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Thrombosis Journal
Published in: Thrombosis Journal 1/2004

Open Access 01-12-2004 | Review

The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?

Authors: Raul Altman, Héctor L Luciardi, Juan Muntaner, Ramón N Herrera

Published in: Thrombosis Journal | Issue 1/2004

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Excerpt

Cyclooxygenase-1 [COX-1, prostaglandin synthase] catalyses the transformation of arachidonic acid to the unstable intermediate prostaglandin PGH2. Subsequently, thromboxane synthase acts on PGH2 to form TXA2, a transient biological product that induces platelet aggregation and is a powerful vasoconstrictor. Aspirin acts primarily by interfering with the biosynthesis of cyclic prostanoids: TXA2, prostacyclin, and other prostaglandins. It irreversibly inhibits COX-1 by acetylation of serine-530 and induces a long-lasting functional defect in the platelets. The resultant decrease in production of prostaglandins and TXA2 probably accounts for much of aspirin's antithrombotic effect [1, 2]. The plasma half-life of aspirin is only 20 min in circulating blood. It is rapidly deacetylated and converted to salicylate in vivo. Salicylate does not affect COX-1 or COX-2 activity [3]. …
Literature
1.
FitzGerald GA: Parsing an enigma: the pharmacodynamics of aspirin resistance. Lancet 2003, 361: 542-4. 10.1016/S0140-6736(03)12560-3CrossRefPubMed
2.
3.
4.
Gurfinkel EP, Altman R, Scazziota A, Heguilen R, Mautner B: Fast platelet suppression by lysine acetylsalicylate in chronic stable coronary patients. Potential clinical impact over regular aspirin for coronary syndromes. Clin Cardiol 2000, 23(9):697-700.CrossRefPubMed
5.
Patrignani P, Filabozi P, Patrono C: Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982, 69: 1366-72.PubMedCentralCrossRefPubMed
6.
Reilly IAG, FitzGerald GA: Inhibition of thromboxane formation in vivo and ex vivo. Blood 1987, 69: 180-6.PubMed
7.
Hoogendijk EMG, ten Cate JW: Aspirin and platelets. Lancet 1980, 1: 93-4. 10.1016/S0140-6736(80)90516-4CrossRefPubMed
8.
Jakubowski JA, Stampfer MJ, Vaillancourt R, Deykin D: Cumulative antiplatelet effect of low-dose enteric coated aspirin. Br J Haematol 1982, 60: 635-42.CrossRef
9.
Vane JR, Bakhle YS, Botting RM: Cyclooxygenases 1 and 2. Ann Rev Pharmacol Toxicol 1998, 38: 97-120. 10.1146/annurev.pharmtox.38.1.97CrossRef
10.
de Gaetano G, Donati MB, Cerletti C: Prevention on thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors. Trends Pharmacol Sci 2003, 24: 245-52.CrossRefPubMed
11.
FitzGerald GA, Oates JA, Hawiger J, Maas RL, Roberts LJ 2nd, Lawson JA, Brash AR: Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 1983, 71: 676-88.PubMedCentralCrossRefPubMed
12.
Preston FE, Whipps S, Jackson CA, French AJ, Wyld PJ, Stoddard CJ: Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin. N Engl J Med 1981, 304: 76-9.CrossRefPubMed
13.
Antithrombotic Trialists' Collaboration: Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002, 324: 71-86. 10.1136/bmj.324.7336.S71CrossRef
14.
Syrbe G, Redlich H, Weidlich B, et al.: Individual dosing of ASA prophylaxis by controlling platelet aggregation. Clin Appl Thromb Hemost 2001, 7: 209-13.CrossRefPubMed
15.
Schafer AI: Genetic and Acquired Determinants of Individual Variability of Response to Antiplatelet Drugs. Circulation 2003, 108: 910-1. 10.1161/01.CIR.0000088843.52678.8ACrossRefPubMed
16.
Valles J, Santos MT, Aznar J, Osa A, Lago A, Cosin J, Sanchez E, Broekman MJ, Marcus AJ: Erythrocyte promotion of platelet reactivity decreases the effectiveness of aspirin as an antithrombotic therapeutic modality: the effect of low-dose aspirin is less than optimal in patients with vascular disease due to prothrombotic effects of erythrocytes on platelet reactivity. Circulation 1998, 97: 350-5.CrossRefPubMed
17.
