Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-12-2010 | Review

Biomedical informatics and translational medicine

Author: Indra Neil Sarkar

Published in: Journal of Translational Medicine | Issue 1/2010

Login to get access

Abstract

Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine. To this end, the fundamental aspects of biomedical informatics (e.g., bioinformatics, imaging informatics, clinical informatics, and public health informatics) may be essential in helping improve the ability to bring basic research findings to the bedside, evaluate the efficacy of interventions across communities, and enable the assessment of the eventual impact of translational medicine innovations on health policies. Here, a brief description is provided for a selection of key biomedical informatics topics (Decision Support, Natural Language Processing, Standards, Information Retrieval, and Electronic Health Records) and their relevance to translational medicine. Based on contributions and advancements in each of these topic areas, the article proposes that biomedical informatics practitioners ("biomedical informaticians") can be essential members of translational medicine teams.
Appendix
Available only for authorised users
Literature
1.
Shortliffe EH, Cimino JJ: Biomedical informatics: computer applications in health care and biomedicine. 2006, New York, NY: Springer, 3
2.
Greenes RA, Shortliffe EH: Commentary: Informatics in biomedicine and health care. Acad Med. 2009, 84: 818-820. 10.1097/ACM.0b013e3181a81f94.PubMed
3.
Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ: Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Acad Med. 2009, 84: 964-970. 10.1097/ACM.0b013e3181a8144d.PubMedPubMedCentral
4.
5.
Collen MF: Fifty years in medical informatics. Yearb Med Inform. 2006, 174-179.
6.
Haux R: Individualization, globalization and health--about sustainable information technologies and the aim of medical informatics. Int J Med Inform. 2006, 75: 795-808. 10.1016/j.ijmedinf.2006.05.045.PubMed
7.
Kuhn KA, Knoll A, Mewes HW, Schwaiger M, Bode A, Broy M, Daniel H, Feussner H, Gradinger R, Hauner H, Hofler H, Holzmann B, Horsch A, Kemper A, Krcmar H, Kochs EF, Lange R, Leidl R, Mansmann U, Mayr EW, Meitinger T, Molls M, Navab N, Nusslin F, Peschel C, Reiser M, Ring J, Rummeny EJ, Schlichter J, Schmid R: Informatics and medicine--from molecules to populations. Methods Inf Med. 2008, 47: 283-295.PubMed
8.
Embi PJ, Kaufman SE, Payne PR: Biomedical informatics and outcomes research: enabling knowledge-driven health care. Circulation. 2009, 120: 2393-2399. 10.1161/CIRCULATIONAHA.108.795526.PubMedPubMedCentral
9.
Payne PR, Johnson SB, Starren JB, Tilson HH, Dowdy D: Breaking the translational barriers: the value of integrating biomedical informatics and translational research. J Investig Med. 2005, 53: 192-200. 10.2310/6650.2005.00402.PubMed
10.
Payne PR, Embi PJ, Sen CK: Translational informatics: enabling high-throughput research paradigms. Physiol Genomics. 2009, 39: 131-140. 10.1152/physiolgenomics.00050.2009.PubMedPubMedCentral
11.
Woolf SH: The meaning of translational research and why it matters. JAMA. 2008, 299: 211-213. 10.1001/jama.2007.26.PubMed
12.
Westfall JM, Mold J, Fagnan L: Practice-based research--"Blue Highways" on the NIH roadmap. JAMA. 2007, 297: 403-406. 10.1001/jama.297.4.403.PubMed
13.
Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ: Unintended consequences of health information technology: A need for biomedical informatics. J Biomed Inform. 2009,
14.
Maojo V, Kulikowski C: Medical informatics and bioinformatics: integration or evolution through scientific crises?. Methods Inf Med. 2006, 45: 474-482.PubMed
15.
Kukafka R, O'Carroll PW, Gerberding JL, Shortliffe EH, Aliferis C, Lumpkin JR, Yasnoff WA: Issues and opportunities in public health informatics: a panel discussion. J Public Health Manag Pract. 2001, 7: 31-42.PubMed
16.
17.
Baxter P: Research priorities: Bless thee! Thou art translated. Dev Med Child Neurol. 2008, 50: 323-10.1111/j.1469-8749.2008.00323.x.PubMed
18.
Hersh WR: Medical informatics: improving health care through information. JAMA. 2002, 288: 1955-1958. 10.1001/jama.288.16.1955.PubMed
19.
Khoury MJ, Rich EC, Randhawa G, Teutsch SM, Niederhuber J: Comparative effectiveness research and genomic medicine: an evolving partnership for 21st century medicine. Genet Med. 2009, 11: 707-711. 10.1097/GIM.0b013e3181b99b90.PubMed
20.
21.
Evans WE, Relling MV: Pharmacogenomics: translating functional genomics into rational therapeutics. Science. 1999, 286: 487-491. 10.1126/science.286.5439.487.PubMed
22.
Vizirianakis IS: Pharmaceutical education in the wake of genomic technologies for drug development and personalized medicine. Eur J Pharm Sci. 2002, 15: 243-250. 10.1016/S0928-0987(02)00013-1.PubMed
23.
Ikekawa A, Ikekawa S: Fruits of human genome project and private venture, and their impact on life science. Yakugaku Zasshi. 2001, 121: 845-873. 10.1248/yakushi.121.845.PubMed
24.
Butler GS, Overall CM: Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov. 2009, 8: 935-948. 10.1038/nrd2945.PubMed
