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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2011

Open Access 01-12-2011 | Review

Trauma is danger

Authors: Paul F Hwang, Nancy Porterfield, Dylan Pannell, Thomas A Davis, Eric A Elster

Published in: Journal of Translational Medicine | Issue 1/2011

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Abstract

Background

Trauma is one of the leading causes of death in young adult patients. Many pre-clinical and clinical studies attempt to investigate the immunological pathways involved, however the true mediators remain to be elucidated. Herein, we attempt to describe the immunologic response to systemic trauma in the context of the Danger model.

Data Sources

A literature search using PubMed was used to identify pertinent articles describing the Danger model in relation to trauma.

Conclusions

Our knowledge of Danger signals in relation to traumatic injury is still limited. Danger/alarmin signals are the most proximal molecules in the immune response that have many possibilities for effector function in the innate and acquired immune systems. Having a full understanding of these molecules and their pathways would give us the ability to intervene at such an early stage and may prove to be more effective in blunting the post-injury inflammatory response unlike previously failed cytokine experiments.
Appendix
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Metadata
Title
Trauma is danger
Authors
Paul F Hwang
Nancy Porterfield
Dylan Pannell
Thomas A Davis
Eric A Elster
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2011
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-9-92

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