Tarjan J, Salamon A, Jager R, Poor F, Barczi V, Dinnyes J, Hamvas J, Kinczel A, Pal A, Blasko G: The rate of acetylsalicylic acid non-respondents among patients hospitalized for acute coronary disease, previously undergoing secondary salicylic acid prophylaxis. Orv Hetil 1999, 140: 2339-43.PubMed
18.
Zimmermann N, Wenk A, Kim U, Kienzle P, Weber AA, Gams E, Schrör K, Hohlfeld T: Functional and Biochemical Evaluation of Platelet Aspirin Resistance After Coronary Artery Bypass Surgery. Circulation 2003, 108: 542-7. 10.1161/01.CIR.0000081770.51929.5ACrossRefPubMed
19.
Gum PA, Kottke-Marchant K, Poggio ED, Gurm H, Welsh PA, Brooks L, Sapp SK, Topol EJ: Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am J Cardiol 2001, 88: 230-5. 10.1016/S0002-9149(01)01631-9CrossRefPubMed
20.
Kundu SK, Heilmann EJ, Sio R, Garcia C, Davidson RM, Ostgaard RA: Description of an in vitro platelet function analyzer – PFA-100. Semin Thromb Hemost 1995, 21(Suppl 2):106-12.PubMed
21.
ten Berg JM, Gerritsen WB, Haas FJ, Kelder HC, Verheugt FW, Plokker HW: High-dose aspirin in addition to daily low-dose aspirin decreases platelet activation in patients before and after percutaneous coronary intervention. Thromb Res 2002, 105: 385-90. 10.1016/S0049-3848(02)00040-3CrossRefPubMed
22.
Gum PA, Kottke-Marchant K, Welsh PA, White J, Topol EJ: A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol 2003, 41: 961-5. 10.1016/S0735-1097(02)03014-0CrossRefPubMed
23.
Grundmann K, Jaschonek K, Kleine B, Dichgans J, Topka H: Aspirin non-responder status in patients with recurrent cerebral ischemic attacks. J Neurol 2003, 250: 63-6. 10.1007/s00415-003-0954-yCrossRefPubMed
24.
Eikelboom JW, Hirsh J, Weitz JI, Johnston M, Yi Q, Yusuf S: Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 2002, 105: 1650-5. 10.1161/01.CIR.0000013777.21160.07CrossRefPubMed
25.
Sane DC, McKee SA, Malinin AI, Serebruany VL: Frequency of aspirin resistance in patients with congestive heart failure treated with antecedent aspirin. Am J Cardiol 2002, 90: 893-5. 10.1016/S0002-9149(02)02718-2CrossRefPubMed
26.
27.
Kurth T, Glynn RJ, Walker AM, Chan KA, Buring JE, Hennekens CH, Gaziano JM: Inhibition of Clinical Benefits of Aspirin on First Myocardial Infarction by Nonsteroidal Antiinflammatory Drugs. Circulation 2003, 108: 1191-5. 10.1161/01.CIR.0000087593.07533.9BCrossRefPubMed
28.
Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B, Vyas SN, FitzGerald GA: Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 2001, 345: 1809-17. 10.1056/NEJMoa003199CrossRefPubMed
29.
Li N, Hu H, Hjemdahl P: Aspirin treatment does not alternate platelet or leukocyte activation as monitored by whole blood flow cytometry. Thromb Res 2003, 111: 165-170. 10.1046/j.1538-7836.2003.00354.xCrossRefPubMed
30.
Maalej N, Folts JD: Increased shear stress overcomes the antithrombotic platelet inhibitory effect of aspirin in stenosed dog coronary arteries. Circulation 1996, 93: 1201-5.CrossRefPubMed
31.
Mehta J, Mehta P, Burger C, Pepine CJ: Platelet aggregation studies in coronary artery disease. Past 4. Effect of aspirin. Atherosclerosis 1978, 31: 169-75.CrossRefPubMed
32.
Santos MT, Valles J, Aznar J, Marcus AJ, Broekman MJ, Safier LB: Prothrombotic effects of erythrocytes on platelet reactivity. Reduction by aspirin. Circulation 1997, 95: 63-8.CrossRefPubMed
33.
Altman R, Scazziota A: Why aspirin cannot prevent arterial thrombosis. Circulation 1996, 94: 3002-3.CrossRefPubMed
34.
Altman R, Scazziota A, Cordero Funes J: Why single daily dose of aspirin may not prevent platelet aggregation. Thromb Res 1988, 51: 259-66.CrossRefPubMed
35.
