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Published in: Journal of Cardiovascular Magnetic Resonance 1/2011

Open Access 01-12-2011 | Review

T2-weighted cardiovascular magnetic resonance in acute cardiac disease

Authors: Ingo Eitel, Matthias G Friedrich

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2011

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Abstract

Cardiovascular magnetic resonance (CMR) using T2-weighted sequences can visualize myocardial edema. When compared to previous protocols, newer pulse sequences with substantially improved image quality have increased its clinical utility. The assessment of myocardial edema provides useful incremental diagnostic and prognostic information in a variety of clinical settings associated with acute myocardial injury. In patients with acute chest pain, T2-weighted CMR is able to identify acute or recent myocardial ischemic injury and has been employed to distinguish acute coronary syndrome (ACS) from non-ACS as well as acute from chronic myocardial infarction.
T2-weighted CMR can also be used to determine the area at risk in reperfused and non-reperfused infarction. When combined with contrast-enhanced imaging, the salvaged area and thus the success of early coronary revascularization can be quantified. Strong evidence for the prognostic value of myocardial salvage has enabled its use as a primary endpoint in clinical trials. The present article reviews the current evidence and clinical applications for T2-weighted CMR in acute cardiac disease and gives an outlook on future developments.
"The principle of all things is water"
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Literature
1.
go back to reference Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, et al: ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010, 55: 2614-2662. 10.1016/j.jacc.2009.11.011.CrossRefPubMed Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, et al: ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010, 55: 2614-2662. 10.1016/j.jacc.2009.11.011.CrossRefPubMed
2.
go back to reference Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE, et al: Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. Eur Heart J. 2004, 25: 1940-1965. 10.1016/j.ehj.2004.06.040.CrossRefPubMed Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE, et al: Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. Eur Heart J. 2004, 25: 1940-1965. 10.1016/j.ehj.2004.06.040.CrossRefPubMed
3.
go back to reference Bruder O, Schneider S, Nothnagel D, Dill T, Hombach V, Schulz-Menger J, et al: EuroCMR (European Cardiovascular Magnetic Resonance) registry: results of the German pilot phase. J Am Coll Cardiol. 2009, 54: 1457-1466. 10.1016/j.jacc.2009.07.003.CrossRefPubMed Bruder O, Schneider S, Nothnagel D, Dill T, Hombach V, Schulz-Menger J, et al: EuroCMR (European Cardiovascular Magnetic Resonance) registry: results of the German pilot phase. J Am Coll Cardiol. 2009, 54: 1457-1466. 10.1016/j.jacc.2009.07.003.CrossRefPubMed
4.
go back to reference Scirica BM: Acute coronary syndrome: emerging tools for diagnosis and risk assessment. J Am Coll Cardiol. 2010, 55: 1403-1415. 10.1016/j.jacc.2009.09.071.CrossRefPubMed Scirica BM: Acute coronary syndrome: emerging tools for diagnosis and risk assessment. J Am Coll Cardiol. 2010, 55: 1403-1415. 10.1016/j.jacc.2009.09.071.CrossRefPubMed
5.
go back to reference Friedrich MG: Tissue characterization of acute myocardial infarction and myocarditis by cardiac magnetic resonance. JACC Cardiovasc Imaging. 2008, 1: 652-662. 10.1016/j.jcmg.2008.07.011.CrossRefPubMed Friedrich MG: Tissue characterization of acute myocardial infarction and myocarditis by cardiac magnetic resonance. JACC Cardiovasc Imaging. 2008, 1: 652-662. 10.1016/j.jcmg.2008.07.011.CrossRefPubMed
6.
go back to reference Friedrich MG: Myocardial edema--a new clinical entity?. Nat Rev Cardiol. 2010, 7: 292-296.PubMed Friedrich MG: Myocardial edema--a new clinical entity?. Nat Rev Cardiol. 2010, 7: 292-296.PubMed
7.
go back to reference Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, et al: Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation. 2004, 109: 2411-2416. 10.1161/01.CIR.0000127428.10985.C6.CrossRefPubMed Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, et al: Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation. 2004, 109: 2411-2416. 10.1161/01.CIR.0000127428.10985.C6.CrossRefPubMed
8.
go back to reference Cury RC, Shash K, Nagurney JT, Rosito G, Shapiro MD, Nomura CH, et al: Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. Circulation. 2008, 118: 837-844. 10.1161/CIRCULATIONAHA.107.740597.CrossRefPubMed Cury RC, Shash K, Nagurney JT, Rosito G, Shapiro MD, Nomura CH, et al: Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. Circulation. 2008, 118: 837-844. 10.1161/CIRCULATIONAHA.107.740597.CrossRefPubMed
9.
go back to reference Raman SV, Simonetti OP, Winner MW, Dickerson JA, He X, Mazzaferri EL, et al: Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome. J Am Coll Cardiol. 2010, 55: 2480-2488. 10.1016/j.jacc.2010.01.047.PubMedCentralCrossRefPubMed Raman SV, Simonetti OP, Winner MW, Dickerson JA, He X, Mazzaferri EL, et al: Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome. J Am Coll Cardiol. 2010, 55: 2480-2488. 10.1016/j.jacc.2010.01.047.PubMedCentralCrossRefPubMed
10.
go back to reference Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt RF, et al: Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation. 2006, 113: 1865-1870. 10.1161/CIRCULATIONAHA.105.576025.CrossRefPubMed Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt RF, et al: Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation. 2006, 113: 1865-1870. 10.1161/CIRCULATIONAHA.105.576025.CrossRefPubMed
11.