25.
Rajcevic U, Niclou SP, Jimenez CR: Proteomics strategies for target identification and biomarker discovery in cancer. Front Biosci. 2009, 14: 3292-3303. 10.2741/3452.
26.
Ratib O: Imaging informatics: from image management to image navigation. Yearb Med Inform. 2009, 167-172.
27.
Arenson RL, Andriole KP, Avrin DE, Gould RG: Computers in imaging and health care: now and in the future. J Digit Imaging. 2000, 13: 145-156. 10.1007/BF03168389.PubMedPubMedCentral
28.
Ratib O, Swiernik M, McCoy JM: From PACS to integrated EMR. Comput Med Imaging Graph. 2003, 27: 207-215. 10.1016/S0895-6111(02)00075-7.PubMed
29.
Kuzmak PM, Dayhoff RE: The VA's use of DICOM to integrate image data seamlessly into the online patient record. Proc AMIA Symp. 1999, 92-96.
30.
Costa BM, Fitzgerald KJ, Jones KM, Dunning Am T: Effectiveness of IT-based diabetes management interventions: a review of the literature. BMC Fam Pract. 2009, 10: 72-10.1186/1471-2296-10-72.PubMedPubMedCentral
31.
Hersh WR, Wallace JA, Patterson PK, Shapiro SE, Kraemer DF, Eilers GM, Chan BK, Greenlick MR, Helfand M: Telemedicine for the Medicare population: pediatric, obstetric, and clinician-indirect home interventions. Evid Rep Technol Assess (Summ). 2001, 1-32.
32.
Schreiber WE, Giustini DM: Pathology in the era of Web 2.0. Am J Clin Pathol. 2009, 132: 824-828. 10.1309/AJCPEC9FZSB4DEDH.PubMed
33.
Kawamoto K, Houlihan CA, Balas EA, Lobach DF: Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success. BMJ. 2005, 330: 765-10.1136/bmj.38398.500764.8F.PubMedPubMedCentral
34.
Mollon B, Chong J, Holbrook AM, Sung M, Thabane L, Foster G: Features predicting the success of computerized decision support for prescribing: a systematic review of randomized controlled trials. BMC Med Inform Decis Mak. 2009, 9: 11-10.1186/1472-6947-9-11.PubMedPubMedCentral
35.
Durieux P, Trinquart L, Colombet I, Nies J, Walton R, Rajeswaran A, Rege Walther M, Harvey E, Burnand B: Computerized advice on drug dosage to improve prescribing practice. Cochrane Database Syst Rev. 2008, CD002894-
36.
Frieden TR, Henning KJ: Public health requirements for rapid progress in global health. Glob Public Health. 2009, 4: 323-337. 10.1080/17441690903089430.PubMed
37.
Brownstein JS, Freifeld CC, Madoff LC: Digital disease detection--harnessing the Web for public health surveillance. N Engl J Med. 2009, 360: 2153-2155. 10.1056/NEJMp0900702. 2157PubMedPubMedCentral
38.
Barclay E: Predicting the next pandemic. Lancet. 2008, 372: 1025-1026. 10.1016/S0140-6736(08)61425-7.PubMed
39.
Heymann DL, Rodier GR: Hot spots in a wired world: WHO surveillance of emerging and re-emerging infectious diseases. Lancet Infect Dis. 2001, 1: 345-353. 10.1016/S1473-3099(01)00148-7.PubMed
40.
McDaniel AM, Schutte DL, Keller LO: Consumer health informatics: from genomics to population health. Nurs Outlook. 2008, 56: 216-223. 10.1016/j.outlook.2008.06.006. e213PubMed
41.
Houston TK, Ehrenberger HE: The potential of consumer health informatics. Semin Oncol Nurs. 2001, 17: 41-47. 10.1053/sonu.2001.20418.PubMed
42.
Pagon RA: Internet resources in Medical Genetics. Curr Protoc Hum Genet. 2006, Chapter 9 (Unit 9): 12-PubMed
43.
Fomous C, Mitchell JA, McCray A: 'Genetics home reference': helping patients understand the role of genetics in health and disease. Community Genet. 2006, 9: 274-278. 10.1159/000094477.PubMed
44.
Omenn GS: Public health genetics: an emerging interdisciplinary field for the post-genomic era. Annu Rev Public Health. 2000, 21: 1-13. 10.1146/annurev.publhealth.21.1.1.PubMed
45.
N AS: WHO EMRO's approach for supporting e-health in the Eastern Mediterranean Region. East Mediterr Health J. 2006, 12 (Suppl 2): S238-252.PubMed
46.
Mandl KD, Lee TH: Integrating medical informatics and health services research: the need for dual training at the clinical health systems and policy levels. J Am Med Inform Assoc. 2002, 9: 127-132. 10.1197/jamia.M0973.PubMedPubMedCentral
47.
Revere D, Turner AM, Madhavan A, Rambo N, Bugni PF, Kimball A, Fuller SS: Understanding the information needs of public health practitioners: a literature review to inform design of an interactive digital knowledge management system. J Biomed Inform. 2007, 40: 410-421. 10.1016/j.jbi.2006.12.008.PubMed
48.
Embi PJ, Payne PR: Clinical Research Informatics: Challenges, Opportunities and Definition for an Emerging Domain. J Am Med Inform Assoc. 2009, 16: 316-327. 10.1197/jamia.M3005.PubMedPubMedCentral
49.
50.
Oster S, Langella S, Hastings S, Ervin D, Madduri R, Phillips J, Kurc T, Siebenlist F, Covitz P, Shanbhag K, Foster I, Saltz J: caGrid 1.0: an enterprise Grid infrastructure for biomedical research. J Am Med Inform Assoc. 2008, 15: 138-149. 10.1197/jamia.M2522.PubMedPubMedCentral
51.
Keator DB, Grethe JS, Marcus D, Ozyurt B, Gadde S, Murphy S, Pieper S, Greve D, Notestine R, Bockholt HJ, Papadopoulos P: A national human neuroimaging collaboratory enabled by the Biomedical Informatics Research Network (BIRN). IEEE Trans Inf Technol Biomed. 2008, 12: 162-172. 10.1109/TITB.2008.917893.PubMedPubMedCentral
52.
53.