Altman R, Scazziota A: Synergistic actions of paf-acether and sodium arachidonate in human platelet aggregation. 2. Unexpected results after aspirin intake. Thromb Res 1986, 43: 113-20.CrossRefPubMed
36.
Bartele V, Cerletti C, Schiepatti A, di Minno G, de Gaetano G: Inhibition of thromboxane synthetase does not necessarily prevent platelet aggregation. Lancet 1981, 1: 1057-8. 10.1016/S0140-6736(81)92224-8CrossRefPubMed
37.
Cerletti C, Carriero MR, de Gaetano G: Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. N Engl J Med 1986, 314: 316-8.PubMed
38.
Patrono C: Aspirin resistance: definition, mechanism and clinical read-outs. J Thromb Haemost 2003, 1: 1710-13. 10.1046/j.1538-7836.2003.00284.xCrossRefPubMed
39.
de Gaetano G, Cerletti C: Aspirin resistance: a revival of platelet aggregation tests? J Thromb Haemost 2003, 1: 2048-50. 10.1046/j.1538-7836.2003.00354.xCrossRefPubMed
40.
Cambia-Kiely JA, Gandhi PJ: Possible mechanism of aspirin resistance. J Thromb Thrombolysis 2002, 13: 49-56. 10.1023/A:1015324310374CrossRef
41.
Weber AA, Przytulski B, Schanz A, Hohlfeld T, Schror K: Towards a definition of aspirin resistance: a typological approach. Platelets 2002, 13: 37-40. 10.1080/09537100120104890CrossRefPubMed
42.
Koksch M, Zeiger F, Wittig K, Siegemund A, Reininger CB, Pfeiffer D, Ruehlmann C: Coagulation, fibrinolysis and platelet P-selectin expression in peripheral vascular disease. Eur J Vasc Endovasc Surg 2001, 21: 147-54. 10.1053/ejvs.2000.1294CrossRefPubMed
43.
Weber AA, Zimmermann KC, Meyer-Kirchrath J, Schror K: Cyclooxygenase-2 in human platelets as a possible factor in aspirin resistance. Lancet 1999, 353: 900. 10.1016/S0140-6736(99)00498-5CrossRefPubMed
44.
Patrignani P, Sciulli MG, Manarini S, Santini G, Cerletti C, Evangelista V: [COX-2 is not involved in thromboxane biosynthesis by activated human platelets. J Physiol Pharmacol 1999, 50: 661-7.PubMed
45.
Kawasaki T, Ozeki Y, Igawa T, Kambayashi J: Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin. Stroke 2000, 31: 591-5.CrossRefPubMed
46.
Macchi L, Christiaens L, Brabant S, Sorel N, Allal J, Mauco G, Brizard A: Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate. Thromb Res 2002, 107: 45-9. 10.1016/S0049-3848(02)00210-4CrossRefPubMed
47.
Buchanan MR, Brister SJ: Individual variation in the effects of ASA on platelet function: implications for the use of ASA clinically. Can J Cardiol 1995, 11: 221-7.PubMed
48.
Andersen K, Hurlen M, Arnesen H, Seljeflot I: Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease. Thromb Res 2002, 108: 37-42. 10.1016/S0049-3848(02)00405-XCrossRefPubMed
49.
Muller I, Besta F, Schulz C, Massberg S, Schonig A, Gawaz M: Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost 2003, 89: 783-7.PubMed
50.
Halushka MK, Halushka PV: Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2? Circulation 2002, 105: 1620-2. 10.1161/01.CIR.0000015422.86569.52CrossRefPubMed
51.
Cipollone F, Prontera C, Pini B, Marini M, Fazia M, De Cesare D, Iezzi A, Ucchino S, Boccoli G, Saba V, Chiarelli F, Cuccurullo F, Mezzetti A: Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E2-dependent plaque instability. Circulation 2001, 104: 921-7.CrossRefPubMed
52.
Cipollone F, Patrignani P, Greco A, Panara MR, Padovano R, Cuccurullo F, Patrono C, Rebuzzi AG, Liuzzo G, Quaranta G, Maseri A: Differential Suppression of Thromboxane Biosynthesis by Indobufen and Aspirin in Patients With Unstable Angina. Circulation 1997, 96: 1109-16.CrossRefPubMed
53.
54.
Cyrus T, Sung S, Zhao L, Funk CD, Tang S, Praticò D: Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 2002, 106: 1282-7. 10.1161/01.CIR.0000027816.54430.96CrossRefPubMed
55.
