Skip to main content
Top
Published in: Journal of the International Society of Sports Nutrition 1/2007

Open Access 01-12-2007 | Commentary

International Society of Sports Nutrition position stand: protein and exercise

Authors: Bill Campbell, Richard B Kreider, Tim Ziegenfuss, Paul La Bounty, Mike Roberts, Darren Burke, Jamie Landis, Hector Lopez, Jose Antonio

Published in: Journal of the International Society of Sports Nutrition | Issue 1/2007

Login to get access

Abstract

Position Statement

The following seven points related to the intake of protein for healthy, exercising individuals constitute the position stand of the Society. They have been approved by the Research Committee of the Society. 1) Vast research supports the contention that individuals engaged in regular exercise training require more dietary protein than sedentary individuals. 2) Protein intakes of 1.4 – 2.0 g/kg/day for physically active individuals is not only safe, but may improve the training adaptations to exercise training. 3) When part of a balanced, nutrient-dense diet, protein intakes at this level are not detrimental to kidney function or bone metabolism in healthy, active persons. 4) While it is possible for physically active individuals to obtain their daily protein requirements through a varied, regular diet, supplemental protein in various forms are a practical way of ensuring adequate and quality protein intake for athletes. 5) Different types and quality of protein can affect amino acid bioavailability following protein supplementation. The superiority of one protein type over another in terms of optimizing recovery and/or training adaptations remains to be convincingly demonstrated. 6) Appropriately timed protein intake is an important component of an overall exercise training program, essential for proper recovery, immune function, and the growth and maintenance of lean body mass. 7) Under certain circumstances, specific amino acid supplements, such as branched-chain amino acids (BCAA's), may improve exercise performance and recovery from exercise.
Literature
1.
go back to reference Institute of Medicine of the National Academies: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). 2002, Washington, DC , National Academies Press Institute of Medicine of the National Academies: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). 2002, Washington, DC , National Academies Press
2.
go back to reference Lemon PW: Beyond the zone: protein needs of active individuals. J Am Coll Nutr. 2000, 19 (5 Suppl): 513S-521S.PubMed Lemon PW: Beyond the zone: protein needs of active individuals. J Am Coll Nutr. 2000, 19 (5 Suppl): 513S-521S.PubMed
3.
go back to reference Joint Position Statement: nutrition and athletic performance. American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Med Sci Sports Exerc. 2000, 32 (12): 2130-2145. 10.1097/00005768-200012000-00025. Joint Position Statement: nutrition and athletic performance. American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Med Sci Sports Exerc. 2000, 32 (12): 2130-2145. 10.1097/00005768-200012000-00025.
4.
go back to reference Tarnopolsky M: Protein requirements for endurance athletes. Nutrition. 2004, 20 (7-8): 662-668. 10.1016/j.nut.2004.04.008.PubMed Tarnopolsky M: Protein requirements for endurance athletes. Nutrition. 2004, 20 (7-8): 662-668. 10.1016/j.nut.2004.04.008.PubMed
5.
go back to reference Rand WM, Pellett PL, Young VR: Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am J Clin Nutr. 2003, 77 (1): 109-127.PubMed Rand WM, Pellett PL, Young VR: Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am J Clin Nutr. 2003, 77 (1): 109-127.PubMed
6.
go back to reference Forslund AH, El-Khoury AE, Olsson RM, Sjodin AM, Hambraeus L, Young VR: Effect of protein intake and physical activity on 24-h pattern and rate of macronutrient utilization. Am J Physiol. 1999, 276 (5 Pt 1): E964-76.PubMed Forslund AH, El-Khoury AE, Olsson RM, Sjodin AM, Hambraeus L, Young VR: Effect of protein intake and physical activity on 24-h pattern and rate of macronutrient utilization. Am J Physiol. 1999, 276 (5 Pt 1): E964-76.PubMed
7.
