Top

Journal of Cardiovascular Magnetic Resonance

Published in:

Open Access 01-01-2010 | Poster presentation

Micro-MRI phenotyping of a novel double-knockout mouse model of congenital heart disease

Authors: Jon O Cleary, Karen McCue, Anthony N Price, Sarah Beddow, Roger J Ordidge, Peter J Scambler, Mark F Lythgoe

Published in: Journal of Cardiovascular Magnetic Resonance | Special Issue 1/2010

Excerpt

CHARGE and DiGeorge syndromes are conditions with incidences of 1 in 10,000 and 1 in 4000 and are strongly associated with haploinsufficiency of specific genes (CHD7 and TBX1). Both conditions are characterised by cardiovascular defects. Knockout mouse models are an important tool for the identification and characterisation of genes implicated in congenital heart conditions. Micro-MRI is an emerging technique for high resolution cardiac phenotyping in a reduced time compared to conventional histology, enabling the acquisition of 3D images of multiple embryos in a single scan[1]. …

Cleary JO, Price AN, et al.: NMR Biomed. 2009, 22 (8): 857-866. 10.1002/nbm.1400.CrossRefPubMed

McCue K, Randall V, et al.: 06-P038. Mech of Dev. 2009, 126: S131-10.1016/j.mod.2009.06.264.CrossRef

Title: Micro-MRI phenotyping of a novel double-knockout mouse model of congenital heart disease
Authors: Jon O Cleary
Karen McCue
Anthony N Price
Sarah Beddow
Roger J Ordidge
Peter J Scambler
Mark F Lythgoe
Publication date: 01-01-2010
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue Special Issue 1/2010
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/1532-429X-12-S1-P1

At a glance: The STEP trials

Springer Medicine

Micro-MRI phenotyping of a novel double-knockout mouse model of congenital heart disease

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 1/2010

Spoiled Gradient Echo T2* iron-loading measurements of the liver and myocardium in 12 year old male with severely reduced cardiac function from Thalassemia Major

Contrast-enhanced mri patterns early and later after heart transplantation

Acceleration of whole heart and targeted coronary artery imaging at 3 T with a 32-channel coil

Navigator techniques for coronary MRA at 7 T

Additional impact of microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after st-elevation myocardial infarction - a comparison to traditional prognostic markers

The conundrum of ECG-gated carotid arterial imaging with navigator corrected respiratory motion