go back to reference Tilak GS, Hsu LY, Hoyt RF, Arai AE, Aletras AH: In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction. Invest Radiol. 2008, 43: 7-15. 10.1097/RLI.0b013e3181558822.CrossRefPubMed Tilak GS, Hsu LY, Hoyt RF, Arai AE, Aletras AH: In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction. Invest Radiol. 2008, 43: 7-15. 10.1097/RLI.0b013e3181558822.CrossRefPubMed
12.
go back to reference Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R: The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol. 2008, 51: 1581-1587. 10.1016/j.jacc.2008.01.019.CrossRefPubMed Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R: The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol. 2008, 51: 1581-1587. 10.1016/j.jacc.2008.01.019.CrossRefPubMed
13.
go back to reference Eitel I, Desch S, Fuernau G, Hildebrand L, Gutberlet M, Schuler G, et al: Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J Am Coll Cardiol. 2010, 55: 2470-2479. 10.1016/j.jacc.2010.01.049.CrossRefPubMed Eitel I, Desch S, Fuernau G, Hildebrand L, Gutberlet M, Schuler G, et al: Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J Am Coll Cardiol. 2010, 55: 2470-2479. 10.1016/j.jacc.2010.01.049.CrossRefPubMed
14.
go back to reference Marie PY, Angioi M, Carteaux JP, Escanye JM, Mattei S, Tzvetanov K, et al: Detection and prediction of acute heart transplant rejection with the myocardial T2 determination provided by a black-blood magnetic resonance imaging sequence. J Am Coll Cardiol. 2001, 37: 825-831. 10.1016/S0735-1097(00)01196-7.CrossRefPubMed Marie PY, Angioi M, Carteaux JP, Escanye JM, Mattei S, Tzvetanov K, et al: Detection and prediction of acute heart transplant rejection with the myocardial T2 determination provided by a black-blood magnetic resonance imaging sequence. J Am Coll Cardiol. 2001, 37: 825-831. 10.1016/S0735-1097(00)01196-7.CrossRefPubMed
15.
go back to reference Butler CR, Thompson R, Haykowsky M, Toma M, Paterson I: Cardiovascular magnetic resonance in the diagnosis of acute heart transplant rejection: a review. J Cardiovasc Magn Reson. 2009, 11: 7-10.1186/1532-429X-11-7.PubMedCentralCrossRefPubMed Butler CR, Thompson R, Haykowsky M, Toma M, Paterson I: Cardiovascular magnetic resonance in the diagnosis of acute heart transplant rejection: a review. J Cardiovasc Magn Reson. 2009, 11: 7-10.1186/1532-429X-11-7.PubMedCentralCrossRefPubMed
16.
go back to reference Abdel-Aty H, Boye P, Zagrosek A, Wassmuth R, Kumar A, Messroghli D, et al: Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol. 2005, 45: 1815-1822. 10.1016/j.jacc.2004.11.069.CrossRefPubMed Abdel-Aty H, Boye P, Zagrosek A, Wassmuth R, Kumar A, Messroghli D, et al: Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol. 2005, 45: 1815-1822. 10.1016/j.jacc.2004.11.069.CrossRefPubMed
17.
go back to reference Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, Cooper LT, et al: Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. J Am Coll Cardiol. 2009, 53: 1475-1487. 10.1016/j.jacc.2009.02.007.PubMedCentralCrossRefPubMed Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, Cooper LT, et al: Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. J Am Coll Cardiol. 2009, 53: 1475-1487. 10.1016/j.jacc.2009.02.007.PubMedCentralCrossRefPubMed
18.
go back to reference Abdel-Aty H, Cocker M, Friedrich MG: Myocardial edema is a feature of Tako-Tsubo cardiomyopathy and is related to the severity of systolic dysfunction: Insights from T2-weighted cardiovascular magnetic resonance. Int J Cardiol. 2009, 132: 291-293. 10.1016/j.ijcard.2007.08.102.CrossRefPubMed Abdel-Aty H, Cocker M, Friedrich MG: Myocardial edema is a feature of Tako-Tsubo cardiomyopathy and is related to the severity of systolic dysfunction: Insights from T2-weighted cardiovascular magnetic resonance. Int J Cardiol. 2009, 132: 291-293. 10.1016/j.ijcard.2007.08.102.CrossRefPubMed
19.
go back to reference Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, et al: Differential diagnosis of suspected apical ballooning syndrome using contrast enhanced magnetic resonance imaging. Eur Heart J. 2008, 29: 2651-2659. 10.1093/eurheartj/ehn433.CrossRefPubMed Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, et al: Differential diagnosis of suspected apical ballooning syndrome using contrast enhanced magnetic resonance imaging. Eur Heart J. 2008, 29: 2651-2659. 10.1093/eurheartj/ehn433.CrossRefPubMed
20.
go back to reference Eitel I, Lucke C, Grothoff M, Sareban M, Schuler G, Thiele H, et al: Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic resonance imaging. Eur Radiol. 2010, 20: 422-431. 10.1007/s00330-009-1549-5.CrossRefPubMed Eitel I, Lucke C, Grothoff M, Sareban M, Schuler G, Thiele H, et al: Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic resonance imaging. Eur Radiol. 2010, 20: 422-431. 10.1007/s00330-009-1549-5.CrossRefPubMed
21.
go back to reference Waldenstrom A, Martinussen HJ, Gerdin B, Hallgren R: Accumulation of hyaluronan and tissue edema in experimental myocardial infarction. J Clin Invest. 1991, 88: 1622-1628. 10.1172/JCI115475.PubMedCentralCrossRefPubMed Waldenstrom A, Martinussen HJ, Gerdin B, Hallgren R: Accumulation of hyaluronan and tissue edema in experimental myocardial infarction. J Clin Invest. 1991, 88: 1622-1628. 10.1172/JCI115475.PubMedCentralCrossRefPubMed
22.
