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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Poster presentation

Increased expression of A-kinase anchoring proteins in T cells from systemic lupus erythematosus patients

Authors: M J Pérez-Lorenzo, M Galindo, A J García-González, G Criado

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Deficient activation of protein kinase A (PKA) is a characteristic of T cells in systemic lupus erythematosus (SLE). A-kinase Anchoring Proteins (AKAPs) associate to and regulate the activity of PKA [1]. Furthermore, some AKAPs are expressed in T cells and influence their function [2]. Therefore, altered expression and/or function of AKAPs can play a role in the deregulated activity of PKA observed in SLE T cells. …
Literature
1.
Jarnaess E, Taskén K: Spatiotemporal control of cAMP signalling processes by anchored signalling complexes. Biochem Soc Trans. 2007, 35: 931-7. 10.1042/BST0350931.CrossRefPubMed
2.
Schillace RV, Carr SD: The role of Protein Kinase A and A Kinase Anchoring proteins in modulating T cell activation: Progress and future directions. Crit Rev Immunol. 2006, 26: 113-31.CrossRefPubMed
Metadata
Title
Increased expression of A-kinase anchoring proteins in T cells from systemic lupus erythematosus patients
Authors
M J Pérez-Lorenzo
M Galindo
A J García-González
G Criado
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-P49

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