Published in:
Open Access
01-05-2014 | Poster presentation
Barasertib: a novel approach for the treatment of metastatic melanoma
Authors:
Amalia Azzariti, Letizia Porcelli, Anna Elisa Quatrale, Letizia Sidella, RM Iacobazzi, Gabriella Guida, Immacolata Maida, Tiziana Cocco, Anna Ferretta, Sabino Strippoli, Stefania Giuda, Stefani Tommasi, Angelo Paradiso, Michele Guida
Published in:
Journal of Translational Medicine
|
Special Issue 1/2014
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Excerpt
Metastatic melanoma represents the most deadly form of skin cancer. The poor response to chemotherapy and the brief response to the anti-BRAF vemurafenib in selected population of patients, make the identification of new therapeutic approaches an urgent need. Our goal is the evaluation of the efficacy of barasertib, an aurora B kinase inhibitor impairing cytokinesis, in both mutated and non-mutated melanoma cell lines. …