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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2012

Open Access 01-12-2012 | Research

A questionnaire-based survey to assess patient satisfaction, ease-of-learning, ease-of-use, injection site pain and overall patient satisfaction of the follitropin-alpha (Gonal-f) filled-by-mass (FbM) prefilled pen compared with other systems of gonadotrophin administration

Authors: Takafumi Utsunomiya, Atsushi Tanaka, Kenichi Tatsumi, Diego Ezcurra

Published in: Reproductive Biology and Endocrinology | Issue 1/2012

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Abstract

Background

Gonadotrophins are used routinely for follicular stimulation during ovarian induction and assisted reproduction techniques. Developments in recombinant follicle-stimulating hormone preparations and their injection devices have improved patient quality of life by enabling patients to self-administer treatment at home. The objective of this study was to investigate patient experiences of learning to use and overall satisfaction with the follitropin-alpha (Gonal-f) filled-by-mass (FbM) prefilled pen.

Methods

This questionnaire-based survey study was conducted in 23 fertility centres in Japan over a period of 14 months. Patients who were receiving fertility treatment with the follitropin-alpha (FbM) prefilled pen were asked to complete a questionnaire to assess their satisfaction, ease of learning and use, and injection site pain following treatment.

Results

A total of 663 women participated in the study. The majority of patients found the instructions for administering follitropin-alpha with the prefilled pen easy to understand (83.0%; n = 546/658) and patients found that a hands-on demonstration by a nurse or doctor was the most useful tool for learning to use the follitropin-alpha (FbM) prefilled pen (80.0%; n = 497/621). Forty-eight percent (n = 318) of patients in the study had previous experience with different types of fertility medications and the majority of these patients found the follitropin-alpha (FbM) prefilled pen easier to use (75.1%; n = 232/309) and less painful (89.0%; n = 347/390) than their previous medication. The majority (80.2%; n = 521/650) of patients reported overall satisfaction with the follitropin-alpha (FbM) prefilled pen.