go back to reference Meredith CN, Zackin MJ, Frontera WR, Evans WJ: Dietary protein requirements and body protein metabolism in endurance-trained men. J Appl Physiol. 1989, 66 (6): 2850-2856.PubMed Meredith CN, Zackin MJ, Frontera WR, Evans WJ: Dietary protein requirements and body protein metabolism in endurance-trained men. J Appl Physiol. 1989, 66 (6): 2850-2856.PubMed
8.
go back to reference Phillips SM, Atkinson SA, Tarnopolsky MA, MacDougall JD: Gender differences in leucine kinetics and nitrogen balance in endurance athletes. J Appl Physiol. 1993, 75 (5): 2134-2141.PubMed Phillips SM, Atkinson SA, Tarnopolsky MA, MacDougall JD: Gender differences in leucine kinetics and nitrogen balance in endurance athletes. J Appl Physiol. 1993, 75 (5): 2134-2141.PubMed
9.
go back to reference Lamont LS, Patel DG, Kalhan SC: Leucine kinetics in endurance-trained humans. J Appl Physiol. 1990, 69 (1): 1-6.PubMed Lamont LS, Patel DG, Kalhan SC: Leucine kinetics in endurance-trained humans. J Appl Physiol. 1990, 69 (1): 1-6.PubMed
10.
go back to reference Friedman JE, Lemon PW: Effect of chronic endurance exercise on retention of dietary protein. Int J Sports Med. 1989, 10 (2): 118-123.PubMed Friedman JE, Lemon PW: Effect of chronic endurance exercise on retention of dietary protein. Int J Sports Med. 1989, 10 (2): 118-123.PubMed
11.
go back to reference Tarnopolsky MA, Atkinson SA, MacDougall JD, Chesley A, Phillips S, Schwarcz HP: Evaluation of protein requirements for trained strength athletes. J Appl Physiol. 1992, 73 (5): 1986-1995.PubMed Tarnopolsky MA, Atkinson SA, MacDougall JD, Chesley A, Phillips S, Schwarcz HP: Evaluation of protein requirements for trained strength athletes. J Appl Physiol. 1992, 73 (5): 1986-1995.PubMed
12.
go back to reference Lemon PW, Tarnopolsky MA, MacDougall JD, Atkinson SA: Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol. 1992, 73 (2): 767-775.PubMed Lemon PW, Tarnopolsky MA, MacDougall JD, Atkinson SA: Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol. 1992, 73 (2): 767-775.PubMed
13.
go back to reference Lemon PW: Protein and amino acid needs of the strength athlete. Int J Sport Nutr. 1991, 1 (2): 127-145.PubMed Lemon PW: Protein and amino acid needs of the strength athlete. Int J Sport Nutr. 1991, 1 (2): 127-145.PubMed
14.
go back to reference Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN: ISSN Exercise and Sport Nutrition Review: Research and Recommendations. Journal of the International Society of Sports Nutrition. 2004, 1 (1): 1-44.PubMedCentral Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN: ISSN Exercise and Sport Nutrition Review: Research and Recommendations. Journal of the International Society of Sports Nutrition. 2004, 1 (1): 1-44.PubMedCentral
15.
go back to reference Gaine PC, Pikosky MA, Martin WF, Bolster DR, Maresh CM, Rodriguez NR: Level of dietary protein impacts whole body protein turnover in trained males at rest. Metabolism. 2006, 55 (4): 501-507. 10.1016/j.metabol.2005.10.012.PubMed Gaine PC, Pikosky MA, Martin WF, Bolster DR, Maresh CM, Rodriguez NR: Level of dietary protein impacts whole body protein turnover in trained males at rest. Metabolism. 2006, 55 (4): 501-507. 10.1016/j.metabol.2005.10.012.PubMed
16.
go back to reference Antonio J, Stout JR: Sports Supplements. 2001, Philadelphia, PA , Lippincott Williams & Wilkins Antonio J, Stout JR: Sports Supplements. 2001, Philadelphia, PA , Lippincott Williams & Wilkins
17.
