Published in:
Open Access
01-01-2010 | Technologist presentation
Spoiled Gradient Echo T2* iron-loading measurements of the liver and myocardium in 12 year old male with severely reduced cardiac function from Thalassemia Major
Authors:
Annette L Dahl, Taigang He
Published in:
Journal of Cardiovascular Magnetic Resonance
|
Special Issue 1/2010
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Excerpt
Beta-Thalassemia Major affects 60.000 births per annum world-wide, and a further 94 million carriers. Mutations in the β-globin gene results in severe anaemia, leaving patients dependent on blood transfusions throughout their life. Excessive absorption combined with transfusional haemosiderosis cause iron-overload in the myocardium and liver. There is a 50% mortality rate in Beta-Talassemia Major patients before the age of 35 due to iron overload, with cardiac failure being the main cause of death. …