Conclusions

The follitropin-alpha (FbM) prefilled pen is an easy-to-use injection device according to this questionnaire-based survey. Patients who had experience of different types of fertility medication preferred the follitropin-alpha (FbM) prefilled pen to other injection devices.
Appendix
Available only for authorised users
Literature
1.
Oehninger S: Ovulation induction in IVF. Minerva Ginecol. 2011, 63: 137-156.PubMed
2.
Oehninger S, Hodgen GD: Induction of ovulation for assisted reproduction programmes. Baillieres Clin Obstet Gynaecol. 1990, 4: 541-573. 10.1016/S0950-3552(05)80310-4.CrossRefPubMed
3.
Mahato RI, Narang AS, Thoma L, Miller DD: Emerging trends in oral delivery of peptide and protein drugs. Crit Rev Ther Drug Carrier Syst. 2003, 20: 153-214. 10.1615/CritRevTherDrugCarrierSyst.v20.i23.30.CrossRefPubMed
4.
Pang SC: A pen injection device for self-administration of recombinant follicle-stimulating hormone for fertility treatments. Expert Rev Med Devices. 2005, 2: 27-32. 10.1586/17434440.2.1.27.CrossRefPubMed
5.
Somkuti SG, Schertz JC, Moore M, Ferrande L, Kelly E: Patient experience with follitropin alfa prefilled pen versus previously used injectable gonadotropins for ovulation induction in oligoanovulatory women. Curr Med Res Opin. 2006, 22: 1981-1996. 10.1185/030079906X132604.CrossRefPubMed
6.
Platteau P, Laurent E, Albano C, Osmanagaoglu K, Vernaeve V, Tournaye H, Camus M, Van Steirteghem A, Devroey P: An open, randomized single-centre study to compare the efficacy and convenience of follitropin beta administered by a pen device with follitropin alpha administered by a conventional syringe in women undergoing ovarian stimulation for IVF/ICSI. Hum Reprod. 2003, 18: 1200-1204. 10.1093/humrep/deg234.CrossRefPubMed
7.
Sedbon E, Wainer R, Perves C: Quality of life of patients undergoing ovarian stimulation with injectable drugs in relation to medical practice in France. Reprod Biomed Online. 2006, 12: 298-303. 10.1016/S1472-6483(10)61001-2.CrossRefPubMed
8.
Bassett RM, Driebergen R: Continued improvements in the quality and consistency of follitropin alfa, recombinant human FSH. Reprod Biomed Online. 2005, 10: 169-177. 10.1016/S1472-6483(10)60937-6.CrossRefPubMed
9.
Craenmehr E, Bontje PM, Hoomans E, Voortman G, Mannaerts BM: Follitropin-beta administered by pen device has superior local tolerance compared with follitropin-alpha administered by conventional syringe. Reprod Biomed Online. 2001, 3: 185-189. 10.1016/S1472-6483(10)62033-0.CrossRefPubMed
10.
Markle RL, King PJ, Martin DB: Characteristics of successful human chorionic gonadotrophin (hCG) administration in assisted reproduction [abstract]. Fertil Steril. 2002, 78 (Suppl 1): S71-S72.CrossRef
11.
Pang S, Kaplan B, Karande V, Westphal LM, Scott R, Givens C, Sacks P: Administration of recombinant human FSH (solution in cartridge) with a pen device in women undergoing ovarian stimulation. Reprod Biomed Online. 2003, 7: 319-326. 10.1016/S1472-6483(10)61871-8.CrossRefPubMed
12.
Alviggi C, Revelli A, Anserini P, Ranieri A, Fedele L, Strina I, Massobrio M, Ragni N, De PG: A prospective, randomised, controlled clinical study on the assessment of tolerability and of clinical efficacy of Merional (hMG-IBSA) administered subcutaneously versus Merional administered intramuscularly in women undergoing multifollicular ovarian stimulation in an ART programme (IVF). Reprod Biol Endocrinol. 2007, 5: 45-10.1186/1477-7827-5-45.PubMedCentralCrossRefPubMed
13.
Weckler : Post marketing surveillance analysis of the routine use of follitrophin alpha in a prefilled ready to use injection pen in ART [abstract]. Fertil Steril. 2006, 86: S411-
14.
Porter R, Kissel C, Saunders H, Keck C: Patient and nurse evaluation of recombinant human follicle-stimulating hormone administration methods: comparison of two follitropin injection pens. Curr Med Res Opin. 2008, 24: 727-735. 10.1185/030079908X273291.CrossRefPubMed
15.
Weiss N: Gonadotrophin products: empowering patients to choose the product that meets their needs. Reprod Biomed Online. 2007, 15: 31-37. 10.1016/S1472-6483(10)60688-8.CrossRefPubMed
16.
Dumas H, Panayiotopoulos P, Parker D, Pongpairochana V: Understanding and meeting the needs of those using growth hormone injection devices. BMC Endocr Disord. 2006, 6: 5-10.1186/1472-6823-6-5.PubMedCentralCrossRefPubMed
17.
Bohannon NJ: Insulin delivery using pen devices. Simple-to-use tools may help young and old alike. Postgrad Med. 1999, 106: 57-68.CrossRefPubMed
18.
Brunton S: Initiating insulin therapy in type 2 diabetes: benefits of insulin analogs and insulin pens. Diabetes Technol Ther. 2008, 10: 247-256. 10.1089/dia.2008.0287.CrossRefPubMed
19.
Hanestad BR, Albrektsen G: Quality of life, perceived difficulties in adherence to a diabetes regimen, and blood glucose control. Diabet Med. 1991, 8: 759-764. 10.1111/j.1464-5491.1991.tb01696.x.CrossRefPubMed
20.
Pfutzner A, Asakura T, Sommavilla B, Lee W: Insulin delivery with FlexPen: dose accuracy, patient preference and adherence. Expert Opin Drug Deliv. 2008, 5: 915-925. 10.1517/17425247.5.8.915.CrossRefPubMed
21.
Kadiri A, Chraibi A, Marouan F, Ababou MR, el Guermai N, Wadjinny A, Kerfati A, Douiri M, Bensouda JD, Belkhadir J, et al: Comparison of NovoPen 3 and syringes/vials in the acceptance of insulin therapy in NIDDM patients with secondary failure to oral hypoglycaemic agents. Diabetes Res Clin Pract. 1998, 41: 15-23. 10.1016/S0168-8227(98)00055-2.CrossRefPubMed
22.
Sucic M, Galic E, Cabrijan T, Ivandic A, Petrusic A, Wyatt J, Mincheva N, Milicevic Z, Malone J: Patient acceptance and reliability of new Humulin/Humalog 3.0 ml prefilled insulin pen in ten Croatian diabetes centres. Med Sci Monit. 2002, 8: I21-I26.
23.
Heisler M, Bouknight RR, Hayward RA, Smith DM, Kerr EA: The relative importance of physician communication, participatory decision making, and patient understanding in diabetes self-management. J Gen Intern Med. 2002, 17: 243-252. 10.1046/j.1525-1497.2002.10905.x.PubMedCentralCrossRefPubMed
24.
Schattner A, Bronstein A, Jellin N: Information and shared decision-making are top patients’ priorities. BMC Health Serv Res. 2006, 6: 21-10.1186/1472-6963-6-21.PubMedCentralCrossRefPubMed
25.
Hovatta O, McVeigh E, Lass A, Homburg R: A large Northern European observational study of follitropin alpha filled-by-mass pre-filled pen. Reprod Biomed Online. 2009, 18: 502-508. 10.1016/S1472-6483(10)60126-5.CrossRefPubMed
26.
DiMatteo MR: The physician-patient relationship: effects on the quality of health care. Clin Obstet Gynecol. 1994, 37: 149-161. 10.1097/00003081-199403000-00019.CrossRefPubMed
27.
Chen LN, Quan S, Li H, Yang XP, Chen SM, Zhang XY, Lin L, Xing FQ, Chen SL, Wan ZJ, et al: Clinical application of prefilled pen and conventional syringe during controlled ovarian stimulation for in vitro fertilization. Nan Fang Yi Ke Da Xue Xue Bao. 2009, 29: 100-104.PubMed
28.
Christianson MS, Barker MA, Schouweiler C, Lindheim SR: A retrospective comparison of clinical outcomes and satisfaction using reconstituted recombinant gonadotropins (rFSH) or cartridge rFSH with a pen device in donor oocyte cycles. Curr Med Res Opin. 2007, 23: 865-870. 10.1185/030079907X178784.CrossRefPubMed
29.
Rama Raju GA, Suryanarayana K, Jaya PG, Murali KK: Comparison of follitropin-beta administered by a pen device with conventional syringe in an ART programme - a retrospective study. J Clin Pharm Ther. 2008, 33: 401-407. 10.1111/j.1365-2710.2008.00931.x.CrossRefPubMed
Metadata
Title
A questionnaire-based survey to assess patient satisfaction, ease-of-learning, ease-of-use, injection site pain and overall patient satisfaction of the follitropin-alpha (Gonal-f) filled-by-mass (FbM) prefilled pen compared with other systems of gonadotrophin administration
Authors
Takafumi Utsunomiya
Atsushi Tanaka
Kenichi Tatsumi
Diego Ezcurra
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2012
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-10-93

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