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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2011

Open Access 01-12-2011 | Research

Partial nephrectomy using porcine small intestinal submucosa

Authors: Thomas J Schnoeller, Robert de Petriconi, Robert Hefty, Florian Jentzmik, Sandra Waalkes, Friedemann Zengerling, Mark Schrader, Andres J Schrader

Published in: World Journal of Surgical Oncology | Issue 1/2011

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Abstract

Background

Whenever technically feasible and oncologically justified, nephron-sparing surgery is the current standard of care for localized renal cell carcinomas (RCC). The main complications of partial nephrectomy, especially for large and centrally located tumors, are urinary leakage and parenchymal bleeding. We prospectively evaluated the pros and cons of using porcine small intestinal submucosa (SIS, Surgisis®) to close the renal defect after nephron-sparing surgery.

Methods

We used Surgisis® (Cook medical, Bloomington, IN, USA) to secure and compress the capsular defect after tumor resection in 123 patients submitted to 129 partial nephrectomies between August 2003 and February 2011.

Results

The median tumor size was 3.7 cm (range 1.1-13.0 cm). Procedures were performed with cold ischemia in 24 cases (18.2%), with warm ischemia in 46 (35.6%), and without ischemia in 59 cases (44.8%). In the total group of patients, 4 (3.1%) developed urinary fistula, and only 2 (1.6%) required postoperative transfusions due to hemorrhage after the application of the small intestinal submucosa membrane.

Conclusion

Small intestinal submucosa is an easy-to-use biomaterial for preventing complications such as postoperative bleeding and urinary fistula in nephron-sparing surgery, especially in cases where tumor excision causes significant renal capsular and/or renal pelvic defects.
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Metadata
Title
Partial nephrectomy using porcine small intestinal submucosa
Authors
Thomas J Schnoeller
Robert de Petriconi
Robert Hefty
Florian Jentzmik
Sandra Waalkes
Friedemann Zengerling
Mark Schrader
Andres J Schrader
Publication date
01-12-2011
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2011
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-9-126

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