Osheroff JA, Teich JM, Middleton B, Steen EB, Wright A, Detmer DE: A roadmap for national action on clinical decision support. J Am Med Inform Assoc. 2007, 14: 141-145. 10.1197/jamia.M2334.PubMedPubMedCentral
54.
Duda RO, Shortliffe EH: Expert Systems Research. Science. 1983, 220: 261-268. 10.1126/science.6340198.PubMed
55.
Hripcsak G, Ludemann P, Pryor TA, Wigertz OB, Clayton PD: Rationale for the Arden Syntax. Comput Biomed Res. 1994, 27: 291-324. 10.1006/cbmr.1994.1023.PubMed
56.
De Clercq P, Kaiser K, Hasman A: Computer-Interpretable Guideline formalisms. Stud Health Technol Inform. 2008, 139: 22-43.PubMed
57.
Ohno-Machado L, Gennari JH, Murphy SN, Jain NL, Tu SW, Oliver DE, Pattison-Gordon E, Greenes RA, Shortliffe EH, Barnett GO: The guideline interchange format: a model for representing guidelines. J Am Med Inform Assoc. 1998, 5: 357-372.PubMedPubMedCentral
58.
Kashyap V, Morales A, Hongsermeier T: On implementing clinical decision support: achieving scalability and maintainability by combining business rules and ontologies. AMIA Annu Symp Proc. 2006, 414-418.
59.
Musen MA: Scalable software architectures for decision support. Methods Inf Med. 1999, 38: 229-238.PubMed
60.
Clancey W: The Epistemology of a Rule Based Expert System: A Framework for Explanation. Artificial Intelligence. 1983, 20: 215-251. 10.1016/0004-3702(83)90008-5.
61.
Pearl J: Probabilistic Reasoning in Intelligent Systems: Networks of Plausible Inference. 1988, San Francisco: Morgan Kaufmann Publishers, Inc
62.
de Dombal FT, Leaper DJ, Staniland JR, McCann AP, Horrocks JC: Computer-aided diagnosis of acute abdominal pain. Br Med J. 1972, 2: 9-13. 10.1136/bmj.2.5804.9.PubMedPubMedCentral
63.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25: 3389-3402. 10.1093/nar/25.17.3389.PubMedPubMedCentral
64.
Allen JE, Majoros WH, Pertea M, Salzberg SL: JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regions. Genome Biol. 2006, 7 (Suppl 1:S9): 1-13.PubMed
65.
Kundaje A, Middendorf M, Shah M, Wiggins CH, Freund Y, Leslie C: A classification-based framework for predicting and analyzing gene regulatory response. BMC Bioinformatics. 2006, 7 (Suppl 1): S5-10.1186/1471-2105-7-S1-S5.PubMedPubMedCentral
66.
Downing GJ, Boyle SN, Brinner KM, Osheroff JA: Information management to enable personalized medicine: stakeholder roles in building clinical decision support. BMC Med Inform Decis Mak. 2009, 9: 44-10.1186/1472-6947-9-44.PubMedPubMedCentral
67.
Kawamoto K, Lobach DF, Willard HF, Ginsburg GS: A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak. 2009, 9: 17-10.1186/1472-6947-9-17.PubMedPubMedCentral
68.
Lee HJ, Hwang SI, Han SM, Park SH, Kim SH, Cho JY, Seong CG, Choe G: Image-based clinical decision support for transrectal ultrasound in the diagnosis of prostate cancer: comparison of multiple logistic regression, artificial neural network, and support vector machine. Eur Radiol. 2009,
69.
Khorasani R: Clinical decision support in radiology: what is it, why do we need it, and what key features make it effective?. J Am Coll Radiol. 2006, 3: 142-143. 10.1016/j.jacr.2005.11.008.PubMed
70.
De Dombal FT: Computer-aided decision support--glittering prospects, practical problems, and Pandora's box. Baillieres Clin Obstet Gynaecol. 1990, 4: 841-849. 10.1016/S0950-3552(05)80347-5.PubMed
71.
Garg AX, Adhikari NK, McDonald H, Rosas-Arellano MP, Devereaux PJ, Beyene J, Sam J, Haynes RB: Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA. 2005, 293: 1223-1238. 10.1001/jama.293.10.1223.PubMed
72.
Berlin A, Sorani M, Sim I: A taxonomic description of computer-based clinical decision support systems. J Biomed Inform. 2006, 39: 656-667. 10.1016/j.jbi.2005.12.003.PubMed
73.
Hunt DL, Haynes RB, Hanna SE, Smith K: Effects of computer-based clinical decision support systems on physician performance and patient outcomes: a systematic review. JAMA. 1998, 280: 1339-1346. 10.1001/jama.280.15.1339.PubMed
74.
Sittig DF, Wright A, Osheroff JA, Middleton B, Teich JM, Ash JS, Campbell E, Bates DW: Grand challenges in clinical decision support. J Biomed Inform. 2008, 41: 387-392. 10.1016/j.jbi.2007.09.003.PubMedPubMedCentral
75.
Short D, Frischer M, Bashford J: Barriers to the adoption of computerised decision support systems in general practice consultations: a qualitative study of GPs' perspectives. Int J Med Inform. 2004, 73: 357-362.PubMed
76.
Kaplan B: Evaluating informatics applications--clinical decision support systems literature review. Int J Med Inform. 2001, 64: 15-37. 10.1016/S1386-5056(01)00183-6.PubMed
77.
Fieschi M, Dufour JC, Staccini P, Gouvernet J, Bouhaddou O: Medical decision support systems: old dilemmas and new paradigms?. Methods Inf Med. 2003, 42: 190-198.PubMed
78.
Payne TH: Computer decision support systems. Chest. 2000, 118: 47S-52S. 10.1378/chest.118.2_suppl.47S.PubMed
79.
Manley DK, Bravata DM: A decision framework for coordinating bioterrorism planning: lessons from the BioNet program. Am J Disaster Med. 2009, 4: 49-57.PubMed
80.
Buckeridge DL: Outbreak detection through automated surveillance: a review of the determinants of detection. J Biomed Inform. 2007, 40: 370-379. 10.1016/j.jbi.2006.09.003.PubMed