go back to reference Rennie MJ, Tipton KD: Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr. 2000, 20: 457-483. 10.1146/annurev.nutr.20.1.457.PubMed Rennie MJ, Tipton KD: Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr. 2000, 20: 457-483. 10.1146/annurev.nutr.20.1.457.PubMed
18.
go back to reference Lemon PW: Protein requirements of soccer. J Sports Sci. 1994, 12 Spec No: S17-22.PubMed Lemon PW: Protein requirements of soccer. J Sports Sci. 1994, 12 Spec No: S17-22.PubMed
19.
go back to reference Metges CC, Barth CA: Metabolic consequences of a high dietary-protein intake in adulthood: assessment of the available evidence. J Nutr. 2000, 130 (4): 886-889.PubMed Metges CC, Barth CA: Metabolic consequences of a high dietary-protein intake in adulthood: assessment of the available evidence. J Nutr. 2000, 130 (4): 886-889.PubMed
20.
go back to reference Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982, 307 (11): 652-659.PubMed Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982, 307 (11): 652-659.PubMed
21.
go back to reference Martin WF, Armstrong LE, Rodriguez NR: Dietary protein intake and renal function. Nutr Metab (Lond). 2005, 2: 25-10.1186/1743-7075-2-25. Martin WF, Armstrong LE, Rodriguez NR: Dietary protein intake and renal function. Nutr Metab (Lond). 2005, 2: 25-10.1186/1743-7075-2-25.
22.
go back to reference Knight EL, Stampfer MJ, Hankinson SE, Spiegelman D, Curhan GC: The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency. Ann Intern Med. 2003, 138 (6): 460-467.PubMed Knight EL, Stampfer MJ, Hankinson SE, Spiegelman D, Curhan GC: The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency. Ann Intern Med. 2003, 138 (6): 460-467.PubMed
23.
go back to reference Bedford JL, Barr SI: Diets and selected lifestyle practices of self-defined adult vegetarians from a population-based sample suggest they are more 'health conscious'. Int J Behav Nutr Phys Act. 2005, 2 (1): 4-10.1186/1479-5868-2-4.PubMedCentralPubMed Bedford JL, Barr SI: Diets and selected lifestyle practices of self-defined adult vegetarians from a population-based sample suggest they are more 'health conscious'. Int J Behav Nutr Phys Act. 2005, 2 (1): 4-10.1186/1479-5868-2-4.PubMedCentralPubMed
24.
go back to reference Blum M, Averbuch M, Wolman Y, Aviram A: Protein intake and kidney function in humans: its effect on 'normal aging'. Arch Intern Med. 1989, 149 (1): 211-212. 10.1001/archinte.149.1.211.PubMed Blum M, Averbuch M, Wolman Y, Aviram A: Protein intake and kidney function in humans: its effect on 'normal aging'. Arch Intern Med. 1989, 149 (1): 211-212. 10.1001/archinte.149.1.211.PubMed
25.
go back to reference Pecoits-Filho R: Dietary protein intake and kidney disease in Western diet. Contrib Nephrol. 2007, 155: 102-112.PubMed Pecoits-Filho R: Dietary protein intake and kidney disease in Western diet. Contrib Nephrol. 2007, 155: 102-112.PubMed
26.
go back to reference Lentine K, Wrone EM: New insights into protein intake and progression of renal disease. Curr Opin Nephrol Hypertens. 2004, 13 (3): 333-336. 10.1097/00041552-200405000-00011.PubMed Lentine K, Wrone EM: New insights into protein intake and progression of renal disease. Curr Opin Nephrol Hypertens. 2004, 13 (3): 333-336. 10.1097/00041552-200405000-00011.PubMed
27.
go back to reference Ginty F: Dietary protein and bone health. Proc Nutr Soc. 2003, 62 (4): 867-876. 10.1079/PNS2003307.PubMed Ginty F: Dietary protein and bone health. Proc Nutr Soc. 2003, 62 (4): 867-876. 10.1079/PNS2003307.PubMed
28.
