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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Invited lecture presentation

Crohn’s disease is caused by a failure of the innate immune response with major abnormalities in macrophage biology

Author: A W Segal

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Crohn’s disease is characterized by chronic inflammation primarily affecting the gastrointestinal tract. We tested the hypothesis that the disease is a form of immunodeficiency with an underlying impairment of the early innate immune response. …
Literature
1.
Marks DJ: Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet. 2006, 367 (9511): 668-78. 10.1016/S0140-6736(06)68265-2.CrossRefPubMed
2.
Smith AM: Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med. 2009, 206 (9): 1883-97. 10.1084/jem.20091233.PubMedCentralCrossRefPubMed
Metadata
Title
Crohn’s disease is caused by a failure of the innate immune response with major abnormalities in macrophage biology
Author
A W Segal
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-I6

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