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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2012

Open Access 01-07-2012 | Poster presentation

Cartilage-protective effects of C-type natriuretic peptide over expression in K/BxN TCR arthritis model

Authors: Hulya Bukulmez, Cynthia F Bartels, Kabita Nanda, Tariq M Haqqi, Jean F Welter

Published in: Pediatric Rheumatology | Special Issue 1/2012

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Excerpt

The c-type natriuretic peptide (CNP) signaling pathway is known as a major contributor to skeletal growth in children. CNP is produced and secreted by both growth plate and joint chondrocytes, and has a paracrine regulatory effect on cartilage tissue. CNP increases matrix production by chondrocytes and promotes their proliferation. In this study, we investigated whether over-expression of CNP in chondrocytes would be protective of joint cartilage degradation during chronic inflammatory arthritis in vivo. …
Metadata
Title
Cartilage-protective effects of C-type natriuretic peptide over expression in K/BxN TCR arthritis model
Authors
Hulya Bukulmez
Cynthia F Bartels
Kabita Nanda
Tariq M Haqqi
Jean F Welter
Publication date
01-07-2012
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2012
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-10-S1-A109

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