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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2014

Open Access 01-12-2014 | Review

Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer

Authors: Jiebai Zhou, Zhitu Zhu, Chunxue Bai, Hongzhi Sun, Xiangdong Wang

Published in: Journal of Translational Medicine | Issue 1/2014

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Abstract

Lymphocytes play important roles in the balance between body defense and noxious agents involved in a number of diseases, e.g. autoimmune diseases, allergic inflammation and cancer. The proteomic analyses have been applied to identify and validate disease-associated and disease-specific biomarkers for therapeutic strategies of diseases. The proteomic profiles of lymphocytes may provide more information to understand their functions and roles in the development of diseases, although proteomic approaches in lymphocytes are still limited. The present review overviewed the proteomics-based studies on lymphocytes to headlight the proteomic profiles of lymphocytes in diseases, such as autoimmune diseases, allergic inflammation and cancer, with a special focus on lung diseases. We will explore the potential significance of diagnostic biomarkers and therapeutic targets from the current status in proteomic studies of lymphocytes and discuss the value of the currently available proteomic methodologies in the lymphocytes research.
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Metadata
Title
Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer
Authors
Jiebai Zhou
Zhitu Zhu
Chunxue Bai
Hongzhi Sun
Xiangdong Wang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2014
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-12-6

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