Published in:
Open Access
01-11-2010 | Oral presentation
Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis
Authors:
G Courties, J Presumey, M Baron, V Escriou, P Van Lent, D Scherman, A Cantagrel, W Van den Berg, C Jorgensen, J-L Davignon, F Apparailly
Published in:
Journal of Translational Medicine
|
Special Issue 1/2010
Login to get access
Excerpt
Monocytes play a key role in both the systemic and local progression of rheumatoid arthritis (RA) by producing molecules that participate to the inflammatory and catabolic events of disease pathogenesis (1). Recently, the spleen has been shown to contribute to the regulation of inflammation through monocytes that are able to exit and rapidly deploy to inflammatory sites (2). …