go back to reference Dawson-Hughes B, Harris SS, Rasmussen H, Song L, Dallal GE: Effect of dietary protein supplements on calcium excretion in healthy older men and women. J Clin Endocrinol Metab. 2004, 89 (3): 1169-1173. 10.1210/jc.2003-031466.PubMed Dawson-Hughes B, Harris SS, Rasmussen H, Song L, Dallal GE: Effect of dietary protein supplements on calcium excretion in healthy older men and women. J Clin Endocrinol Metab. 2004, 89 (3): 1169-1173. 10.1210/jc.2003-031466.PubMed
29.
go back to reference Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KL: The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab. 2005, 90 (1): 26-31. 10.1210/jc.2004-0179.PubMed Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KL: The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab. 2005, 90 (1): 26-31. 10.1210/jc.2004-0179.PubMed
30.
go back to reference Vicente-Rodriguez G: How does exercise affect bone development during growth?. Sports Med. 2006, 36 (7): 561-569. 10.2165/00007256-200636070-00002.PubMed Vicente-Rodriguez G: How does exercise affect bone development during growth?. Sports Med. 2006, 36 (7): 561-569. 10.2165/00007256-200636070-00002.PubMed
31.
go back to reference Vicente-Rodriguez G, Ara I, Perez-Gomez J, Dorado C, Calbet JA: Muscular development and physical activity as major determinants of femoral bone mass acquisition during growth. Br J Sports Med. 2005, 39 (9): 611-616. 10.1136/bjsm.2004.014431.PubMedCentralPubMed Vicente-Rodriguez G, Ara I, Perez-Gomez J, Dorado C, Calbet JA: Muscular development and physical activity as major determinants of femoral bone mass acquisition during growth. Br J Sports Med. 2005, 39 (9): 611-616. 10.1136/bjsm.2004.014431.PubMedCentralPubMed
32.
go back to reference Tipton KD, Wolfe RR: Protein and amino acids for athletes. J Sports Sci. 2004, 22 (1): 65-79. 10.1080/0264041031000140554.PubMed Tipton KD, Wolfe RR: Protein and amino acids for athletes. J Sports Sci. 2004, 22 (1): 65-79. 10.1080/0264041031000140554.PubMed
33.
go back to reference Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RR: Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise. Med Sci Sports Exerc. 2004, 36 (12): 2073-2081. 10.1249/01.MSS.0000147582.99810.C5.PubMed Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RR: Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise. Med Sci Sports Exerc. 2004, 36 (12): 2073-2081. 10.1249/01.MSS.0000147582.99810.C5.PubMed
34.
go back to reference Darragh AJ, Hodgkinson SM: Quantifying the digestibility of dietary protein. J Nutr. 2000, 130 (7): 1850S-6S.PubMed Darragh AJ, Hodgkinson SM: Quantifying the digestibility of dietary protein. J Nutr. 2000, 130 (7): 1850S-6S.PubMed
35.
go back to reference Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrere B: Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A. 1997, 94 (26): 14930-14935. 10.1073/pnas.94.26.14930.PubMedCentralPubMed Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrere B: Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A. 1997, 94 (26): 14930-14935. 10.1073/pnas.94.26.14930.PubMedCentralPubMed
36.
go back to reference Bos C, Metges CC, Gaudichon C, Petzke KJ, Pueyo ME, Morens C, Everwand J, Benamouzig R, Tome D: Postprandial kinetics of dietary amino acids are the main determinant of their metabolism after soy or milk protein ingestion in humans. J Nutr. 2003, 133 (5): 1308-1315.PubMed Bos C, Metges CC, Gaudichon C, Petzke KJ, Pueyo ME, Morens C, Everwand J, Benamouzig R, Tome D: Postprandial kinetics of dietary amino acids are the main determinant of their metabolism after soy or milk protein ingestion in humans. J Nutr. 2003, 133 (5): 1308-1315.PubMed
37.