go back to reference Abdel-Aty H, Cocker M, Meek C, Tyberg JV, Friedrich MG: Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study. J Am Coll Cardiol. 2009, 53: 1194-1201. 10.1016/j.jacc.2008.10.065.CrossRefPubMed Abdel-Aty H, Cocker M, Meek C, Tyberg JV, Friedrich MG: Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study. J Am Coll Cardiol. 2009, 53: 1194-1201. 10.1016/j.jacc.2008.10.065.CrossRefPubMed
23.
go back to reference Jennings RB, Schaper J, Hill ML, Steenbergen C, Reimer KA: Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure. Circ Res. 1985, 56: 262-278.CrossRefPubMed Jennings RB, Schaper J, Hill ML, Steenbergen C, Reimer KA: Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure. Circ Res. 1985, 56: 262-278.CrossRefPubMed
24.
go back to reference Garcia-Dorado D, Oliveras J: Myocardial oedema: a preventable cause of reperfusion injury?. Cardiovasc Res. 1993, 27: 1555-1563. 10.1093/cvr/27.9.1555.CrossRefPubMed Garcia-Dorado D, Oliveras J: Myocardial oedema: a preventable cause of reperfusion injury?. Cardiovasc Res. 1993, 27: 1555-1563. 10.1093/cvr/27.9.1555.CrossRefPubMed
25.
go back to reference Davis KL, Mehlhorn U, Laine GA, Allen SJ: Myocardial edema, left ventricular function, and pulmonary hypertension. J Appl Physiol. 1995, 78: 132-137. 10.1063/1.360663.CrossRefPubMed Davis KL, Mehlhorn U, Laine GA, Allen SJ: Myocardial edema, left ventricular function, and pulmonary hypertension. J Appl Physiol. 1995, 78: 132-137. 10.1063/1.360663.CrossRefPubMed
26.
go back to reference Laks H, Standeven J, Blair O, Hahn J, Jellinek M, Willman VL: The effects of cardiopulmonary bypass with crystalloid and colloid hemodilution on myocardial extravascular water. J Thorac Cardiovasc Surg. 1977, 73: 129-138.PubMed Laks H, Standeven J, Blair O, Hahn J, Jellinek M, Willman VL: The effects of cardiopulmonary bypass with crystalloid and colloid hemodilution on myocardial extravascular water. J Thorac Cardiovasc Surg. 1977, 73: 129-138.PubMed
27.
go back to reference Mehlhorn U, Davis KL, Burke EJ, Adams D, Laine GA, Allen SJ: Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial lymphatic function. Am J Physiol. 1995, 268: H178-H183.PubMed Mehlhorn U, Davis KL, Burke EJ, Adams D, Laine GA, Allen SJ: Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial lymphatic function. Am J Physiol. 1995, 268: H178-H183.PubMed
28.
go back to reference Hirleman E, Larson DF: Cardiopulmonary bypass and edema: physiology and pathophysiology. Perfusion. 2008, 23: 311-322. 10.1177/0267659109105079.CrossRefPubMed Hirleman E, Larson DF: Cardiopulmonary bypass and edema: physiology and pathophysiology. Perfusion. 2008, 23: 311-322. 10.1177/0267659109105079.CrossRefPubMed
29.
go back to reference Sasaguri S, Sunamori M, Saito K, Suzuki A: Early change of myocardial water during acute cardiac allograft rejection. Jpn Circ J. 1986, 50: 1113-1119.CrossRefPubMed Sasaguri S, Sunamori M, Saito K, Suzuki A: Early change of myocardial water during acute cardiac allograft rejection. Jpn Circ J. 1986, 50: 1113-1119.CrossRefPubMed
30.
go back to reference Pogatsa G, Dubecz E, Gabor G: The role of myocardial edema in the left ventricular diastolic stiffness. Basic Res Cardiol. 1976, 71: 263-269. 10.1007/BF01906451.CrossRefPubMed Pogatsa G, Dubecz E, Gabor G: The role of myocardial edema in the left ventricular diastolic stiffness. Basic Res Cardiol. 1976, 71: 263-269. 10.1007/BF01906451.CrossRefPubMed
31.
go back to reference Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA: Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function. Cardiovasc Res. 2010, 87: 331-229. 10.1093/cvr/cvq145.PubMedCentralCrossRefPubMed Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA: Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function. Cardiovasc Res. 2010, 87: 331-229. 10.1093/cvr/cvq145.PubMedCentralCrossRefPubMed
32.
go back to reference Laine GA, Granger HJ: Microvascular, interstitial, and lymphatic interactions in normal heart. Am J Physiol. 1985, 249: H834-H842.PubMed Laine GA, Granger HJ: Microvascular, interstitial, and lymphatic interactions in normal heart. Am J Physiol. 1985, 249: H834-H842.PubMed
33.
go back to reference DiBona DR, Powell WJ: Quantitative correlation between cell swelling and necrosis in myocardial ischemia in dogs. Circ Res. 1980, 47: 653-665.CrossRefPubMed DiBona DR, Powell WJ: Quantitative correlation between cell swelling and necrosis in myocardial ischemia in dogs. Circ Res. 1980, 47: 653-665.CrossRefPubMed
34.