81.
Gesteland PH, Gardner RM, Tsui FC, Espino JU, Rolfs RT, James BC, Chapman WW, Moore AW, Wagner MM: Automated syndromic surveillance for the 2002 Winter Olympics. J Am Med Inform Assoc. 2003, 10: 547-554. 10.1197/jamia.M1352.PubMedPubMedCentral
82.
Wright A, Bates DW, Middleton B, Hongsermeier T, Kashyap V, Thomas SM, Sittig DF: Creating and sharing clinical decision support content with Web 2.0: Issues and examples. J Biomed Inform. 2009, 42: 334-346. 10.1016/j.jbi.2008.09.003.PubMed
83.
Watson MS, Epstein C, Howell RR, Jones MC, Korf BR, McCabe ER, Simpson JL: Developing a national collaborative study system for rare genetic diseases. Genet Med. 2008, 10: 325-329. 10.1097/GIM.0b013e31817b80fd.PubMed
84.
Allen J: Natural language understanding. 1995, Redwood City, Calif.: Benjamin/Cummings Pub. Co, 2
85.
Feldman R, Sanger J: The text mining handbook: advanced approaches in analyzing unstructured data. 2007, Cambridge; New York: Cambridge University Press
86.
Reiter E, Dale R: Building natural language generation systems. 2000, Casmbridge, U.K New York: Cambridge University Press
87.
Jurafsky D, Martin JH: Speech and language processing: an introduction to natural language processing, computational linguistics, and speech recognition. 2000, Upper Saddle River, N.J.: Prentice Hall
88.
89.
Scherf M, Epple A, Werner T: The next generation of literature analysis: integration of genomic analysis into text mining. Brief Bioinform. 2005, 6: 287-297. 10.1093/bib/6.3.287.PubMed
90.
Rzhetsky A, Iossifov I, Koike T, Krauthammer M, Kra P, Morris M, Yu H, Duboue PA, Weng W, Wilbur WJ, Hatzivassiloglou V, Friedman C: GeneWays: a system for extracting, analyzing, visualizing, and integrating molecular pathway data. J Biomed Inform. 2004, 37: 43-53. 10.1016/j.jbi.2003.10.001.PubMed
91.
Dang PA, Kalra MK, Blake MA, Schultz TJ, Stout M, Lemay PR, Freshman DJ, Halpern EF, Dreyer KJ: Natural language processing using online analytic processing for assessing recommendations in radiology reports. J Am Coll Radiol. 2008, 5: 197-204. 10.1016/j.jacr.2007.09.003.PubMed
92.
Kahn CE: Artificial intelligence in radiology: decision support systems. Radiographics. 1994, 14: 849-861.PubMed
93.
Xu S, McCusker J, Krauthammer M: Yale Image Finder (YIF): a new search engine for retrieving biomedical images. Bioinformatics. 2008, 24: 1968-1970. 10.1093/bioinformatics/btn340.PubMedPubMedCentral
94.
Dang PA, Kalra MK, Blake MA, Schultz TJ, Halpern EF, Dreyer KJ: Extraction of recommendation features in radiology with natural language processing: exploratory study. AJR Am J Roentgenol. 2008, 191: 313-320. 10.2214/AJR.07.3508.PubMed
95.
Meystre SM, Savova GK, Kipper-Schuler KC, Hurdle JF: Extracting information from textual documents in the electronic health record: a review of recent research. Yearb Med Inform. 2008, 128-144.
96.
97.
Dalal M, Feiner S, McKeown K, Jordan D, Allen B, alSafadi Y: MAGIC: an experimental system for generating multimedia briefings about post-bypass patient status. Proc AMIA Annu Fall Symp. 1996, 684-688.
98.
Jordan DA, McKeown KR, Concepcion KJ, Feiner SK, Hatzivassiloglou V: Generation and evaluation of intraoperative inferences for automated health care briefings on patient status after bypass surgery. J Am Med Inform Assoc. 2001, 8: 267-280.PubMedPubMedCentral
99.
Kukafka R, Bales ME, Burkhardt A, Friedman C: Human and automated coding of rehabilitation discharge summaries according to the International Classification of Functioning, Disability, and Health. J Am Med Inform Assoc. 2006, 13: 508-515. 10.1197/jamia.M2107.PubMedPubMedCentral
100.
Chapman WW, Dowling JN, Wagner MM: Generating a reliable reference standard set for syndromic case classification. J Am Med Inform Assoc. 2005, 12: 618-629. 10.1197/jamia.M1841.PubMedPubMedCentral
101.
Weeber M, Kors JA, Mons B: Online tools to support literature-based discovery in the life sciences. Brief Bioinform. 2005, 6: 277-286. 10.1093/bib/6.3.277.PubMed
102.
103.
Rebholz-Schuhman D, Cameron G, Clark D, van Mulligen E, Coatrieux JL, Del Hoyo Barbolla E, Martin-Sanchez F, Milanesi L, Porro I, Beltrame F, Tollis I, Lei Van der J: SYMBIOmatics: synergies in Medical Informatics and Bioinformatics--exploring current scientific literature for emerging topics. BMC Bioinformatics. 2007, 8 (Suppl 1): S18-10.1186/1471-2105-8-S1-S18.PubMedPubMedCentral
104.
105.
Lehmann HP: Aspects of electronic health record systems. 2006, New York: Springer, 2
106.
Hersh W: Evaluation of biomedical text-mining systems: lessons learned from information retrieval. Brief Bioinform. 2005, 6: 344-356. 10.1093/bib/6.4.344.PubMed
107.
Brennan PF, Aronson AR: Towards linking patients and clinical information: detecting UMLS concepts in e-mail. J Biomed Inform. 2003, 36: 334-341. 10.1016/j.jbi.2003.09.017.PubMed
108.
Huff SM: Clinical data exchange standards and vocabularies for messages. Proc AMIA Symp. 1998, 62-67.
109.
Cimino JJ, Zhu X: The practical impact of ontologies on biomedical informatics. Yearb Med Inform. 2006, 124-135.
110.
