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Open Access 01-11-2013 | Meeting abstract

OR7-005 – Canakinumab in childhood colchicine resistant FMF

Authors: PJ Hashkes, Y Butbul Aviel, S Lubin, L Tseng, E Ben Dayan, T Rachmilewitz, R Brik

Published in: Pediatric Rheumatology | Special Issue 1/2013

Excerpt

Familial Mediterranean Fever (FMF) is the most common hereditary autoinflammatory syndrome affecting >10,000 people in Israel. FMF is caused by mutations in the MEFV gene, which encodes for the pyrin protein that is part of the inflammation complex that activates IL-1β. Evidence from case reports/series and one controlled study supports IL-1 blockage as a potential treatment for FMF. Canakinumab (CAN) is a selective fully human monoclonal anti-IL-1β antibody. …

Title: OR7-005 – Canakinumab in childhood colchicine resistant FMF
Authors: PJ Hashkes
Y Butbul Aviel
S Lubin
L Tseng
E Ben Dayan
T Rachmilewitz
R Brik
Publication date: 01-11-2013
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-11-S1-A106

At a glance: The STEP trials

Springer Medicine

OR7-005 – Canakinumab in childhood colchicine resistant FMF

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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