonin. Eur J Clin Invest. 2008, 38: 276-279. 10.1111/j.1365-2362.2008.01935.x.CrossRefPubMed Papassotiriou I, Alexiou VG, Tsironi M, Skenderi K, Spanos A, Falagas ME: Severe aseptic inflammation caused by long distance running (246 km) does not increase procalcitonin. Eur J Clin Invest. 2008, 38: 276-279. 10.1111/j.1365-2362.2008.01935.x.CrossRefPubMed
2.
go back to reference Millet GY, Lepers R: Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sports Med. 2004, 34: 105-116. 10.2165/00007256-200434020-00004.CrossRefPubMed Millet GY, Lepers R: Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sports Med. 2004, 34: 105-116. 10.2165/00007256-200434020-00004.CrossRefPubMed
3.
go back to reference Kobayashi Y, Takeuchi T, Hosoi T, Yoshizaki H, Loeppky JA: Effect of a marathon run on serum lipoproteins, creatine kinase, and lactate dehydrogenase in recreational runners. Res Q Exerc Sport. 2005, 76: 450-455.CrossRefPubMed Kobayashi Y, Takeuchi T, Hosoi T, Yoshizaki H, Loeppky JA: Effect of a marathon run on serum lipoproteins, creatine kinase, and lactate dehydrogenase in recreational runners. Res Q Exerc Sport. 2005, 76: 450-455.CrossRefPubMed
4.
go back to reference Cleak MJ, Eston RG: Muscle soreness, swelling, stiffness and strength loss after intense eccentric exercise. Br J Sports Med. 1992, 26: 267-272. 10.1136/bjsm.26.4.267.PubMedCentralCrossRefPubMed Cleak MJ, Eston RG: Muscle soreness, swelling, stiffness and strength loss after intense eccentric exercise. Br J Sports Med. 1992, 26: 267-272. 10.1136/bjsm.26.4.267.PubMedCentralCrossRefPubMed
5.
go back to reference Newham DJ, Jones DA, Ghosh G, Aurora P: Muscle fatigue and pain after eccentric contractions at long and short length. Clin Sci (Lond). 1988, 74: 553-557.CrossRef Newham DJ, Jones DA, Ghosh G, Aurora P: Muscle fatigue and pain after eccentric contractions at long and short length. Clin Sci (Lond). 1988, 74: 553-557.CrossRef
6.
go back to reference Newham DJ, Mills KR, Quigley BM, Edwards RH: Pain and fatigue after concentric and eccentric muscle contractions. Clin Sci (Lond). 1983, 64: 55-62.CrossRef Newham DJ, Mills KR, Quigley BM, Edwards RH: Pain and fatigue after concentric and eccentric muscle contractions. Clin Sci (Lond). 1983, 64: 55-62.CrossRef
7.
go back to reference Clarkson PM, Byrnes WC, Gillisson E, Harper E: Adaptation to exercise-induced muscle damage. Clin Sci (Lond). 1987, 73: 383-386.CrossRef Clarkson PM, Byrnes WC, Gillisson E, Harper E: Adaptation to exercise-induced muscle damage. Clin Sci (Lond). 1987, 73: 383-386.CrossRef
8.
go back to reference McHugh MP, Pasiakos S: The role of exercising muscle length in the protective adaptation to a single bout of eccentric exercise. Eur J Appl Physiol. 2004, 93: 286-293. 10.1007/s00421-004-1196-0.CrossRefPubMed McHugh MP, Pasiakos S: The role of exercising muscle length in the protective adaptation to a single bout of eccentric exercise. Eur J Appl Physiol. 2004, 93: 286-293. 10.1007/s00421-004-1196-0.CrossRefPubMed
9.
go back to reference Tourville TW, Connolly DA, Reed BV: Effects of sensory-level high-volt pulsed electrical current ondelayed-onset muscle soreness. J Sports Sci. 2006, 24: 941-949. 10.1080/02640410500357226.CrossRefPubMed Tourville TW, Connolly DA, Reed BV: Effects of sensory-level high-volt pulsed electrical current ondelayed-onset muscle soreness. J Sports Sci. 2006, 24: 941-949. 10.1080/02640410500357226.CrossRefPubMed
10.
