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A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Thrombosis Journal
Published in: Thrombosis Journal 1/2014

Open Access 01-12-2014 | Review

Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays

Authors: Jonathan Douxfils, Anne Tamigniau, Bernard Chatelain, Catherine Goffinet, Jean-Michel Dogné, François Mullier

Published in: Thrombosis Journal | Issue 1/2014

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Abstract

Traditional anticoagulant agents such as vitamin K antagonists (VKAs), unfractionated heparin (UFH), low molecular weight heparins (LMWHs) and fondaparinux have been widely used in the prevention and treatment of thromboembolic diseases. However, these agents are associated with limitations, such as the need for regular coagulation monitoring (VKAs and UFH) or a parenteral route of administration (UFH, LMWHs and fondaparinux).
Several non-VKA oral anticoagulants (NOACs) are now widely used in the prevention and treatment of thromboembolic diseases and in stroke prevention in non-valvular atrial fibrillation. Unlike VKAs, NOACs exhibit predictable pharmacokinetics and pharmacodynamics. They are therefore usually given at fixed doses without routine coagulation monitoring. However, in certain patient populations or special clinical circumstances, measurement of drug exposure may be useful, such as in suspected overdose, in patients experiencing a hemorrhagic or thromboembolic event during the treatment’s period, in those with acute renal failure, in patients who require urgent surgery or in case of an invasive procedure. This article aims at providing guidance on laboratory testing of classic anticoagulants and NOACs.
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Metadata
Title
Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays
Authors
Jonathan Douxfils
Anne Tamigniau
Bernard Chatelain
Catherine Goffinet
Jean-Michel Dogné
François Mullier
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue 1/2014
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/1477-9560-12-24

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