Published in:
Open Access
01-11-2013 | Meeting abstract
OR6-004 – MRP8/14 promote MSU-crystal induced inflammation
Authors:
D Holzinger, N Nippe, T Vogl, K Marketon, V Mysore, T Weinhage, N Dalbeth, B Pool, T Merriman, D Baeten, A Ives, N Bagnoud, N Busso, D Foell, S Bas, C Gabay, J Roth
Published in:
Pediatric Rheumatology
|
Special Issue 1/2013
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Excerpt
Monosodium urate (MSU) crystal induced interleukin-1 (IL-1β) secretion is a critical pathogenic factor in the development of gout and serves as therapeutic target in these patients. Nevertheless, without co-stimulation by a pro-IL-1ß inducing factor, e.g. lipopolysaccharides (LPS), MSU alone cannot induce IL-1β secretion in vitro. The endogenous Toll-like receptor 4 (TLR-4) agonists myeloid related protein (MRP) 8 and MRP14 play a significant role in human inflammatory diseases, reflect disease activity and have been shown to be an important pathogenic factor in murine arthritis models. …