go back to reference Desai KV, Laine GA, Stewart RH, Cox CS, Quick CM, Allen SJ, et al: Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. Am J Physiol Heart Circ Physiol. 2008, 294: H2428-H2434. 10.1152/ajpheart.00860.2007.CrossRefPubMed Desai KV, Laine GA, Stewart RH, Cox CS, Quick CM, Allen SJ, et al: Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema. Am J Physiol Heart Circ Physiol. 2008, 294: H2428-H2434. 10.1152/ajpheart.00860.2007.CrossRefPubMed
35.
go back to reference Laine GA, Allen SJ: Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Circ Res. 1991, 68: 1713-1721.CrossRefPubMed Laine GA, Allen SJ: Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Circ Res. 1991, 68: 1713-1721.CrossRefPubMed
36.
go back to reference Kuntz ID, Brassfield TS, Law GD, Purcell GV: Hydration of macromolecules. Science. 1969, 163: 1329-1331. 10.1126/science.163.3873.1329.CrossRefPubMed Kuntz ID, Brassfield TS, Law GD, Purcell GV: Hydration of macromolecules. Science. 1969, 163: 1329-1331. 10.1126/science.163.3873.1329.CrossRefPubMed
37.
go back to reference Kloner RA, Rude RE, Carlson N, Maroko PR, DeBoer LW, Braunwald E: Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?. Circulation. 1980, 62: 945-952.CrossRefPubMed Kloner RA, Rude RE, Carlson N, Maroko PR, DeBoer LW, Braunwald E: Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?. Circulation. 1980, 62: 945-952.CrossRefPubMed
38.
go back to reference Wisenberg G, Prato FS, Carroll SE, Turner KL, Marshall T: Serial nuclear magnetic resonance imaging of acute myocardial infarction with and without reperfusion. Am Heart J. 1988, 115: 510-518. 10.1016/0002-8703(88)90798-3.CrossRefPubMed Wisenberg G, Prato FS, Carroll SE, Turner KL, Marshall T: Serial nuclear magnetic resonance imaging of acute myocardial infarction with and without reperfusion. Am Heart J. 1988, 115: 510-518. 10.1016/0002-8703(88)90798-3.CrossRefPubMed
39.
go back to reference Fishbein MC, Maclean D, Maroko PR: The histopathologic evolution of myocardial infarction. Chest. 1978, 73: 843-849. 10.1378/chest.73.6.843.CrossRefPubMed Fishbein MC, Maclean D, Maroko PR: The histopathologic evolution of myocardial infarction. Chest. 1978, 73: 843-849. 10.1378/chest.73.6.843.CrossRefPubMed
40.
go back to reference Schulz-Menger J, Gross M, Messroghli D, Uhlich F, Dietz R, Friedrich MG: Cardiovascular magnetic resonance of acute myocardial infarction at a very early stage. J Am Coll Cardiol. 2003, 42: 513-518. 10.1016/S0735-1097(03)00717-4.CrossRefPubMed Schulz-Menger J, Gross M, Messroghli D, Uhlich F, Dietz R, Friedrich MG: Cardiovascular magnetic resonance of acute myocardial infarction at a very early stage. J Am Coll Cardiol. 2003, 42: 513-518. 10.1016/S0735-1097(03)00717-4.CrossRefPubMed
41.
go back to reference Nilsson JC, Nielsen G, Groenning BA, Fritz-Hansen T, Sondergaard L, Jensen GB, et al: Sustained postinfarction myocardial oedema in humans visualised by magnetic resonance imaging. Heart. 2001, 85: 639-642. 10.1136/heart.85.6.639.PubMedCentralCrossRefPubMed Nilsson JC, Nielsen G, Groenning BA, Fritz-Hansen T, Sondergaard L, Jensen GB, et al: Sustained postinfarction myocardial oedema in humans visualised by magnetic resonance imaging. Heart. 2001, 85: 639-642. 10.1136/heart.85.6.639.PubMedCentralCrossRefPubMed
42.
go back to reference Ripa RS, Nilsson JC, Wang Y, Sondergaard L, Jorgensen E, Kastrup J: Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging. Am Heart J. 2007, 154: 929-936. 10.1016/j.ahj.2007.06.038.CrossRefPubMed Ripa RS, Nilsson JC, Wang Y, Sondergaard L, Jorgensen E, Kastrup J: Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging. Am Heart J. 2007, 154: 929-936. 10.1016/j.ahj.2007.06.038.CrossRefPubMed
43.
go back to reference Dent CL, Scott MJ, Wickline SA, Hall CS: High-frequency ultrasound for quantitative characterization of myocardial edema. Ultrasound Med Biol. 2000, 26: 375-384. 10.1016/S0301-5629(99)00144-1.CrossRefPubMed Dent CL, Scott MJ, Wickline SA, Hall CS: High-frequency ultrasound for quantitative characterization of myocardial edema. Ultrasound Med Biol. 2000, 26: 375-384. 10.1016/S0301-5629(99)00144-1.CrossRefPubMed
44.
go back to reference Powell WJ, wittenberg J, Maturi RA, Dinsmore RE, Miller SW: Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts. Circulation. 1977, 55: 99-108.CrossRefPubMed Powell WJ, wittenberg J, Maturi RA, Dinsmore RE, Miller SW: Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts. Circulation. 1977, 55: 99-108.CrossRefPubMed
45.
go back to reference Mahnken AH, Bruners P, Bornikoel CM, Kramer N, Guenther RW: Assessment of myocardial edema by computed tomography in myocardial infarction. JACC Cardiovasc Imaging. 2009, 2: 1167-1174. 10.1016/j.jcmg.2009.05.014.CrossRefPubMed Mahnken AH, Bruners P, Bornikoel CM, Kramer N, Guenther RW: Assessment of myocardial edema by computed tomography in myocardial infarction. JACC Cardiovasc Imaging. 2009, 2: 1167-1174. 10.1016/j.jcmg.2009.05.014.CrossRefPubMed
46.