go back to reference Pizza FX, McLoughlin TJ, McGregor SJ, Calomeni EP, Gunning WT: Neutrophils injure cultured skeletal myotubes. Am J Physiol Cell Physiol. 2001, 281: C335-41.PubMed Pizza FX, McLoughlin TJ, McGregor SJ, Calomeni EP, Gunning WT: Neutrophils injure cultured skeletal myotubes. Am J Physiol Cell Physiol. 2001, 281: C335-41.PubMed
11.
go back to reference Gorski T, Cadore EL, Pinto SS, da Silva EM, Correa CS, Beltrami FG, Kruel LF: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in triathletes: Prevalence, level of awareness, and reasons for use. Br J Sports Med. 2009, doi:10.1136/bjsm.2009.062166. Gorski T, Cadore EL, Pinto SS, da Silva EM, Correa CS, Beltrami FG, Kruel LF: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in triathletes: Prevalence, level of awareness, and reasons for use. Br J Sports Med. 2009, doi:10.1136/bjsm.2009.062166.
12.
go back to reference Howatson G, van Someren KA: The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008, 38: 483-503. 10.2165/00007256-200838060-00004.CrossRefPubMed Howatson G, van Someren KA: The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008, 38: 483-503. 10.2165/00007256-200838060-00004.CrossRefPubMed
13.
go back to reference Seeram NP, Bourquin LD, Nair MG: Degradation products of cyanidin glycosides from tart cherries and their bioactivities. J Agric Food Chem. 2001, 49: 4924-4929. 10.1021/jf0107508.CrossRefPubMed Seeram NP, Bourquin LD, Nair MG: Degradation products of cyanidin glycosides from tart cherries and their bioactivities. J Agric Food Chem. 2001, 49: 4924-4929. 10.1021/jf0107508.CrossRefPubMed
14.
go back to reference Wang H, Nair MG, Strasburg GM, Chang YC, Booren AM, Gray JI, DeWitt DL: Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod. 1999, 62: 802-10.1021/np990184z.CrossRefPubMed Wang H, Nair MG, Strasburg GM, Chang YC, Booren AM, Gray JI, DeWitt DL: Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod. 1999, 62: 802-10.1021/np990184z.CrossRefPubMed
15.
go back to reference Connolly DA, McHugh MP, Padilla-Zakour OI, Carlson L, Sayers SP: Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. Br J Sports Med. 2006, 40: 679-83. 10.1136/bjsm.2005.025429. discussion 683.PubMedCentralCrossRefPubMed Connolly DA, McHugh MP, Padilla-Zakour OI, Carlson L, Sayers SP: Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. Br J Sports Med. 2006, 40: 679-83. 10.1136/bjsm.2005.025429. discussion 683.PubMedCentralCrossRefPubMed
16.
go back to reference Jacob RA, Spinozzi GM, Simon VA, Kelley DS, Prior RL, Hess-Pierce B, Kader AA: Consumption of cherries lowers plasma urate in healthy women. J Nutr. 2003, 133: 1826-1829.PubMed Jacob RA, Spinozzi GM, Simon VA, Kelley DS, Prior RL, Hess-Pierce B, Kader AA: Consumption of cherries lowers plasma urate in healthy women. J Nutr. 2003, 133: 1826-1829.PubMed
17.
go back to reference Connolly DA, Sayers SP, McHugh MP: Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res. 2003, 17: 197-208. 10.1519/1533-4287(2003)017<0197:TAPODO>2.0.CO;2.PubMed Connolly DA, Sayers SP, McHugh MP: Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res. 2003, 17: 197-208. 10.1519/1533-4287(2003)017<0197:TAPODO>2.0.CO;2.PubMed
18.
go back to reference Singleton VJ, Rossi JA: Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965, 16: 144-158. Singleton VJ, Rossi JA: Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965, 16: 144-158.
19.
go back to reference Giusti MM, Wrolstad RE: Characterization and measurement with UV-visible spectroscopy. Current Protocols in Food Analytical Chemistry. Edited by: Wrolstad RE. 2001, New York, John Wiley & Sons, Inc, F1.2.1-13. Giusti MM, Wrolstad RE: Characterization and measurement with UV-visible spectroscopy. Current Protocols in Food Analytical Chemistry. Edited by: Wrolstad RE. 2001, New York, John Wiley & Sons, Inc, F1.2.1-13.
