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Open Access 01-12-2009 | Review

Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Doru T Alexandrescu, Thomas E Ichim, Neil H Riordan

Published in: Journal of Translational Medicine | Issue 1/2009

Abstract

Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving or even rejuvenating endothelial function offers a potent means of preventing/treating some of the most fearful aspects of aging such as loss of mental, cardiovascular, and sexual function.

Endothelial precursor cells (EPC) provide a continual source of replenishment for damaged or senescent blood vessels. In this review we discuss the biological relevance of circulating EPC in a variety of pathologies in order to build the case that these cells act as an endogenous mechanism of regeneration. Factors controlling EPC mobilization, migration, and function, as well as therapeutic interventions based on mobilization of EPC will be reviewed. We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects.

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Title: Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
Authors: Nina A Mikirova
James A Jackson
Ron Hunninghake
Julian Kenyon
Kyle WH Chan
Cathy A Swindlehurst
Boris Minev
Amit N Patel
Michael P Murphy
Leonard Smith
Doru T Alexandrescu
Thomas E Ichim
Neil H Riordan
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: Journal of Translational Medicine / Issue 1/2009
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/1479-5876-7-106

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