go back to reference Abdel-Aty H, Simonetti O, Friedrich MG: T2-weighted cardiovascular magnetic resonance imaging. J Magn Reson Imaging. 2007, 26: 452-459. 10.1002/jmri.21028.CrossRefPubMed Abdel-Aty H, Simonetti O, Friedrich MG: T2-weighted cardiovascular magnetic resonance imaging. J Magn Reson Imaging. 2007, 26: 452-459. 10.1002/jmri.21028.CrossRefPubMed
47.
go back to reference Edwards NC, Routledge H, Steeds RP: T2-weighted magnetic resonance imaging to assess myocardial oedema in ischaemic heart disease. Heart. 2009, 95: 1357-1361. 10.1136/hrt.2009.169961.CrossRefPubMed Edwards NC, Routledge H, Steeds RP: T2-weighted magnetic resonance imaging to assess myocardial oedema in ischaemic heart disease. Heart. 2009, 95: 1357-1361. 10.1136/hrt.2009.169961.CrossRefPubMed
48.
go back to reference Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, et al: Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol. 1983, 52: 184-188. 10.1016/0002-9149(83)90093-0.CrossRefPubMed Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, et al: Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol. 1983, 52: 184-188. 10.1016/0002-9149(83)90093-0.CrossRefPubMed
49.
go back to reference Hazlewood CF, Chang DC, Nichols BL, Woessner DE: Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J. 1974, 14: 583-606. 10.1016/S0006-3495(74)85937-0.PubMedCentralCrossRefPubMed Hazlewood CF, Chang DC, Nichols BL, Woessner DE: Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J. 1974, 14: 583-606. 10.1016/S0006-3495(74)85937-0.PubMedCentralCrossRefPubMed
50.
go back to reference Knight RA, Ordidge RJ, Helpern JA, Chopp M, Rodolosi LC, Peck D: Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Stroke. 1991, 22: 802-808.CrossRefPubMed Knight RA, Ordidge RJ, Helpern JA, Chopp M, Rodolosi LC, Peck D: Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Stroke. 1991, 22: 802-808.CrossRefPubMed
51.
go back to reference Simonetti OP, Finn JP, White RD, Laub G, Henry DA: "Black blood" T2-weighted inversion-recovery MR imaging of the heart. Radiology. 1996, 199: 49-57.CrossRefPubMed Simonetti OP, Finn JP, White RD, Laub G, Henry DA: "Black blood" T2-weighted inversion-recovery MR imaging of the heart. Radiology. 1996, 199: 49-57.CrossRefPubMed
52.
go back to reference Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, et al: An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001, 218: 215-223.CrossRefPubMed Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, et al: An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001, 218: 215-223.CrossRefPubMed
53.
go back to reference Mikami Y, Sakuma H, Nagata M, Ishida M, Kurita T, Komuro I, et al: Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction. AJR Am J Roentgenol. 2009, 193: W321-W326. 10.2214/AJR.09.2335.CrossRefPubMed Mikami Y, Sakuma H, Nagata M, Ishida M, Kurita T, Komuro I, et al: Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction. AJR Am J Roentgenol. 2009, 193: W321-W326. 10.2214/AJR.09.2335.CrossRefPubMed
54.
go back to reference Kellman P, Aletras AH, Mancini C, McVeigh ER, Arai AE: T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo. Magn Reson Med. 2007, 57: 891-897. 10.1002/mrm.21215.PubMedCentralCrossRefPubMed Kellman P, Aletras AH, Mancini C, McVeigh ER, Arai AE: T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo. Magn Reson Med. 2007, 57: 891-897. 10.1002/mrm.21215.PubMedCentralCrossRefPubMed
55.
go back to reference Aletras AH, Kellman P, Derbyshire JA, Arai AE: ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart. Magn Reson Med. 2008, 59: 229-235. 10.1002/mrm.21490.CrossRefPubMed Aletras AH, Kellman P, Derbyshire JA, Arai AE: ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart. Magn Reson Med. 2008, 59: 229-235. 10.1002/mrm.21490.CrossRefPubMed
56.
go back to reference Green JD, Clarke JR, Flewitt JA, Friedrich MG: Single-shot steady-state free precession can detect myocardial edema in patients: a feasibility study. J Magn Reson Imaging. 2009, 30: 690-695. 10.1002/jmri.21868.CrossRefPubMed Green JD, Clarke JR, Flewitt JA, Friedrich MG: Single-shot steady-state free precession can detect myocardial edema in patients: a feasibility study. J Magn Reson Imaging. 2009, 30: 690-695. 10.1002/jmri.21868.CrossRefPubMed
57.
go back to reference Giri S, Chung YC, Merchant A, Mihai G, Rajagopalan S, Raman SV, et al: T2 quantification for improved detection of myocardial edema. J Cardiovasc Magn Reson. 2009, 11: 56-10.1186/1532-429X-11-56.PubMedCentralCrossRefPubMed Giri S, Chung YC, Merchant A, Mihai G, Rajagopalan S, Raman SV, et al: T2 quantification for improved detection of myocardial edema. J Cardiovasc Magn Reson. 2009, 11: 56-10.1186/1532-429X-11-56.PubMedCentralCrossRefPubMed
58.
