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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

OR7-001 – By chip pyrin binds the IRF2 promoter

Authors: G Wood, Y Kanno, J Balow Jr, H-W Sun, I Aksentijevich, DL Kastner

Published in: Pediatric Rheumatology | Special Issue 1/2013

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Excerpt

The gene causing familial Mediterranean fever (FMF), MEFV, encodes a protein, pyrin, which is expressed at high levels in granulocytes, monocytes, dendritic cells and in some human myeloid leukemia cell lines, such as THP.1. Studies of pyrin localization show a cell-type dependency. In transfection experiments full-length pyrin is cytoplasmic and associates with the cytoskeleton. However, native pyrin is predominantly nuclear in granulocytes, dendritic cells, and synovial fibroblasts, but it is cytoplasmic in monocytes. Recent studies have implicated pyrin in the regulation of IL-1b and NFΚB activation. …
Metadata
Title
OR7-001 – By chip pyrin binds the IRF2 promoter
Authors
G Wood
Y Kanno
J Balow Jr
H-W Sun
I Aksentijevich
DL Kastner
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A102

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