go back to reference Dangin M, Boirie Y, Garcia-Rodenas C, Gachon P, Fauquant J, Callier P, Ballevre O, Beaufrere B: The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol Endocrinol Metab. 2001, 280 (2): E340-8.PubMed Dangin M, Boirie Y, Garcia-Rodenas C, Gachon P, Fauquant J, Callier P, Ballevre O, Beaufrere B: The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol Endocrinol Metab. 2001, 280 (2): E340-8.PubMed
38.
go back to reference Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballevre O, Beaufrere B: The rate of protein digestion affects protein gain differently during aging in humans. J Physiol. 2003, 549 (Pt 2): 635-644. 10.1113/jphysiol.2002.036897.PubMedCentralPubMed Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballevre O, Beaufrere B: The rate of protein digestion affects protein gain differently during aging in humans. J Physiol. 2003, 549 (Pt 2): 635-644. 10.1113/jphysiol.2002.036897.PubMedCentralPubMed
39.
go back to reference Rodriguez NR, Vislocky LM, Gaine PC: Dietary protein, endurance exercise, and human skeletal-muscle protein turnover. Curr Opin Clin Nutr Metab Care. 2007, 10 (1): 40-45.PubMed Rodriguez NR, Vislocky LM, Gaine PC: Dietary protein, endurance exercise, and human skeletal-muscle protein turnover. Curr Opin Clin Nutr Metab Care. 2007, 10 (1): 40-45.PubMed
40.
go back to reference Phillips SM, Parise G, Roy BD, Tipton KD, Wolfe RR, Tamopolsky MA: Resistance-training-induced adaptations in skeletal muscle protein turnover in the fed state. Can J Physiol Pharmacol. 2002, 80 (11): 1045-1053. 10.1139/y02-134.PubMed Phillips SM, Parise G, Roy BD, Tipton KD, Wolfe RR, Tamopolsky MA: Resistance-training-induced adaptations in skeletal muscle protein turnover in the fed state. Can J Physiol Pharmacol. 2002, 80 (11): 1045-1053. 10.1139/y02-134.PubMed
41.
go back to reference Rennie MJ, Bohe J, Smith K, Wackerhage H, Greenhaff P: Branched-chain amino acids as fuels and anabolic signals in human muscle. J Nutr. 2006, 136 (1 Suppl): 264S-8S.PubMed Rennie MJ, Bohe J, Smith K, Wackerhage H, Greenhaff P: Branched-chain amino acids as fuels and anabolic signals in human muscle. J Nutr. 2006, 136 (1 Suppl): 264S-8S.PubMed
42.
go back to reference Yang Y, Jemiolo B, Trappe S: Proteolytic mRNA expression in response to acute resistance exercise in human single skeletal muscle fibers. J Appl Physiol. 2006, 101 (5): 1442-1450. 10.1152/japplphysiol.00438.2006.PubMed Yang Y, Jemiolo B, Trappe S: Proteolytic mRNA expression in response to acute resistance exercise in human single skeletal muscle fibers. J Appl Physiol. 2006, 101 (5): 1442-1450. 10.1152/japplphysiol.00438.2006.PubMed
43.
go back to reference Biolo G, Maggi SP, Williams BD, Tipton KD, Wolfe RR: Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol. 1995, 268 (3 Pt 1): E514-20.PubMed Biolo G, Maggi SP, Williams BD, Tipton KD, Wolfe RR: Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol. 1995, 268 (3 Pt 1): E514-20.PubMed
44.
go back to reference Biolo G, Tipton KD, Klein S, Wolfe RR: An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol. 1997, 273 (1 Pt 1): E122-9.PubMed Biolo G, Tipton KD, Klein S, Wolfe RR: An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol. 1997, 273 (1 Pt 1): E122-9.PubMed
45.