go back to reference Wince WB, Kim RJ: Molecular imaging: T2-weighted CMR of the area at risk--a risky business?. Nat Rev Cardiol. 2010, 7: 547-549. 10.1038/nrcardio.2010.124.CrossRefPubMed Wince WB, Kim RJ: Molecular imaging: T2-weighted CMR of the area at risk--a risky business?. Nat Rev Cardiol. 2010, 7: 547-549. 10.1038/nrcardio.2010.124.CrossRefPubMed
59.
go back to reference Keegan J, Gatehouse PD, Prasad SK, Firmin DN: Improved turbo spin-echo imaging of the heart with motion-tracking. J Magn Reson Imaging. 2006, 24: 563-570. 10.1002/jmri.20655.CrossRefPubMed Keegan J, Gatehouse PD, Prasad SK, Firmin DN: Improved turbo spin-echo imaging of the heart with motion-tracking. J Magn Reson Imaging. 2006, 24: 563-570. 10.1002/jmri.20655.CrossRefPubMed
60.
go back to reference Lockie T, Nagel E, Redwood S, Plein S: Use of cardiovascular magnetic resonance imaging in acute coronary syndromes. Circulation. 2009, 119: 1671-1681. 10.1161/CIRCULATIONAHA.108.816512.PubMedCentralCrossRefPubMed Lockie T, Nagel E, Redwood S, Plein S: Use of cardiovascular magnetic resonance imaging in acute coronary syndromes. Circulation. 2009, 119: 1671-1681. 10.1161/CIRCULATIONAHA.108.816512.PubMedCentralCrossRefPubMed
61.
go back to reference Steen H, Madadi-Schroeder M, Lehrke S, Lossnitzer D, Giannitsis E, Katus HA: Staged cardiovascular magnetic resonance for differential diagnosis of Troponin T positive patients with low likelihood for acute coronary syndrome. J Cardiovasc Magn Reson. 2010, 12: 51-10.1186/1532-429X-12-51.PubMedCentralCrossRefPubMed Steen H, Madadi-Schroeder M, Lehrke S, Lossnitzer D, Giannitsis E, Katus HA: Staged cardiovascular magnetic resonance for differential diagnosis of Troponin T positive patients with low likelihood for acute coronary syndrome. J Cardiovasc Magn Reson. 2010, 12: 51-10.1186/1532-429X-12-51.PubMedCentralCrossRefPubMed
62.
go back to reference Arai AE: Using magnetic resonance imaging to characterize recent myocardial injury: utility in acute coronary syndrome and other clinical scenarios. Circulation. 2008, 118: 795-796. 10.1161/CIRCULATIONAHA.108.797373.PubMedCentralCrossRefPubMed Arai AE: Using magnetic resonance imaging to characterize recent myocardial injury: utility in acute coronary syndrome and other clinical scenarios. Circulation. 2008, 118: 795-796. 10.1161/CIRCULATIONAHA.108.797373.PubMedCentralCrossRefPubMed
63.
go back to reference Assomull RG, Lyne JC, Keenan N, Gulati A, Bunce NH, Davies SW, et al: The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries. Eur Heart J. 2007, 28: 1242-1249. 10.1093/eurheartj/ehm113.CrossRefPubMed Assomull RG, Lyne JC, Keenan N, Gulati A, Bunce NH, Davies SW, et al: The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries. Eur Heart J. 2007, 28: 1242-1249. 10.1093/eurheartj/ehm113.CrossRefPubMed
64.
go back to reference Eitel I, Desch S, Sareban M, Fuernau G, Gutberlet M, Schuler G, et al: Prognostic significance and magnetic resonance imaging findings in aborted myocardial infarction after primary angioplasty. Am Heart J. 2009, 158: 806-813. 10.1016/j.ahj.2009.08.025.CrossRefPubMed Eitel I, Desch S, Sareban M, Fuernau G, Gutberlet M, Schuler G, et al: Prognostic significance and magnetic resonance imaging findings in aborted myocardial infarction after primary angioplasty. Am Heart J. 2009, 158: 806-813. 10.1016/j.ahj.2009.08.025.CrossRefPubMed
65.
go back to reference Masci PG, Ganame J, Strata E, Desmet W, Aquaro GD, Dymarkowski S, et al: Myocardial salvage by CMR correlates with LV remodeling and early ST-segment resolution in acute myocardial infarction. JACC Cardiovasc Imaging. 2010, 3: 45-51. 10.1016/j.jcmg.2009.06.016.CrossRefPubMed Masci PG, Ganame J, Strata E, Desmet W, Aquaro GD, Dymarkowski S, et al: Myocardial salvage by CMR correlates with LV remodeling and early ST-segment resolution in acute myocardial infarction. JACC Cardiovasc Imaging. 2010, 3: 45-51. 10.1016/j.jcmg.2009.06.016.CrossRefPubMed
66.
go back to reference Francone M, Bucciarelli-Ducci C, Carbone I, Canali E, Scardala L, Calabrese FA, et al: Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: Insight from cardiovascular magnetic resonance. J Am Coll Cardiol. 2009, 54: 2145-2153. 10.1016/j.jacc.2009.08.024.CrossRefPubMed Francone M, Bucciarelli-Ducci C, Carbone I, Canali E, Scardala L, Calabrese FA, et al: Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: Insight from cardiovascular magnetic resonance. J Am Coll Cardiol. 2009, 54: 2145-2153. 10.1016/j.jacc.2009.08.024.CrossRefPubMed
67.