Klein GO: Standardization of health informatics--results and challenges. Methods Inf Med. 2002, 41: 261-270.PubMed
111.
Mattheus R: European standardization efforts: an important framework for medical imaging. Eur J Radiol. 1993, 17: 28-37. 10.1016/0720-048X(93)90025-I.PubMed
112.
Hammond WE, Jaffe C, Kush RD: Healthcare standards development. The value of nurturing collaboration. J AHIMA. 2009, 80: 44-50. quiz 51-42PubMed
113.
114.
Bodenreider O: Biomedical ontologies in action: role in knowledge management, data integration and decision support. Yearb Med Inform. 2008, 67-79.
115.
Rubin DL, Shah NH, Noy NF: Biomedical ontologies: a functional perspective. Brief Bioinform. 2008, 9: 75-90. 10.1093/bib/bbm059.PubMed
116.
Blake J: Bio-ontologies-fast and furious. Nat Biotechnol. 2004, 22: 773-774. 10.1038/nbt0604-773.PubMed
117.
Cimino JJ: Review paper: coding systems in health care. Methods Inf Med. 1996, 35: 273-284.PubMed
118.
Peden AH: An overview of coding and its relationship to standardized clinical terminology. Top Health Inf Manage. 2000, 21: 1-9.PubMed
119.
Eriksson H, Morin M, Jenvald J, Gursky E, Holm E, Timpka T: Ontology based modeling of pandemic simulation scenarios. Stud Health Technol Inform. 2007, 129: 755-759.PubMed
120.
Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001, 29: 365-371. 10.1038/ng1201-365.PubMed
121.
Bidgood WD, Horii SC, Prior FW, Van Syckle DE: Understanding and using DICOM, the data interchange standard for biomedical imaging. J Am Med Inform Assoc. 1997, 4: 199-212.PubMedPubMedCentral
122.
Blobel BG, Engel K, Pharow P: Semantic interoperability--HL7 Version 3 compared to advanced architecture standards. Methods Inf Med. 2006, 45: 343-353.PubMed
123.
Hammond WE: Health Level 7: an application standard for electronic medical data exchange. Top Health Rec Manage. 1991, 11: 59-66.PubMed
124.
Rosenbloom ST, Miller RA, Johnson KB, Elkin PL, Brown SH: A model for evaluating interface terminologies. J Am Med Inform Assoc. 2008, 15: 65-76. 10.1197/jamia.M2506.PubMedPubMedCentral
125.
Wade G, Rosenbloom ST: The impact of SNOMED CT revisions on a mapped interface terminology: terminology development and implementation issues. J Biomed Inform. 2009, 42: 490-493. 10.1016/j.jbi.2009.03.004.PubMedPubMedCentral
126.
Richesson RL, Krischer J: Data standards in clinical research: gaps, overlaps, challenges and future directions. J Am Med Inform Assoc. 2007, 14: 687-696. 10.1197/jamia.M2470.PubMedPubMedCentral
127.
128.
Lahteenmaki J, Leppanen J, Kaijanranta H: Interoperability of personal health records. Conf Proc IEEE Eng Med Biol Soc. 2009, 1: 1726-1729.
129.
Mykkanen J, Korpela M, Ripatti S, Rannanheimo J, Sorri J: Local, regional and national interoperability in hospital-level systems architecture. Methods Inf Med. 2007, 46: 470-475.PubMed
130.
Klein GO, Sottile PA, Endsleff F: Another HISA--the new standard: health informatics--service architecture. Stud Health Technol Inform. 2007, 129: 478-482.PubMed
131.
Marchibroda JM: Health information exchange policy and evaluation. J Biomed Inform. 2007, 40: S11-16.PubMed
132.
Ohmann C, Kuchinke W: Future developments of medical informatics from the viewpoint of networked clinical research. Interoperability and integration. Methods Inf Med. 2009, 48: 45-54.PubMed
133.
Lorence D, Sivaramakrishnan A: Technology assessment of resources for the emerging US e-health infrastructure: a proposed interoperability model. Int J Electron Healthc. 2006, 2: 291-303.PubMed
134.
135.
Prokosch HU, Ganslandt T: Perspectives for medical informatics. Reusing the electronic medical record for clinical research. Methods Inf Med. 2009, 48: 38-44.PubMed
136.
Burgun A, Bodenreider O: Accessing and integrating data and knowledge for biomedical research. Yearb Med Inform. 2008, 91-101.
137.
Harris MA: Developing an ontology. Methods Mol Biol. 2008, 452: 111-124. full_text.PubMed
138.
Lindberg DA, Humphreys BL, McCray AT: The Unified Medical Language System. Methods Inf Med. 1993, 32: 281-291.PubMed
139.
Humphreys BL, Lindberg DA: The UMLS project: making the conceptual connection between users and the information they need. Bull Med Libr Assoc. 1993, 81: 170-177.PubMedPubMedCentral
140.
Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA: National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. OMICS. 2006, 10: 185-198. 10.1089/omi.2006.10.185.PubMed
141.
Musen M, Shah N, Noy N, Dai B, Dorf M, Griffith N, Buntrock JD, Jonquet C, Montegut MJ, Rubin DL: BioPortal: Ontologies and Data Resources with the Click of a Mouse. AMIA Annu Symp Proc. 2008, 1223-1224.
142.
Pathak J, Solbrig HR, Buntrock JD, Johnson TM, Chute CG: LexGrid: A Framework for Representing, Storing, and Querying Biomedical Terminologies from Simple to Sublime. J Am Med Inform Assoc. 2009, 16: 305-315. 10.1197/jamia.M3006.PubMedPubMedCentral
143.
Bug WJ, Ascoli GA, Grethe JS, Gupta A, Fennema-Notestine C, Laird AR, Larson SD, Rubin D, Shepherd GM, Turner JA, Martone ME: The NIFSTD and BIRNLex vocabularies: building comprehensive ontologies for neuroscience. Neuroinformatics. 2008, 6: 175-194. 10.1007/s12021-008-9032-z.PubMedPubMedCentral
