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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Oral presentation

Linking genotype to cell function in chronic inflammation: analysis of the IL-23/Th17 axis in spondylarthropathy

Authors: M Roumier, M Coffre, H Law, C Salliot, M Dougados, E Bianchi, L Rogge

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

For two decades, Th1 cells have been implicated in the pathogenesis of chronic inflammatory diseases. This notion has been challenged by the discovery of IL-23 and Th17 cells as key players in mouse inflammatory disease models. Furthermore, recent genome wide association studies have found a strong association between spondylarthropathy (SpA, a group of chronic inflammatory rheumatisms) and the presence of single nucleotide polymorphisms at the IL-23R locus. …
Metadata
Title
Linking genotype to cell function in chronic inflammation: analysis of the IL-23/Th17 axis in spondylarthropathy
Authors
M Roumier
M Coffre
H Law
C Salliot
M Dougados
E Bianchi
L Rogge
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-O2

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