go back to reference Wright J, Adriaenssens T, Dymarkowski S, Desmet W, Bogaert J: Quantification of myocardial area at risk with T2-weighted CMR: comparison with contrast-enhanced CMR and coronary angiography. JACC Cardiovasc Imaging. 2009, 2: 825-831. 10.1016/j.jcmg.2009.02.011.CrossRefPubMed Wright J, Adriaenssens T, Dymarkowski S, Desmet W, Bogaert J: Quantification of myocardial area at risk with T2-weighted CMR: comparison with contrast-enhanced CMR and coronary angiography. JACC Cardiovasc Imaging. 2009, 2: 825-831. 10.1016/j.jcmg.2009.02.011.CrossRefPubMed
68.
go back to reference Carlsson M, Ubachs JF, Hedstrom E, Heiberg E, Jovinge S, Arheden H: Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. JACC Cardiovasc Imaging. 2009, 2: 569-576. 10.1016/j.jcmg.2008.11.018.CrossRefPubMed Carlsson M, Ubachs JF, Hedstrom E, Heiberg E, Jovinge S, Arheden H: Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. JACC Cardiovasc Imaging. 2009, 2: 569-576. 10.1016/j.jcmg.2008.11.018.CrossRefPubMed
69.
go back to reference Thiele H, Sareban M, Engelhardt H, Eitel I, Gutberlet M, Schuler G: Reproducibility of myocardial salvage in acute myocardial infarction by the use of contrast-enhanced magnetic resonance imaging [abstract]. Circulation. 2009, 120 (Suppl): 300- Thiele H, Sareban M, Engelhardt H, Eitel I, Gutberlet M, Schuler G: Reproducibility of myocardial salvage in acute myocardial infarction by the use of contrast-enhanced magnetic resonance imaging [abstract]. Circulation. 2009, 120 (Suppl): 300-
70.
go back to reference Sorensson P, Heiberg E, Saleh N, Bouvier F, Caidahl K, Tornvall P, et al: Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography. J Cardiovasc Magn Reson. 2010, 12: 25-10.1186/1532-429X-12-25.PubMedCentralCrossRefPubMed Sorensson P, Heiberg E, Saleh N, Bouvier F, Caidahl K, Tornvall P, et al: Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography. J Cardiovasc Magn Reson. 2010, 12: 25-10.1186/1532-429X-12-25.PubMedCentralCrossRefPubMed
71.
go back to reference Berry C, Kellman P, Mancini C, Chen MY, Bandettini WP, Lowrey T, et al: Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction. Circ Cardiovasc Imaging. 2010, 3: 527-535. 10.1161/CIRCIMAGING.109.900761.PubMedCentralCrossRefPubMed Berry C, Kellman P, Mancini C, Chen MY, Bandettini WP, Lowrey T, et al: Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction. Circ Cardiovasc Imaging. 2010, 3: 527-535. 10.1161/CIRCIMAGING.109.900761.PubMedCentralCrossRefPubMed
72.
go back to reference Lowe JE, Reimer KA, Jennings RB: Experimental infarct size as a function of the amount of myocardium at risk. Am J Pathol. 1978, 90: 363-379.PubMedCentralPubMed Lowe JE, Reimer KA, Jennings RB: Experimental infarct size as a function of the amount of myocardium at risk. Am J Pathol. 1978, 90: 363-379.PubMedCentralPubMed
73.
go back to reference Reimer KA, Jennings RB, Cobb FR, Murdock RH, Greenfield JC, Becker LC, et al: Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models. Circ Res. 1985, 56: 651-665.CrossRefPubMed Reimer KA, Jennings RB, Cobb FR, Murdock RH, Greenfield JC, Becker LC, et al: Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models. Circ Res. 1985, 56: 651-665.CrossRefPubMed
74.
go back to reference Thiele H, Hildebrand L, Schirdewahn C, Eitel I, Adams V, Fürnau G, et al: High-dose N-Acetylcystein versus placebo to prevent contrast-induced nephropathy and myocardial reperfusion injury in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. J Am Coll Cardiol. 55: 2201-2209. 10.1016/j.jacc.2009.08.091. Thiele H, Hildebrand L, Schirdewahn C, Eitel I, Adams V, Fürnau G, et al: High-dose N-Acetylcystein versus placebo to prevent contrast-induced nephropathy and myocardial reperfusion injury in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. J Am Coll Cardiol. 55: 2201-2209. 10.1016/j.jacc.2009.08.091.
75.
go back to reference Lonborg J, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, et al: Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010, 3: 34-41. 10.1161/CIRCINTERVENTIONS.109.905521.CrossRefPubMed Lonborg J, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, et al: Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010, 3: 34-41. 10.1161/CIRCINTERVENTIONS.109.905521.CrossRefPubMed
76.
go back to reference Ganame J, Messalli G, Dymarkowski S, Rademakers FE, Desmet W, Van de Werf F, et al: Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Eur Heart J. 2009, 30: 1440-1449. 10.1093/eurheartj/ehp093.CrossRefPubMed Ganame J, Messalli G, Dymarkowski S, Rademakers FE, Desmet W, Van de Werf F, et al: Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Eur Heart J. 2009, 30: 1440-1449. 10.1093/eurheartj/ehp093.CrossRefPubMed
77.
go back to reference Beek AM, Nijveldt R, van Rossum AC: Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention. Int J Cardiovasc Imaging. 2010, 26: 49-55. 10.1007/s10554-009-9499-1.PubMedCentralCrossRefPubMed Beek AM, Nijveldt R, van Rossum AC: Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention. Int J Cardiovasc Imaging. 2010, 26: 49-55. 10.1007/s10554-009-9499-1.PubMedCentralCrossRefPubMed
78.