20.
go back to reference Bijur PE, Silver W, Gallagher EJ: Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med. 2001, 8: 1153-1157. 10.1111/j.1553-2712.2001.tb01132.x.CrossRefPubMed Bijur PE, Silver W, Gallagher EJ: Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med. 2001, 8: 1153-1157. 10.1111/j.1553-2712.2001.tb01132.x.CrossRefPubMed
21.
go back to reference Todd KH, Funk KG, Funk JP, Bonacci R: Clinical significance of reported changes in pain severity. Ann Emerg Med. 1996, 27: 485-489. 10.1016/S0196-0644(96)70238-X.CrossRefPubMed Todd KH, Funk KG, Funk JP, Bonacci R: Clinical significance of reported changes in pain severity. Ann Emerg Med. 1996, 27: 485-489. 10.1016/S0196-0644(96)70238-X.CrossRefPubMed
22.
go back to reference Clarkson PM, Hubal MJ: Exercise-induced muscle damage in humans. Am J Phys Med Rehabil. 2002, 81: S52-69. 10.1097/00002060-200211001-00007.CrossRefPubMed Clarkson PM, Hubal MJ: Exercise-induced muscle damage in humans. Am J Phys Med Rehabil. 2002, 81: S52-69. 10.1097/00002060-200211001-00007.CrossRefPubMed
23.
go back to reference Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Ichikawa H, Yoshida N, Yoshikawa T: Oxidative stress and delayed-onset muscle damage after exercise. Free Radic Biol Med. 2004, 37: 480-487. 10.1016/j.freeradbiomed.2004.05.008.CrossRefPubMed Aoi W, Naito Y, Takanami Y, Kawai Y, Sakuma K, Ichikawa H, Yoshida N, Yoshikawa T: Oxidative stress and delayed-onset muscle damage after exercise. Free Radic Biol Med. 2004, 37: 480-487. 10.1016/j.freeradbiomed.2004.05.008.CrossRefPubMed
24.
go back to reference Miles MP, Andring JM, Pearson SD, Gordon LK, Kasper C, Depner CM, Kidd JR: Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables. J Appl Physiol. 2008, 104: 451-458. 10.1152/japplphysiol.00572.2007.CrossRefPubMed Miles MP, Andring JM, Pearson SD, Gordon LK, Kasper C, Depner CM, Kidd JR: Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables. J Appl Physiol. 2008, 104: 451-458. 10.1152/japplphysiol.00572.2007.CrossRefPubMed
25.
go back to reference Hirose L, Nosaka K, Newton M, Laveder A, Kano M, Peake J, Suzuki K: Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exerc Immunol Rev. 2004, 10: 75-90.PubMed Hirose L, Nosaka K, Newton M, Laveder A, Kano M, Peake J, Suzuki K: Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exerc Immunol Rev. 2004, 10: 75-90.PubMed
26.
go back to reference Kelley DS, Rasooly R, Jacob RA, Kader AA, Mackey BE: Consumption of bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J Nutr. 2006, 136: 981-986.PubMed Kelley DS, Rasooly R, Jacob RA, Kader AA, Mackey BE: Consumption of bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J Nutr. 2006, 136: 981-986.PubMed
27.
go back to reference Howatson G, McHugh MP, Hill JA, Brouner J, Jewell AP, van Someren KA, Shave RE, Howatson SA: Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports. 2009, doi: 10.1111/j.1600-0838.2009.01005.x. Howatson G, McHugh MP, Hill JA, Brouner J, Jewell AP, van Someren KA, Shave RE, Howatson SA: Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports. 2009, doi: 10.1111/j.1600-0838.2009.01005.x.
28.
go back to reference Gallagher EJ, Liebman M, Bijur PE: Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001, 38: 633-638. 10.1067/mem.2001.118863.CrossRefPubMed Gallagher EJ, Liebman M, Bijur PE: Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001, 38: 633-638. 10.1067/mem.2001.118863.CrossRefPubMed
Metadata
Title
Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial
Authors
Kerry S Kuehl
Erica T Perrier
Diane L Elliot
James C Chesnutt
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1550-2783-7-17

Other articles of this Issue 1/2010

Journal of the International Society of Sports Nutrition 1/2010 Go to the issue