Redondo S, Santos-Gallego CG, Ganado P, Garcia M, Rico L, Del Rio M, Tejerina T: Acetylsalicylic acid inhibits cell proliferation by involving transforming growth factor-β. Circulation 2003, 107: 626-9. 10.1161/01.CIR.0000045664.75269.A5CrossRefPubMed
56.
Kodama M, Yamasaki Y, Sakamoto K, Yoshioka R, Matsuhisa M, Kajimoto Y, Kosugi K, Ueda N, Hori M: Antiplatelet drugs attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes. Thromb Res 2000, 97: 239-45. 10.1016/S0049-3848(99)00168-1CrossRefPubMed
57.
Altman R, Scazziota A, Rouvier J, Gonzalez C: Effect of sodium arachidonate on thrombin generation through platelet activation.-Inhibitory effect of aspirin. Thromb Haemostas 2000, 54: 1109-12.
58.
Kharbanda RK, Walton B, Allen M, Klein N, Hingorani AD, MacAllister RJ, Vallance P: Prevention of inflammation-induced endothelial dysfunction. A novel vasculo-protective action of aspirin. Circulation 2002, 105: 2600-4. 10.1161/01.CIR.0000017863.52347.6CCrossRefPubMed
59.
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH: Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men. N Engl J Med 1997, 336: 973-9. 10.1056/NEJM199704033361401CrossRefPubMed
60.
Bhatt DL, Topol EJ: Need to test the arterial inflammation hypothesis. Circulation 2002, 106: 136-140. 10.1161/01.CIR.0000021112.29409.A2CrossRefPubMed
61.
Patrizia Ferroni MD, Francesca Martini PhD, Cristiano M, Cardarello MD, Pier Paolo Gazzaniga MD, Giovanni Davì MD, Stefania Basili MD: Enhanced Interleukin-1β in Hypercholesterolemia. Effects of Simvastatin and Low-Dose Aspirin. Circulation 2003, 108: 1673-5. 10.1161/01.CIR.0000094732.02060.27CrossRefPubMed
62.
Bjornsson TD, Schneider DE, Berger H Jr: Aspirin acetylates fibrinogen and enhances fibrinolysis: fibrinolytic effect is independent of changes in plasminogen activator levels. J Pharmacol Exp Ther 1989, 250: 154-161.PubMed
63.
Ezratty A, Freedman JE, Simon D, Loscalzo J: The antithrombotic effects of acetylation of fibrinogen by aspirin. J Vasc Med Biol 1994, 5: 152-9.
64.
Williams S, Fatah K, Hjemdahl P, Blomback M: Better increase in fibrin gel porosity by low dose than intermediate dose acetylsalicylic acid. Eur Heart J 1998, 19: 1666-72. 10.1053/euhj.1998.1088CrossRefPubMed
65.
Watala C, Gwozdzinski K: Effect of aspirin on conformation and dynamics of membrane proteins in platelets and erythrocytes. Biochem Pharmacol 1993, 45: 1343-1. 10.1016/0006-2952(93)90288-8CrossRefPubMed
66.
Bozza PT, Payne JL, Morham SG, Langenbach R, Smithies O, Weller PF: Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. Proc Natl Acad Sci U S A 1996, 93: 11091-6. 10.1073/pnas.93.20.11091PubMedCentralCrossRefPubMed
67.
Lopez-Farre A, Caramelo C, Esteban A, Alberola ML, Millas I, Monton M, Casado S: Effects of aspirin on platelet-neutrophil interactions: role of nitric oxide and endothelin-1. Circulation 1995, 91: 2080-8.CrossRefPubMed
68.
69.
Husain S, Andrews NP, Mulcahy D, Panza JA, Quyyumi AA: Aspirin improves endothelial dysfunction in atherosclerosis. Circulation 1998, 97: 716-20.CrossRefPubMed
70.
Schneider DJ, Baumann PQ, Holmes MB, Taatjes DJ, Sobel BE: Time and dose dependent augmentation of inhibitory effects of abciximab by aspirin. Thromb Haemost 2001, 85: 309-13.PubMed
71.
Merlini PA, Bauer KA, Oltrona L, Ardissino D, Cattaneo M, Belli C, Mannucci PM, Rosenberg RD: Persistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation 1994, 90: 61-8.CrossRefPubMed
72.