144.
Manning CD, Raghavan P, Schütze H: Introduction to information retrieval. 2008, New York: Cambridge University Press
145.
Siadaty MS, Harrison JH: Multi-database mining. Clin Lab Med. 2008, 28: 73-82. 10.1016/j.cll.2007.10.004. viPubMed
146.
Louie B, Mork P, Martin-Sanchez F, Halevy A, Tarczy-Hornoch P: Data integration and genomic medicine. J Biomed Inform. 2007, 40: 5-16. 10.1016/j.jbi.2006.02.007.PubMed
147.
148.
Galperin MY, Cochrane GR: Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009. Nucleic Acids Res. 2009, 37: D1-4. 10.1093/nar/gkn942.PubMedPubMedCentral
149.
Cadag E, Louie B, Myler PJ, Tarczy-Hornoch P: Biomediator data integration and inference for functional annotation of anonymous sequences. Pac Symp Biocomput. 2007, 343-354. full_text.
150.
Muller H, Michoux N, Bandon D, Geissbuhler A: A review of content-based image retrieval systems in medical applications-clinical benefits and future directions. Int J Med Inform. 2004, 73: 1-23. 10.1016/j.ijmedinf.2003.11.024.PubMed
151.
Hsu W, Antani S, Long LR, Neve L, Thoma GR: SPIRS: a Web-based image retrieval system for large biomedical databases. Int J Med Inform. 2009, 78 (Suppl 1): S13-24. 10.1016/j.ijmedinf.2008.09.006.PubMedPubMedCentral
152.
Maviglia SM, Yoon CS, Bates DW, Kuperman G: KnowledgeLink: impact of context-sensitive information retrieval on clinicians' information needs. J Am Med Inform Assoc. 2006, 13: 67-73. 10.1197/jamia.M1861.PubMedPubMedCentral
153.
Cimino J: Infobuttons: anticipatory passive decision support. AMIA Annu Symp Proc. 2008, 1203-1204.
154.
O'Carroll PW: Public health informatics and information systems. 2003, New York: Springer
155.
Zeng QT, Crowell J, Plovnick RM, Kim E, Ngo L, Dibble E: Assisting consumer health information retrieval with query recommendations. J Am Med Inform Assoc. 2006, 13: 80-90. 10.1197/jamia.M1820.PubMedPubMedCentral
156.
Jacquemart P, Zweigenbaum P: Towards a medical question-answering system: a feasibility study. Stud Health Technol Inform. 2003, 95: 463-468.PubMed
157.
Ruttenberg A, Clark T, Bug W, Samwald M, Bodenreider O, Chen H, Doherty D, Forsberg K, Gao Y, Kashyap V, Kinoshita J, Luciano J, Marshall MS, Ogbuji C, Rees J, Stephens S, Wong GT, Wu E, Zaccagnini D, Hongsermeier T, Neumann E, Herman I, Cheung KH: Advancing translational research with the Semantic Web. BMC Bioinformatics. 2007, 8 (Suppl 3): S2-10.1186/1471-2105-8-S3-S2.PubMedPubMedCentral
158.
Smith AK, Cheung KH, Yip KY, Schultz M, Gerstein MK: LinkHub: a Semantic Web system that facilitates cross-database queries and information retrieval in proteomics. BMC Bioinformatics. 2007, 8 (Suppl 3): S5-10.1186/1471-2105-8-S3-S5.PubMedPubMedCentral
159.
Mirhaji P, Zhu M, Vagnoni M, Bernstam EV, Zhang J, Smith JW: Ontology driven integration platform for clinical and translational research. BMC Bioinformatics. 2009, 10 (Suppl 2): S2-10.1186/1471-2105-10-S2-S2.PubMedPubMedCentral
160.
Honigman B, Lee J, Rothschild J, Light P, Pulling RM, Yu T, Bates DW: Using computerized data to identify adverse drug events in outpatients. J Am Med Inform Assoc. 2001, 8: 254-266.PubMedPubMedCentral
161.
Mangalampalli A, Rama C, Muthiyalian R, Jain AK: High-end clinical domain information systems for effective healthcare delivery. Int J Electron Healthc. 2007, 3: 208-219. 10.1504/IJEH.2007.013101.PubMed
162.
Ebidia A, Mulder C, Tripp B, Morgan MW: Getting data out of the electronic patient record: critical steps in building a data warehouse for decision support. Proc AMIA Symp. 1999, 745-749.
163.
Ledbetter CS, Morgan MW: Toward best practice: leveraging the electronic patient record as a clinical data warehouse. J Healthc Inf Manag. 2001, 15: 119-131.PubMed
164.
Greenes RA, Pappalardo AN, Marble CW, Barnett GO: Design and implementation of a clinical data management system. Comput Biomed Res. 1969, 2: 469-485. 10.1016/0010-4809(69)90012-3.PubMed
165.
Barnett GO: The application of computer-based medical-record systems in ambulatory practice. N Engl J Med. 1984, 310: 1643-1650.PubMed
166.
Institute of Medicine (U.S.). Committee on Improving the Patient Record, Dick RS, Steen EB, Detmer DE: The computer-based patient record: an essential technology for health care. 1997, Washington, D.C.: National Academy Press
167.
Sax U, Schmidt S: Integration of genomic data in Electronic Health Records--opportunities and dilemmas. Methods Inf Med. 2005, 44: 546-550.PubMed
168.
Thorisson GA, Muilu J, Brookes AJ: Genotype-phenotype databases: challenges and solutions for the post-genomic era. Nat Rev Genet. 2009, 10: 9-18. 10.1038/nrg2483.PubMed
169.
Hoffman MA: The genome-enabled electronic medical record. J Biomed Inform. 2007, 40: 44-46. 10.1016/j.jbi.2006.02.010.PubMed
170.
Law MY, Liu B, Chan LW: Informatics in radiology: DICOM-RT-based electronic patient record information system for radiation therapy. Radiographics. 2009, 29: 961-972. 10.1148/rg.294085073.PubMed
171.
Liu BJ: A knowledge-based imaging informatics approach for managing proton beam therapy of cancer patients. Technol Cancer Res Treat. 2007, 6: 77-84.PubMed
