OR2-001 – The possible role of pyrin on cell migration

Excerpt

MEFV which encodes pyrin, cause familial Mediterranean fever (FMF), the most common auto-inflammatory disease. The pyrin protein appears to be a regulator of inflammation, but its exact role on inflammatory pathways is still controversial. Several pyrin-interacting proteins have been identified, each of which are related to inflammation through regulation of cell death, cytokine secretion, and cytoskeletal signaling. It has been documented that in migrating human monocytes, pyrin protein is dramatically polarized at the leading edge, where it co-localizes with polymerizing actin. Thus, we hypothesized that pyrin may have a key role in cell migration through its interaction with well-known regulators of inflammatory cell migration. …