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Open Access 01-12-2011 | Case report

A case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy after primary treatment of triple-negative breast cancer

Authors: Hideo Shigematsu, Takayuki Kadoya, Yoshie Kobayashi, Keiko Kajitani, Tatsunari Sasada, Akiko Emi, Norio Masumoto, Rumi Haruta, Tsuyoshi Kataoka, Miyo Oda, Kouji Arihiro, Morihito Okada

Published in: World Journal of Surgical Oncology | Issue 1/2011

Abstract

We report a case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy 6 years after primary treatment of triple-negative breast cancer. The primary tumor was negative for HER-2 as determined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (1+, and ratio, 1.1), but examination of the recurrent lymph node metastasis showed positivity for HER-2 by FISH (ratio, 5.2). No lesions were detected in either her left breast or in other organs, and the patient was diagnosed as having HER-2-positive recurrent disease. Combination chemotherapy using weekly paclitaxel and trastuzumab was initiated, and a clinically complete response was achieved. This report suggests the benefit of routine evaluation of HER-2 status in recurrent breast cancer with the introduction of HER-2-targeting agents.

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Title: A case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy after primary treatment of triple-negative breast cancer
Authors: Hideo Shigematsu
Takayuki Kadoya
Yoshie Kobayashi
Keiko Kajitani
Tatsunari Sasada
Akiko Emi
Norio Masumoto
Rumi Haruta
Tsuyoshi Kataoka
Miyo Oda
Kouji Arihiro
Morihito Okada
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2011
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-9-146

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy after primary treatment of triple-negative breast cancer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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