172.
Liu BJ, Law MY, Documet J, Gertych A: Image-assisted knowledge discovery and decision support in radiation therapy planning. Comput Med Imaging Graph. 2007, 31: 311-321. 10.1016/j.compmedimag.2007.02.006.PubMed
173.
Prevedello LM, Andriole KP, Khorasani RR: Informatics in radiology: integration of the medical imaging resource center into a teaching hospital network to allow single sign-on access. Radiographics. 2009, 29: 973-979. 10.1148/rg.294085736.PubMed
174.
Furuie SS, Rebelo MS, Moreno RA, Santos M, Bertozzo N, Motta GH, Pires FA, Gutierrez MA: Managing medical images and clinical information: InCor's experience. IEEE Trans Inf Technol Biomed. 2007, 11: 17-24. 10.1109/TITB.2006.879588.PubMed
175.
Iglehart JK: Budgeting for change--Obama's down payment on health care reform. N Engl J Med. 2009, 360: 1381-1383. 10.1056/NEJMp0901927.PubMed
176.
Shekelle PG, Morton SC, Keeler EB: Costs and benefits of health information technology. Evid Rep Technol Assess (Full Rep). 2006, 1-71.
177.
Chaudhry B, Wang J, Wu S, Maglione M, Mojica W, Roth E, Morton SC, Shekelle PG: Systematic review: impact of health information technology on quality, efficiency, and costs of medical care. Ann Intern Med. 2006, 144: 742-752.PubMed
178.
Balfour DC, Evans S, Januska J, Lee HY, Lewis SJ, Nolan SR, Noga M, Stemple C, Thapar K: Health information technology--results from a roundtable discussion. J Manag Care Pharm. 2009, 15: 10-17.PubMed
179.
Poon EG, Jha AK, Christino M, Honour MM, Fernandopulle R, Middleton B, Newhouse J, Leape L, Bates DW, Blumenthal D, Kaushal R: Assessing the level of healthcare information technology adoption in the United States: a snapshot. BMC Med Inform Decis Mak. 2006, 6: 1-10.1186/1472-6947-6-1.PubMedPubMedCentral
180.
Lombardo J, Burkom H, Elbert E, Magruder S, Lewis SH, Loschen W, Sari J, Sniegoski C, Wojcik R, Pavlin J: A systems overview of the Electronic Surveillance System for the Early Notification of Community-Based Epidemics (ESSENCE II). J Urban Health. 2003, 80: i32-42.PubMedPubMedCentral
181.
Bravata DM, McDonald KM, Smith WM, Rydzak C, Szeto H, Buckeridge DL, Haberland C, Owens DK: Systematic review: surveillance systems for early detection of bioterrorism-related diseases. Ann Intern Med. 2004, 140: 910-922.PubMed
182.
Poissant L, Pereira J, Tamblyn R, Kawasumi Y: The impact of electronic health records on time efficiency of physicians and nurses: a systematic review. J Am Med Inform Assoc. 2005, 12: 505-516. 10.1197/jamia.M1700.PubMedPubMedCentral
183.
Hayrinen K, Saranto K, Nykanen P: Definition, structure, content, use and impacts of electronic health records: a review of the research literature. Int J Med Inform. 2008, 77: 291-304. 10.1016/j.ijmedinf.2007.09.001.PubMed
184.
Persell DJ, Robinson CH: Detection and early identification in bioterrorism events. Fam Community Health. 2008, 31: 4-16.PubMed
185.
Tang PC, Ash JS, Bates DW, Overhage JM, Sands DZ: Personal health records: definitions, benefits, and strategies for overcoming barriers to adoption. J Am Med Inform Assoc. 2006, 13: 121-126. 10.1197/jamia.M2025.PubMedPubMedCentral
186.
Ball MJ, Gold J: Banking on health: Personal records and information exchange. J Healthc Inf Manag. 2006, 20: 71-83.PubMed
187.
Eysenbach G: Medicine 2.0: social networking, collaboration, participation, apomediation, and openness. J Med Internet Res. 2008, 10: e22-10.2196/jmir.1030.PubMedPubMedCentral
188.
Detmer D, Bloomrosen M, Raymond B, Tang P: Integrated personal health records: transformative tools for consumer-centric care. BMC Med Inform Decis Mak. 2008, 8: 45-10.1186/1472-6947-8-45.PubMedPubMedCentral
189.
Johnston D, Kaelber D, Pan EC, Bu D, Shah S, Hook JM, Middleton B: A framework and approach for assessing the value of personal health records (PHRs). AMIA Annu Symp Proc. 2007, 374-378.
190.
Wasson K, Cook ED, Helzlsouer K: Direct-to-consumer online genetic testing and the four principles: an analysis of the ethical issues. Ethics Med. 2006, 22: 83-91.PubMed
191.
Williams-Jones B: Where there's a web, there's a way: commercial genetic testing and the Internet. Community Genet. 2003, 6: 46-57. 10.1159/000069538.PubMed
192.
Weitzman ER, Kaci L, Mandl KD: Acceptability of a personally controlled health record in a community-based setting: implications for policy and design. J Med Internet Res. 2009, 11: e14-10.2196/jmir.1187.PubMedPubMedCentral
193.
Halamka JD, Mandl KD, Tang PC: Early experiences with personal health records. J Am Med Inform Assoc. 2008, 15: 1-7. 10.1197/jamia.M2562.PubMedPubMedCentral
194.
Zerhouni EA: Clinical research at a crossroads: the NIH roadmap. J Investig Med. 2006, 54: 171-173. 10.2310/6650.2006.X0016.PubMed
195.
Zerhouni EA: US biomedical research: basic, translational, and clinical sciences. JAMA. 2005, 294: 1352-1358. 10.1001/jama.294.11.1352.PubMed
196.
Choi BC, Pak AW: Multidisciplinarity, interdisciplinarity and transdisciplinarity in health research, services, education and policy: 1. Definitions, objectives, and evidence of effectiveness. Clin Invest Med. 2006, 29: 351-364.PubMed