Zoldhelyi P, Bichler J, Owen WG, Grill DE, Fuster V, Mruk JS, Chesebro JH: Persistent thrombin generation in humans during specific thrombin inhibition with hirudin. Circulation 1994, 90: 2671-8.CrossRefPubMed
73.
Merlini PA, Ardissino D, Bauer KA, Oltrona L, Pezzano A, Bottasso B, Rosenberg RD, Mannucci PM: Persistent thrombin generation during heparin therapy in patients with acute coronary syndromes. Arterioscler Thromb Vasc Biol 1997, 17: 1325-30.CrossRefPubMed
74.
Merlini PA, Ardissino D, Rosenberg RD, Colombi E, Agricola P, Oltrona L, Ottani F, Galvani M, Bauer KA, Bottasso B, Bertocchi F, Mannucci PM: In vivo thrombin generation and activity during and after intravenous infusion of heparin or recombinant hirudin in patients with unstable angina pectoris. Arterioscler Thromb Vasc Biol 2000, 20: 2162-6.CrossRefPubMed
75.
Ardissino D, Merlini PA, Bauer KA, Galvani M, Ottani F, Franchi F, Bertocchi F, Rosenberg RD, Mannucci PM: Coagulation activation and long-term outcome in acute coronary syndromes. Blood 2003, 102: 2731-5. 10.1182/blood-2002-03-0954CrossRefPubMed
76.
Linder R, Oldgren J, Egberg N, Grip L, Larson G, Siegbahn A, Wallentin L: The effect of a low molecular mass thrombin inhibitor, inogatran, and heparin on thrombin generation and fibrin turnover in patients with unstable coronary artery disease. Eur Heart J 1999, 20: 506-18. 10.1053/euhj.1998.1336CrossRefPubMed
77.
Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease Investigators. Lancet 1999, 354: 708-15. 10.1016/S0140-6736(99)07349-3CrossRef
78.
Neumann FJ, Kastrati A, Pogatsa-Murray G, Mehilli J, Bollwein H, Bestehorn HP, Schmitt C, Seyfarth M, Dirschinger J, Schomig A: Evaluation of prolonged antithrombotic pretreatment ["cooling-off" strategy] before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA 2003, 290: 1593-9. 10.1001/jama.290.12.1593CrossRefPubMed
79.
Esmon CT: Inflammation and thrombosis. J Thromb Haemost 2003, 1: 1343-8. 10.1046/j.1538-7836.2003.00261.xCrossRefPubMed
80.
Matthay MA: Severe sepsis-A new treatment with both anticoagulant and antiinflamatory properties. N Engl J Med 2001, 344: 759-762. 10.1056/NEJM200103083441009CrossRefPubMed
81.
Coughlin SR: Thrombin signalling and protease-activated. Nature 2000, 407: 258-264. 10.1038/35025229CrossRefPubMed
82.
Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, Kroczek RA: CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998, 391: 591-594. 10.1038/35393CrossRefPubMed
83.
84.
Wiklund O, Mattsson-Hulten L, Hurt-Camejo E, Oscarsson J: Effects of simvastatin and atorvastatin on inflammation markers in plasma. J Intern Med 2002, 25: 338-347. 10.1046/j.1365-2796.2002.00966.xCrossRef
85.
Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, Freed MI: Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 2002, 106: 679-684. 10.1161/01.CIR.0000025403.20953.23CrossRefPubMed
86.
Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W: Antidiabetic PPARγ-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2003, 23: 283-288. 10.1161/01.ATV.0000054195.35121.5ECrossRefPubMed
87.
Libby P, Ridker PM, Maseri A: Inflammation and Atherosclerosis. Circulation 2002, 105: 1135-1143. 10.1161/hc0902.104353CrossRefPubMed
88.
89.
Altman R, Luciardi HL, Muntaner J, Del Rio F, Berman SG, Lopez R, Gonzalez C: Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 [NUT-2] pilot study. Circulation 2002, 106: 191-5. 10.1161/01.CIR.0000021599.56755.A1CrossRefPubMed
90.
McKee SA, Sane DC, Deliargyris EN: Aspirin resistance in Cardiovascular disease: A review of prevalence, mechanism, and clinical significance. Thromb Haemost 2002, 88: 711-5.PubMed
Metadata
Title
The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?
Authors
Raul Altman
Héctor L Luciardi
Juan Muntaner
Ramón N Herrera
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue 1/2004
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/1477-9560-2-1

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