go back to reference Willoughby DS, Stout JR, Wilborn CD: Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength. Amino Acids. 2007, 32 (4): 467-477. 10.1007/s00726-006-0398-7.PubMed Willoughby DS, Stout JR, Wilborn CD: Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength. Amino Acids. 2007, 32 (4): 467-477. 10.1007/s00726-006-0398-7.PubMed
46.
go back to reference Cribb PJ, Williams AD, Stathis CG, Carey MF, Hayes A: Effects of whey isolate, creatine, and resistance training on muscle hypertrophy. Med Sci Sports Exerc. 2007, 39 (2): 298-307. 10.1249/01.mss.0000247002.32589.ef.PubMed Cribb PJ, Williams AD, Stathis CG, Carey MF, Hayes A: Effects of whey isolate, creatine, and resistance training on muscle hypertrophy. Med Sci Sports Exerc. 2007, 39 (2): 298-307. 10.1249/01.mss.0000247002.32589.ef.PubMed
47.
go back to reference Tipton KD, Borsheim E, Wolf SE, Sanford AP, Wolfe RR: Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion. Am J Physiol Endocrinol Metab. 2003, 284 (1): E76-89.PubMed Tipton KD, Borsheim E, Wolf SE, Sanford AP, Wolfe RR: Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion. Am J Physiol Endocrinol Metab. 2003, 284 (1): E76-89.PubMed
48.
go back to reference Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer M: Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. J Physiol. 2001, 535 (Pt 1): 301-311. 10.1111/j.1469-7793.2001.00301.x.PubMedCentralPubMed Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer M: Timing of postexercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. J Physiol. 2001, 535 (Pt 1): 301-311. 10.1111/j.1469-7793.2001.00301.x.PubMedCentralPubMed
49.
go back to reference Tipton KD, Ferrando AA, Phillips SM, Doyle D, Wolfe RR: Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol. 1999, 276 (4 Pt 1): E628-34.PubMed Tipton KD, Ferrando AA, Phillips SM, Doyle D, Wolfe RR: Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol. 1999, 276 (4 Pt 1): E628-34.PubMed
50.
go back to reference Flakoll PJ, Judy T, Flinn K, Carr C, Flinn S: Postexercise protein supplementation improves health and muscle soreness during basic military training in Marine recruits. J Appl Physiol. 2004, 96 (3): 951-956. 10.1152/japplphysiol.00811.2003.PubMed Flakoll PJ, Judy T, Flinn K, Carr C, Flinn S: Postexercise protein supplementation improves health and muscle soreness during basic military training in Marine recruits. J Appl Physiol. 2004, 96 (3): 951-956. 10.1152/japplphysiol.00811.2003.PubMed
51.
go back to reference Bounous G, Batist G, Gold P: Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin Invest Med. 1989, 12 (3): 154-161.PubMed Bounous G, Batist G, Gold P: Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin Invest Med. 1989, 12 (3): 154-161.PubMed
52.
go back to reference Bounous G, Kongshavn PA, Gold P: The immunoenhancing property of dietary whey protein concentrate. Clin Invest Med. 1988, 11 (4): 271-278.PubMed Bounous G, Kongshavn PA, Gold P: The immunoenhancing property of dietary whey protein concentrate. Clin Invest Med. 1988, 11 (4): 271-278.PubMed
53.
go back to reference Mero A: Leucine supplementation and intensive training. Sports Med. 1999, 27 (6): 347-358. 10.2165/00007256-199927060-00001.PubMed Mero A: Leucine supplementation and intensive training. Sports Med. 1999, 27 (6): 347-358. 10.2165/00007256-199927060-00001.PubMed
54.
go back to reference Kimball SR, Jefferson LS: Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr. 2006, 136 (1 Suppl): 227S-31S.PubMed Kimball SR, Jefferson LS: Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr. 2006, 136 (1 Suppl): 227S-31S.PubMed
55.
go back to reference Louard RJ, Barrett EJ, Gelfand RA: Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man. Clin Sci (Lond). 1990, 79 (5): 457-466. Louard RJ, Barrett EJ, Gelfand RA: Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man. Clin Sci (Lond). 1990, 79 (5): 457-466.