197.
Choi BC, Pak AW: Multidisciplinarity, interdisciplinarity, and transdisciplinarity in health research, services, education and policy: 2. Promotors, barriers, and strategies of enhancement. Clin Invest Med. 2007, 30: E224-232.PubMed
198.
Choi BC, Pak AW: Multidisciplinarity, interdisciplinarity, and transdisciplinarity in health research, services, education and policy: 3. Discipline, inter-discipline distance, and selection of discipline. Clin Invest Med. 2008, 31: E41-48.PubMed
199.
van Bemmel JH: The young person's guide to biomedical informatics. Methods Inf Med. 2006, 45: 671-680.PubMed
200.
Friedman CP, Altman RB, Kohane IS, McCormick KA, Miller PL, Ozbolt JG, Shortliffe EH, Stormo GD, Szczepaniak MC, Tuck D, Williamson J: Training the next generation of informaticians: the impact of "BISTI" and bioinformatics--a report from the American College of Medical Informatics. J Am Med Inform Assoc. 2004, 11: 167-172. 10.1197/jamia.M1520.PubMedPubMedCentral
201.
Johnson SB, Friedman RA: Bridging the gap between biological and clinical informatics in a graduate training program. J Biomed Inform. 2007, 40: 59-66. 10.1016/j.jbi.2006.02.011.PubMed
202.
Hovenga EJ: Global health informatics education. Stud Health Technol Inform. 2000, 57: 3-14.PubMed
203.
Reichertz PL: Preparing for change: concepts and education in medical informatics. Comput Methods Programs Biomed. 1987, 25: 89-101. 10.1016/0169-2607(87)90044-7.PubMed
204.
Altman RB: The interactions between clinical informatics and bioinformatics: a case study. J Am Med Inform Assoc. 2000, 7: 439-443.PubMedPubMedCentral
205.
Maojo V, Martin-Sanchez F: Bioinformatics: towards new directions for public health. Methods Inf Med. 2004, 43: 208-214.PubMed
206.
Lyon J, Giuse NB, Williams A, Koonce T, Walden R: A model for training the new bioinformationist. J Med Libr Assoc. 2004, 92: 188-195.PubMedPubMedCentral
207.
Masys DR: Effects of current and future information technologies on the health care workforce. Health Aff (Millwood). 2002, 21: 33-41. 10.1377/hlthaff.21.5.33.
208.
Ball MJ, Douglas JV: Informatics programs in the United States and abroad. MD Comput. 1990, 7: 172-175.PubMed
209.
Severtson DJ, Pape L, Page CD, Shavlik JW, Phillips GN, Flatley Brennan P: Biomedical informatics training at the University of Wisconsin-Madison. Yearb Med Inform. 2007, 149-156.
210.
Greenes RA, Panchanathan S, Patel V, Silverman H, Shortliffe EH: Biomedical informatics in the desert--a new and unique program at Arizona State University. Yearb Med Inform. 2008, 150-156.
211.
Hersh WR: The full spectrum of biomedical informatics education at Oregon Health & Science University. Methods Inf Med. 2007, 46: 80-83.PubMed
212.
Kane MD, Brewer JL: An information technology emphasis in biomedical informatics education. J Biomed Inform. 2007, 40: 67-72. 10.1016/j.jbi.2006.02.006.PubMed
213.
Gerstein M, Greenbaum D, Cheung K, Miller PL: An interdepartmental Ph.D. program in computational biology and bioinformatics: the Yale perspective. J Biomed Inform. 2007, 40: 73-79. 10.1016/j.jbi.2006.02.008.PubMed
214.
Mantas J, Ammenwerth E, Demiris G, Hasman A, Haux R, Hersh W, Hovenga E, Lun KC, Marin H, Martin-Sanchez F, Wright G: Recommendations of the International Medical Informatics Association (IMIA) on Education in Biomedical and Health Informatics. Methods Inf Med. 2010, 49-
215.
King SB, MacDonald K: Metropolis redux: the unique importance of library skills in informatics. J Med Libr Assoc. 2004, 92: 209-217.PubMedPubMedCentral
216.
Stein L: Creating a bioinformatics nation. Nature. 2002, 417: 119-120. 10.1038/417119a.PubMed
217.
Contemporary issues in medicine--medical informatics and population health: report II of the Medical School Objectives Project. Acad Med. 1999, 74: 130-141.
218.
Yasnoff WA, O'Carroll PW, Koo D, Linkins RW, Kilbourne EM: Public health informatics: improving and transforming public health in the information age. J Public Health Manag Pract. 2000, 6: 67-75.PubMed
219.
Patel VL, Branch T, Cimino A, Norton C, Cimino JJ: Participant perceptions of the influences of the NLM-sponsored Woods Hole medical informatics course. J Am Med Inform Assoc. 2005, 12: 256-262. 10.1197/jamia.M1662.PubMedPubMedCentral
220.
Hersh W, Williamson J: Educating 10,000 informaticians by 2010: the AMIA 10 × 10 program. Int J Med Inform. 2007, 76: 377-382. 10.1016/j.ijmedinf.2007.01.003.PubMed
Metadata
Title
Biomedical informatics and translational medicine
Author
Indra Neil Sarkar
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-22

Other articles of this Issue 1/2010

Journal of Translational Medicine 1/2010 Go to the issue

Commentary

Introducing the Cancer Microenvironment Section of Journal of Translational Medicine

Research

Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

Research

Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial

Research

HSF1 overexpression enhances oncolytic effect of replicative adenovirus

Research

Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study

Research

Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits