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Reproductive Biology and Endocrinology

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Open Access 01-12-2014 | Short communication

Variant-beta luteinizing hormone is not associated with poor ovarian response to controlled ovarian hyperstimulation

Authors: Hans I Hanevik, Hilde T Hilmarsen, Camilla F Skjelbred, Tom Tanbo, Jarl A Kahn

Published in: Reproductive Biology and Endocrinology | Issue 1/2014

Abstract

Background

The most common genetic variant of luteinizing hormone (LH), variant-betaLH, has a different bioactivity than the wildtype. Carrying the variant allele was associated with an increased consumption of exogenous gonadotropin to achieve optimal ovarian response for in vitro fertilization procedures (IVF). The aim of this study was to examine if variant-betaLH was also more common in patients with a poor ovarian response to exogenous gonadotropin which negatively influenced treatment outcome.

Findings

36 patients with poor ovarian response to ovarian stimulation for IVF and 98 controls with a normal response were genotyped for variant-betaLH using DNA sequencing. The carrier frequency in the control group was 17%. No association was found between poor ovarian response and variant-betaLH.

Conclusions

Testing patients for variant-betaLH prior to IVF is unlikely to predict poor ovarian response.

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Title: Variant-beta luteinizing hormone is not associated with poor ovarian response to controlled ovarian hyperstimulation
Authors: Hans I Hanevik
Hilde T Hilmarsen
Camilla F Skjelbred
Tom Tanbo
Jarl A Kahn
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2014
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-12-20

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Variant-beta luteinizing hormone is not associated with poor ovarian response to controlled ovarian hyperstimulation

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Findings

Conclusions

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