56.
go back to reference Blomstrand E, Eliasson J, Karlsson HK, Kohnke R: Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. 2006, 136 (1 Suppl): 269S-73S.PubMed Blomstrand E, Eliasson J, Karlsson HK, Kohnke R: Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. 2006, 136 (1 Suppl): 269S-73S.PubMed
57.
go back to reference Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ: Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab. 2005, 288 (4): E645-53. 10.1152/ajpendo.00413.2004.PubMed Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ: Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab. 2005, 288 (4): E645-53. 10.1152/ajpendo.00413.2004.PubMed
58.
go back to reference Blomstrand E, Newsholme EA: Effect of branched-chain amino acid supplementation on the exercise-induced change in aromatic amino acid concentration in human muscle. Acta Physiol Scand. 1992, 146 (3): 293-298.PubMed Blomstrand E, Newsholme EA: Effect of branched-chain amino acid supplementation on the exercise-induced change in aromatic amino acid concentration in human muscle. Acta Physiol Scand. 1992, 146 (3): 293-298.PubMed
59.
go back to reference Blomstrand E, Ek S, Newsholme EA: Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition. 1996, 12 (7-8): 485-490. 10.1016/S0899-9007(96)91723-2.PubMed Blomstrand E, Ek S, Newsholme EA: Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition. 1996, 12 (7-8): 485-490. 10.1016/S0899-9007(96)91723-2.PubMed
60.
go back to reference Blomstrand E, Hassmen P, Ekblom B, Newsholme EA: Administration of branched-chain amino acids during sustained exercise--effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol Occup Physiol. 1991, 63 (2): 83-88. 10.1007/BF00235174.PubMed Blomstrand E, Hassmen P, Ekblom B, Newsholme EA: Administration of branched-chain amino acids during sustained exercise--effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol Occup Physiol. 1991, 63 (2): 83-88. 10.1007/BF00235174.PubMed
61.
go back to reference Blomstrand E: A role for branched-chain amino acids in reducing central fatigue. J Nutr. 2006, 136 (2): 544S-547S.PubMed Blomstrand E: A role for branched-chain amino acids in reducing central fatigue. J Nutr. 2006, 136 (2): 544S-547S.PubMed
62.
go back to reference Newsholme EA, Blomstrand E, Ekblom B: Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids. Br Med Bull. 1992, 48 (3): 477-495.PubMed Newsholme EA, Blomstrand E, Ekblom B: Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids. Br Med Bull. 1992, 48 (3): 477-495.PubMed
63.
go back to reference Pitkanen HT, Oja SS, Rusko H, Nummela A, Komi PV, Saransaari P, Takala T, Mero AA: Leucine supplementation does not enhance acute strength or running performance but affects serum amino acid concentration. Amino Acids. 2003, 25 (1): 85-94.PubMed Pitkanen HT, Oja SS, Rusko H, Nummela A, Komi PV, Saransaari P, Takala T, Mero AA: Leucine supplementation does not enhance acute strength or running performance but affects serum amino acid concentration. Amino Acids. 2003, 25 (1): 85-94.PubMed
64.
go back to reference Shimomura Y, Murakami T, Nakai N, Nagasaki M, Harris RA: Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr. 2004, 134 (6 Suppl): 1583S-1587S.PubMed Shimomura Y, Murakami T, Nakai N, Nagasaki M, Harris RA: Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr. 2004, 134 (6 Suppl): 1583S-1587S.PubMed
Metadata
Title
International Society of Sports Nutrition position stand: protein and exercise
Authors
Bill Campbell
Richard B Kreider
Tim Ziegenfuss
Paul La Bounty
Mike Roberts
Darren Burke
Jamie Landis
Hector Lopez
Jose Antonio
Publication date
01-12-2007
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1550-2783-4-8

Other articles of this Issue 1/2007

Journal of the International Society of Sports Nutrition 1/2007 Go to the issue