go back to reference Bekkers SC, Backes WH, Kim RJ, Snoep G, Gorgels AP, Passos VL, et al: Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging. Eur Radiol. 2009, 19: 2904-2912. 10.1007/s00330-009-1489-0.PubMedCentralCrossRefPubMed Bekkers SC, Backes WH, Kim RJ, Snoep G, Gorgels AP, Passos VL, et al: Detection and characteristics of microvascular obstruction in reperfused acute myocardial infarction using an optimized protocol for contrast-enhanced cardiovascular magnetic resonance imaging. Eur Radiol. 2009, 19: 2904-2912. 10.1007/s00330-009-1489-0.PubMedCentralCrossRefPubMed
79.
go back to reference Mather AN, Fairbairn TA, Ball SG, Greenwood JP, Plein S: Reperfusion haemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk. Heart. 2010, Mather AN, Fairbairn TA, Ball SG, Greenwood JP, Plein S: Reperfusion haemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk. Heart. 2010,
80.
go back to reference Lotan CS, Bouchard A, Cranney GB, Bishop SP, Pohost GM: Assessment of postreperfusion myocardial hemorrhage using proton NMR imaging at 1.5 T. Circulation. 1992, 86: 1018-1025.CrossRefPubMed Lotan CS, Bouchard A, Cranney GB, Bishop SP, Pohost GM: Assessment of postreperfusion myocardial hemorrhage using proton NMR imaging at 1.5 T. Circulation. 1992, 86: 1018-1025.CrossRefPubMed
81.
go back to reference Cannan C, Eitel I, Hare J, Kumar A, Friedrich M: Hemorrhage in the myocardium following infarction. JACC Cardiovasc Imaging. 2010, 3: 665-668. 10.1016/j.jcmg.2009.12.019.CrossRefPubMed Cannan C, Eitel I, Hare J, Kumar A, Friedrich M: Hemorrhage in the myocardium following infarction. JACC Cardiovasc Imaging. 2010, 3: 665-668. 10.1016/j.jcmg.2009.12.019.CrossRefPubMed
82.
go back to reference Ortiz-Perez JT, Meyers SN, Lee DC, Kansal P, Klocke FJ, Holly TA, et al: Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging. Eur Heart J. 2007, 28: 1750-1758. 10.1093/eurheartj/ehm212.CrossRefPubMed Ortiz-Perez JT, Meyers SN, Lee DC, Kansal P, Klocke FJ, Holly TA, et al: Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging. Eur Heart J. 2007, 28: 1750-1758. 10.1093/eurheartj/ehm212.CrossRefPubMed
83.
go back to reference Reimer KA, Lowe JE, Rasmussen MM, Jennings RB: The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977, 56: 786-794.CrossRefPubMed Reimer KA, Lowe JE, Rasmussen MM, Jennings RB: The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977, 56: 786-794.CrossRefPubMed
84.
go back to reference Verheugt FW, Gersh BJ, Armstrong PW: Aborted myocardial infarction: a new target for reperfusion therapy. Eur Heart J. 2006, 27: 901-904. 10.1093/eurheartj/ehi829.CrossRefPubMed Verheugt FW, Gersh BJ, Armstrong PW: Aborted myocardial infarction: a new target for reperfusion therapy. Eur Heart J. 2006, 27: 901-904. 10.1093/eurheartj/ehi829.CrossRefPubMed
85.
go back to reference Ubachs JF, Engblom H, Erlinge D, Jovinge S, Hedstrom E, Carlsson M, et al: Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection. J Cardiovasc Magn Reson. 2010, 12: 18-10.1186/1532-429X-12-18.PubMedCentralCrossRefPubMed Ubachs JF, Engblom H, Erlinge D, Jovinge S, Hedstrom E, Carlsson M, et al: Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection. J Cardiovasc Magn Reson. 2010, 12: 18-10.1186/1532-429X-12-18.PubMedCentralCrossRefPubMed
86.
go back to reference Jensen CJ, Bleckmann D, Eberle HC, Nassenstein K, Schlosser T, Sabin GV, et al: A simple MR algorithm for estimation of myocardial salvage following acute ST segment elevation myocardial infarction. Clin Res Cardiol. 2009, 98: 651-656. 10.1007/s00392-009-0051-z.CrossRefPubMed Jensen CJ, Bleckmann D, Eberle HC, Nassenstein K, Schlosser T, Sabin GV, et al: A simple MR algorithm for estimation of myocardial salvage following acute ST segment elevation myocardial infarction. Clin Res Cardiol. 2009, 98: 651-656. 10.1007/s00392-009-0051-z.CrossRefPubMed
87.
go back to reference Braunwald E, Kloner RA: The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation. 1982, 66: 1146-1149.CrossRefPubMed Braunwald E, Kloner RA: The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation. 1982, 66: 1146-1149.CrossRefPubMed
88.
go back to reference Klocke FJ: Cardiac magnetic resonance measurements of area at risk and infarct size in ischemic syndromes. J Am Coll Cardiol. 2010, 55: 2489-2490. 10.1016/j.jacc.2010.01.048.CrossRefPubMed Klocke FJ: Cardiac magnetic resonance measurements of area at risk and infarct size in ischemic syndromes. J Am Coll Cardiol. 2010, 55: 2489-2490. 10.1016/j.jacc.2010.01.048.CrossRefPubMed
Metadata
Title
T2-weighted cardiovascular magnetic resonance in acute cardiac disease
Authors
Ingo Eitel
Matthias G Friedrich
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Cardiovascular Magnetic Resonance / Issue 1/2011
Electronic ISSN: 1532-429X
DOI
https://doi.org/10.1186/1532-429X-13-13

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