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Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Oral presentation

Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis

Authors: G Courties, J Presumey, M Baron, V Escriou, P Van Lent, D Scherman, A Cantagrel, W Van den Berg, C Jorgensen, J-L Davignon, F Apparailly

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Monocytes play a key role in both the systemic and local progression of rheumatoid arthritis (RA) by producing molecules that participate to the inflammatory and catabolic events of disease pathogenesis (1). Recently, the spleen has been shown to contribute to the regulation of inflammation through monocytes that are able to exit and rapidly deploy to inflammatory sites (2). …
Literature
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2.
go back to reference Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P: Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009, 325: 612-616. 10.1126/science.1175202.PubMedCentralCrossRefPubMed Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P: Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009, 325: 612-616. 10.1126/science.1175202.PubMedCentralCrossRefPubMed
Metadata
Title
Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis
Authors
G Courties
J Presumey
M Baron
V Escriou
P Van Lent
D Scherman
A Cantagrel
W Van den Berg
C Jorgensen
J-L Davignon
F Apparailly
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-O3

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