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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Invited lecture presentation

Biomarkers inform clinical trials and pathogenesis in systemic sclerosis

Author: R Lafyatis

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Biomarkers of disease are becoming increasingly recognized as central in design of clinical trials. Biomarkers allow us to link what “might be” as defined by in vitro and animal model studies with what “is” happening in disease pathogenesis. In scleroderma or systemic sclerosis (SSc) this is particularly important for implementing new strategies for clinical trials and understanding pathogenesis. …
Literature
1.
Farina G, Lafyatis D, Lemaire R, Lafyatis R: A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2010, 62: 580-588. 10.1002/art.27220.PubMedCentralCrossRefPubMed
2.
Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R: Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One. 2010, 5:
3.
Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R: Poly(I:C) Drives Type I IFN- and TGFbeta-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis. J Invest Dermatol. 2010
4.
Metadata
Title
Biomarkers inform clinical trials and pathogenesis in systemic sclerosis
Author
R Lafyatis
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-I14

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